Bioadhesive First-Aid Patch with Rapid Hemostasis and High Toughness Designed for Sutureless Sealing of Acute Bleeding Wounds.

The global military and civilian sectors express widespread concern over the significant hemorrhage associated with various acute wounds. Such bleedings lead to numerous casualties in military confrontations, traffic accidents, and surgical injuries. Consequently, the rapid control of the bleedings, particularly for extensive and pressurized wounds, is crucial in first-aid situations.

Rapidly molded sodium alginate/soy protein adhesive hydrogel with 808-nm laser inhibition of infected wounds.

Infected wounds produce pus and heal slowly. To address this issue, we developed a rapid-setting SP/SA@BP-C hydrogel by combining sodium alginate (SA) and soy protein (SP) with black phosphorus (BP) grafted with clarithromycin (Cla) and incorporating Ca for chelation. This hydrogel dressing exhibits excellent photothermal (PT) and photodynamic (PD) bacteriostatic effects without biotoxicity, making it suitable for treating infected wounds.

Development of sensitive biomass xylan-based carbon dots fluorescence sensor for quantification detection Cu in real water and soil.

Copper ions (Cu) pose significant risks to both human health and the environment as they tend to accumulate in soil and water. To address this issue, an innovative method using biomass-derived fluorescent carbon dots (D-CDs) synthesized via a hydrothermal process, with xylan serving as the carbon source was developed. D-CDs solution exhibited remarkable sensitivity and selectivity as a fluorescence sensor for Cu, boasting a low detection threshold of 0.

Biomimetic triggered release from hydroxyethyl cellulose @ Prussian blue microparticles for tri-modality biofilm removal.

Human health is under growing threat from the increasing incidence of bacterial infections. Through their antimicrobial mechanisms, bacteria use appropriate strategies to overcome the antimicrobial effects of antibiotics. The enhanced effects of synergistic strategies on drug-resistant bacteria and biofilms have led to increasing interest in these approaches in recent years.

Effects of multi-walled carbon nanotubes and halloysite nanotubes on plasma lipid profiles and autophagic lipolysis pathways in mouse aortas and hearts.

Multi-walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HNTs) are widely used tubular-structured nanomaterials (NMs), but their cardiovascular effects are not clear. This study compared the effects of MWCNTs and HNTs on lipid profiles in mouse plasma and gene expression profiles in aortas and hearts. Mice were intravenously injected with 50 μg NMs, once a day, for 5 days.

Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae.

Graphdiyne (GDY) is a new member of family of carbon-based 2D nanomaterials (NMs), but the environmental toxicity is less investigated compared with other 2D NMs, such as graphene oxide (GO). In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity.

Synergy of Active Sites and Charge Transfer in Branched WO/WO Heterostructures for Enhanced NO Sensing.

Achieving reliable detection of trace levels of NO gas is essential for environmental monitoring and protection of human health protection. Herein, a thin-film gas sensor based on branched WO/WO heterostructures was fabricated. The optimized WO/WO sensor exhibited outstanding NO sensing properties with an ultrahigh response value (1038) and low detection limit (10 ppb) at 50 °C.

Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine.

To evaluate the oral toxicity of nanoparticles (NPs), it is necessary to consider the interactions between NPs and nutrient molecules. Recently, we reported that epigallocatechin gallate (EGCG), a healthy component in green tea, alleviated the toxicity of ZnO NPs to 3D Caco-2 spheroids in vitro. The present study investigated the combined effects of EGCG and ZnO NPs to mice in vivo.

Xylan derived fluorescence carbon dots composite with cotton cellulose paper as 'turn-off' fluorescence platform for sensitive and selective detection Cu in real samples.

The pollution of heavy metals such as Cu is still serious and the discharge of sewage of Cu will cause damage to soil environment and human health. Herein, a biomass-based solid-state fluorescence detection platform (CPU-CDs) was developed as fluorescent sensor for detection Cu via fluorescence and colorimetric dual-model methods in real time. CPU-CDs was composed of xylan-derived CDs (U-CDs) and cotton cellulose paper, which exhibiting good reusability, non-toxicity, excellent fluorescence characteristics and high biocompatibility.

Biomass-based indole derived fluorescence sensor composited with cellulose paper: Detection of picric acid in food and environment samples.

Picric acid (PA) is highly water-soluble, the fact makes it stand out as the most hazardous environment pollutant. Therefore, accurate determination of PA is of great significance for human health and environmental protection. Herein, a novel indole-based fluorescent sensor (H1) with good water solubility and fluorescence stability was reported.

Xylan derived carbon dots composite with PCL/PLA for construction biomass nanofiber membrane used as fluorescence sensor for detection Cu in real samples.

Water and soil pollution caused by Cu is not conducive to sustainable development of environment and could cause damage to environment and even human body. Currently, fluorescent sensor solutions analysis method has been used for Cu detection, but they also suffer from drawbacks including easy leakage, difficult storage, and inaccurate. Herein, a green solid-state biomass fluorescence platform (NBU-CDs) consisting of xylan-derived carbon dots (U-CDs) and polylactic acid/polycaprolactone (PLA/PCL) was designed by using in situ electrospinning technology.

Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.

The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.) is important for the development of slash pine resources. The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.

Photothermal Nanomaterial-Mediated Photoporation.

Delivering biological effector molecules in cultured cells is of fundamental importance to any study or application in which the modulation of gene expression is required. Examples range from generating engineered cell lines for studying gene function to the engineering of cells for cell-based therapies such as CAR-T cells and gene-corrected stem cells for regenerative medicine. It remains a great challenge, however, to deliver biological effector molecules across the cell membrane with minimal adverse effects on cell viability and functionality.

Potential new material for optical fiber: Preparation and characterization of transparent fiber based on natural cellulosic fiber and epoxy.

In order to reduce the dependence on fossil energy products, natural fiber/polymer hybrid composites have been increasingly researched. The high price of the quartz optical fibers and glass optical fibers has greatly inspired researchers to engage in the research on polymer optical fibers. Herein, transparent fibers based on plant fibers were innovatively prepared for the first time by delignification and impregnating epoxy diluted with acetone.

RuO-Incorporated CoO Nanoneedles Grown on Carbon Cloth as Binder-Free Integrated Cathodes for Tuning Favorable LiO Formation.

Developing ideal Li-O batteries (LOBs) requires the discharge product to have a large quantity, have large contact area with the cathode, and not passivate the porous surface after discharge, which put forward high requirement for the design of cathodes. Herein, combining the rational structural design and high activity catalyst selection, minor amounts of RuO-incorporated CoO nanoneedles grown on carbon cloth are successfully synthesized as binder-free integrated cathodes for LOBs. With this unique design, plenty of electron-ion-oxygen tri-phase reaction interface is created, the side reaction from carbon is isolated, and oxygen reduction reaction/oxygen evolution reaction (OER) kinetics are significantly facilitated.

Biomaterials based on hyaluronic acid, collagen and peptides for three-dimensional cell culture and their application in stem cell differentiation.

In recent decades, three-dimensional (3D) cell culture technologies have been developed rapidly in the field of tissue engineering and regeneration, and have shown unique advantages and great prospects in the differentiation of stem cells. Herein, the article reviews the progress and advantages of 3D cell culture technologies in the field of stem cell differentiation. Firstly, 3D cell culture technologies are divided into two main categories: scaffoldless and scaffolds.

Application of ,-Dimethylethanolamine as a One-Carbon Synthon for the Synthesis of Pyrrolo[1,2-]quinoxalines, Quinazolin-4-ones, and Benzo[4,5]imidazoquinazolines [5 + 1] Annulation.

The synthesis of -heterocycles composes a significant part of synthetic chemistry. In this report, a Cu(II)-catalyzed green and efficient synthesis of pyrrolo[1,2-]quinoxaline, quinazolin-4-one, and benzo[4,5]imidazoquinazoline derivatives was developed, employing -dimethylethanolamine (DMEA) as a C1 synthon. Green oxidant O is critical in these transformations, facilitating the formation of a key intermediate─a reactive iminium ion.

Facile construction of ,-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction.

A green and facile synthesis of previously unreported ,-disulfonated 5-amino pyrazoles was established through an iodine-catalyzed cascade reaction of easily accessible sulfonyl hydrazides, β-ketonitriles, and sodium sulfinates. Diverse ,-disulfonated 5-amino pyrazoles could be obtained in 38-88% yields. This methodology features green and mild conditions, broad substrate scope, and effortless work-up.

Potential application of natural bioactive compounds as skin-whitening agents: A review.

Background: Melanin is a skin pigment that gives color to the skin, hair, and eyes. The accumulation or over production of melanin can lead to aesthetic problems as well as serious diseases associated with hyperpigmentation. Skin lightening is described as the procedure of using natural or synthetic products to lighten the skin tone or provide an even skin complexion by reducing the amount of melanin in the skin; therefore, skin lightening products help people to treat their skin problems.

Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation.

Inspired by the structure of eukaryotic cells, multicompartmental microcapsules have gained increasing attention. However, challenges remain in the fabrication of "all-aqueous" (., oil-free) microcapsules composed of accurately adjustable hierarchical compartments.

Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism suppressing TLR3 in vascular smooth muscle cells.

Vascular smooth muscle cells (VSMCs), the main cells constructing blood vessels, are important in the regulation of the pathophysiology of vascular systems; however, relatively few studies have investigated the influence of nanomaterials (NMs) on VSMCs. In this study, we found that the interaction between graphene oxide and human VSMCs led to the cytotoxicity and morphological changes of cells. Because transcriptomic data suggested that graphene oxide decreased anti-viral signaling pathways decreasing Toll-like receptor 3 (TLR3), we further verified that graphene oxide decreased interferon induced protein with tetratricopeptide repeats 1 (IFIT1) and the radical -adenosyl methionine domain containing 2 (RSAD2), and TLR3-downstream genes involved in anti-viral responses.