Modular Construction of Prussian Blue Analog and TiO Dual-Compartment Janus Nanoreactor for Efficient Photocatalytic Water Splitting.

Janus structures that include different functional compartments have attracted significant attention due to their specific properties in a diverse range of applications. However, it remains challenge to develop an effective strategy for achieving strong interfacial interaction. Herein, a Janus nanoreactor consisting of TiO 2D nanocrystals integrated with Prussian blue analog (PBA) single crystals is proposed and synthesized by mimicking the planting process.

SKLB023 protects mice against acute liver injury by inhibiting proinflammatory cytokine production in both T cells and macrophages.

Acute liver failure is a severe clinical syndrome accompanied with excessive inflammatory response. Our previous study demonstrated that SKLB023, a novel thiazolidinedione derivative, showed potent anti-inflammatory activity in rheumatoid arthritis. The purpose of the present study is to evaluate the protective effect of SKLB023 on lipopolysaccharide (LPS)/D-GalN-induced liver failure and to explore the underlying molecular mechanisms.