1 results match your criteria: "Nagoya University of Art and Sciences[Affiliation]"
Involvement of glial activation in trigeminal ganglion in a rat model of lower gingival cancer pain.
Nagoya J Med Sci
August 2014
School of Human Care, Nagoya University of Art and Sciences, Nisshin, Japan.
Article Synopsis
- The study investigated the role of glial cells in oral cancer pain using a rat model of squamous cell carcinoma (SCC-158) inoculated into the lower gingiva.
- The inoculation led to significant mechanical allodynia in specific skin areas, with increased TRPV1 and TRPV2 expression in trigeminal ganglia neurons, linked to pain sensation, while morphine was effective in reducing allodynia symptoms.
- Interestingly, while satellite glial cell activity increased over time, microglia and astrocytes in the spinal nucleus caudalis were not activated, suggesting that targeting TRPV1, TRPV2, and satellite cells could offer new therapeutic approaches for managing oral cancer pain.