1 results match your criteria: "Nanjing Medical University School of Pharmacy (H.-G.X.)[Affiliation]"
Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood.
Drug Metab Dispos
February 2018
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University (J.-Z.J., T.T., B.-B.H., T.-T.G., Q.-Y.M., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University (H.-G.X.); and Department of Pharmacology and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy (H.-G.X.), Nanjing, People's Republic of China
Clopidogrel acyl glucuronide (CLP-G) is a major phase II metabolite of clopidogrel generated in the liver for further excretion into urine; however, it is unclear whether CLP-G transports from hepatocytes into blood. Because multidrug resistance-associated protein 3 (MRP3) is predominantly expressed in the sinusoidal side of hepatocytes and preferentially transports glucuronide conjugates of drug metabolites from hepatocytes into bloodstream, we hypothesized that MRP3 could be such an efflux transporter for CLP-G. In this study, we compared the liver-to-plasma ratios of clopidogrel and its metabolites (including CLP-G) between (ATP-binding cassette, subfamily C, member 3) knockout (KO) and wild-type (WT) mice.
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