Comparative efficacy analysis of laparoscopic-assisted transanal total mesorectal excision laparoscopic transanal mesorectal excision for low-lying rectal cancer.

Background: With the continuous development of laparoscopic techniques in recent years, laparoscopic total mesorectal excision (LapTME) and laparoscopic-assisted transanal total mesorectal excision (TaTME) have gradually become important surgical techniques for treating low-lying rectal cancer (LRC). However, there is still controversy over the efficacy and safety of these two surgical modalities in LRC treatment.

Aim: To compare the efficacy of LapTME TaTME in patients with LRC.

The SARS-CoV-2 rS1-E-PLGA nanovaccine and evaluation of its immune effect in BALB/c mice.

Objective: Vaccination is an important method for preventing COVID-19 infection. However, certain vaccines do not meet the current needs. To improve the vaccine effect, discard ineffective antigens, and focus on high-quality antigenic clusters, S1-E bivalent antigens were designed.

Nasal Nanovaccines for SARS-CoV-2 to Address COVID-19.

COVID-19 is still prevalent around the globe. Although some SARS-CoV-2 vaccines have been distributed to the population, the shortcomings of vaccines and the continuous emergence of SARS-CoV-2 mutant virus strains are a cause for concern. Thus, it is vital to continue to improve vaccines and vaccine delivery methods.

Progress in the Understanding of the Mechanism of Tamoxifen Resistance in Breast Cancer.

Tamoxifen is a drug commonly used in the treatment of breast cancer, especially for postmenopausal patients. However, its efficacy is limited by the development of drug resistance. Downregulation of estrogen receptor alpha (ERα) is an important mechanism of tamoxifen resistance.

[The impact of asthma on nasal function in patient with allergic rhinitis].

To observe the impact of lower allergic respiratory inflammation on nasal function in patient with allergic rhinitis. Patients were divided into three group: allergic rhinitis group, allergic rhinitis with asthma group and control group; the nasal mucociliary transporting rate was evaluated by saccharin test; The pH of nasal mucosa extraction was evaluated by pH test paper; the nasal resistance was evaluated by nasal resistance instrument; the content of eosinophil cationic protein of nasal lavage fluid was evaluated by immunofluorescence. The nasal mucociliary transporting rate was 13.