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Article Synopsis
  • The study aimed to assess how age and baseline characteristics influenced the effects of pravastatin treatment on cardiovascular disease (CVD) risk among Japanese patients with mild to moderate hyperlipidemia.
  • Researchers analyzed 7,832 participants divided into six age groups and found that older men had higher rates of diabetes and hypertension, while younger men had more smoking and obesity.
  • Pravastatin treatment showed a 30-40% reduction in CVD risk for all age groups, with older women experiencing a particularly significant decrease in risk compared to younger women.
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Background: The Japan Lipid Intervention Trial was a nationwide cohort study of 52,421 hypercholesterolemic patients treated with open-labeled simvastatin for 6 years under standard clinical practices. Cerebrovascular disease (CVD) is one of the leading causes of death in Japan, but the effect of hypercholesterolemia on CVD has not been well established in Japanese patients. This study aimed to determine the relationship between the risk of CVD and serum lipid concentrations during treatment in Japan.

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