3 results match your criteria: "Nanjing Clinical School of Southern Medical University (Guangzhou)[Affiliation]"
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling.
Biol Chem
November 2019
Department of Respiratory and Critical Medicine, Jinling Hospital, Nanjing Clinical School of Southern Medical University (Guangzhou), 305 Zhongshan Road, Nanjing 210002, P.R. China.
Geranylgeranyl diphosphate synthase (GGPPS) is an enzyme that catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP). GGPPS is implicated in many disorders, but its role in idiopathic pulmonary fibrosis (IPF) remains unclear. This study aimed to investigate the role of GGPPS in IPF.
View Article and Find Full Text PDFTopotecan alleviates ventilator-induced lung injury via NF-κB pathway inhibition.
Cytokine
October 2018
Department of Respiratory and Critical Medicine, Jinling Hospital, Nanjing Clinical School of Southern Medical University (Guangzhou), Nanjing 210002, China. Electronic address:
Objective: We investigated the effect of topotecan on injury and inflammation in a model of ventilator-inducedlunginjury (VILI).
Methods: Acute lung injury (ALI) was induced in mice by high-tidal volume ventilation, and the mice were then treated with topotecan or PBS. Lung tissue and bronchoalveolar lavage fluid were collected to assess pulmonary vascular leaks, inflammation, and cell apoptosis.
Plasma long noncoding RNA IL-7R as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome.
Clin Respir J
April 2018
Department of Respiratory and Critical Medicine, Jinling Hospital, Nanjing Clinical School of Southern Medical University (Guangzhou), Nanjing 200000, China.
Article Synopsis
- Lnc-IL7R is a long non-coding RNA that plays a crucial role in regulating inflammation and has been investigated for its potential as a biomarker in acute respiratory distress syndrome (ARDS).
- The study involved comparing plasma levels of lnc-IL7R in 85 ARDS patients and 49 healthy controls, revealing that lnc-IL7R levels were significantly lower in ARDS patients, particularly in severe cases, and correlated with disease severity.
- The findings suggest that lnc-IL7R could serve as a reliable biomarker for diagnosing ARDS and predicting the 28-day mortality rate among affected individuals.