5 results match your criteria: "Nagoya City University East Medical Centre[Affiliation]"
Evaluation of ARID1A as a Potential Biomarker for Predicting Response to Immune Checkpoint Inhibitors in Patients with Endometrial Cancer.
Cancers (Basel)
May 2024
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan.
Background: AT-rich interaction domain 1A (ARID1A) has been proposed as a new biomarker for predicting response to immune checkpoint inhibitors (ICIs). The predictive value of ARID1A for predicting ICI effectiveness has not been reported for endometrial cancer. Therefore, we investigated whether ARID1A negativity predicts ICI effectiveness for endometrial cancer treatment.
View Article and Find Full Text PDFCharacterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.
J Pharmacol Sci
October 2022
Department of Infectious Diseases, Nagoya City University East Medical Centre, Nagoya, Japan.
Article Synopsis
- * A study analyzed the levels of kynurenine, tryptophan, and serotonin in the serum of COVID-19 patients using advanced techniques.
- * Findings indicate that lower serotonin levels in patients correlate with more severe cases of COVID-19, suggesting that serotonin could serve as a useful biomarker for assessing disease severity and patient outlook.
Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression.
J Pharmacol Sci
September 2022
Department of Infectious Diseases, Nagoya City University East Medical Centre, Nagoya, Japan.
The prognosis of patients with severe cases of COVID-19 is poor; thus, biomarkers for earlier prediction of COVID-19 progression are vital. We measured levels of five lung injury-related biomarkers, SP-D, KL-6, presepsin, kallistatin and stratifin, in serum samples collected serially during hospitalization from 31 patients with mild/moderate or severe/critical COVID-19 pneumonia, and their predictive performances were compared. Like the previously reported presepsin, a new biomarker candidate, stratifin, was significantly elevated with the onset of severe or critical symptoms in COVID-19 patients and decreased with symptom improvement.
View Article and Find Full Text PDFAcoustic neuromas associated with sudden sensorineural hearing loss.
Acta Otolaryngol
May 2022
Department of Otolaryngology-Head and Neck Surgery, Nagoya City University East Medical Centre, Nagoya City, Japan.
Background: Several studies have reported sudden sensorineural hearing loss (SHL) as an initial symptom of acoustic neuromas (ANs).
Aims/objectives: We aimed to retrospectively evaluate the incidence of SHL and the associated rates of post-treatment improvement in patients diagnosed with ANs.
Materials And Methods: We analysed the clinical data of 686 patients with ANs and examined tumour size, correlation with hearing loss, number of episodes of SHL, extent of auditory recovery, and associated audiogram patterns.
High variability in results and methodological quality among overlapping systematic reviews on the same topics in surgery: a meta-epidemiological study.
Br J Surg
December 2021
Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan.
Background: Redundant publication of systematic reviews and meta-analyses (SRs/MAs) on the same topic presents an increasing burden for clinicians. The aim of this study was to describe variabilities in effect size and methodological quality of overlapping surgery-related SRs/MAs and to investigate factors associated with their postpublication citations.
Methods: PubMed/MEDLINE was searched to identify SRs/MAs of RCTs on thoracoabdominal surgeries published in 2015.