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Effects of ischemic preconditioning on the systemic and renal hemodynamic changes in renal ischemia reperfusion injury.

Int J Clin Exp Pathol

March 2016

Department of Urology, Nanjing First Hospital, Nanjing Medical University 68 Changle Road, Nanjing 210006, China ; Center for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University 68 Changle Road, Nanjing 210006, China.

Article Synopsis
  • Ischemic preconditioning (IPC) helps protect the kidneys from damage caused by ischemia-reperfusion injury (IRI), although the exact mechanisms are still not fully understood.* -
  • In a study with male Sprague-Dawley rats, different treatment groups were established to assess how IPC affects renal function, blood flow, and key nitric oxide synthase levels following vascular clamping.* -
  • Results showed that IPC significantly improved kidney function and blood flow, linked to increased levels of endothelial and inducible nitric oxide synthase (eNOS/iNOS) and nitric oxide (NO), though these benefits were negated when nitric oxide production was inhibited.*
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