574 results match your criteria: "Nagayama Hospital[Affiliation]"

Article Synopsis
  • A study analyzed data from over 30,000 Japanese patients aged 75 and older with non-valvular atrial fibrillation (AF) to understand the incidence and risk factors for coronary events (CE), including myocardial infarction (MI) and cardiac interventions.
  • The 2-year follow-up found a CE incidence rate of 0.48 per 100 patient-years, with significant risk factors including male sex, high blood pressure, diabetes, previous CE history, and low creatinine clearance.
  • Patients who experienced new-onset CE had a much higher risk of major bleeding compared to those without CE, highlighting the need for careful management in elderly AF patients.
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Our case involved a 66-year-old woman who noticed progressive asymmetric involuntary movement, difficulty speaking, and difficulty swallowing. The patient fractured her femur due to a lower extremity involuntary movement while walking. During the course of her treatment for the fracture, her neurological symptoms worsened.

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Background: As members of a medical team, pharmacists are expected to provide optimal patient-centered, evidence-based pharmacotherapy. In Japan, in consideration of the importance of palliative care, a system was initiated for certifying palliative care pharmacists in 2010. However, no studies have evaluated the usefulness of board certification in palliative pharmacy.

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  • - The study analyzed the Japanese Adverse Drug Event Report database to examine respiratory depression caused by opioids in non-cancer patients, from April 2004 to February 2020.
  • - It found 22 combinations of opioids and administration routes that had a high frequency of reported respiratory depression, particularly noting transdermal buprenorphine and oral tramadol/acetaminophen in elderly patients.
  • - The research emphasizes the need for close monitoring of elderly patients starting opioid treatment for chronic non-cancer pain, especially within the first month, regardless of recommended starting doses.
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  • Polypharmacy, the simultaneous use of multiple medications, is a growing issue in cancer treatment, especially regarding the effects on oxycodone tolerability.
  • A study conducted across 20 hospitals examined the impact of drugs that inhibit liver enzymes CYP3A4 and CYP2D6 on oxycodone-related side effects during the first two weeks of treatment.
  • Results indicated that patients on multiple CYP3A4 inhibitors had a significantly higher incidence of nausea and vomiting (OINV), suggesting that careful management of concurrent medications is essential to minimize adverse effects.
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Cerebral response to emotional working memory based on vocal cues: an fNIRS study.

Front Hum Neurosci

December 2023

Applied Cognitive Neuroscience Laboratory, Faculty of Science and Engineering, Chuo University, Bunkyo, Japan.

Introduction: Humans mainly utilize visual and auditory information as a cue to infer others' emotions. Previous neuroimaging studies have shown the neural basis of memory processing based on facial expression, but few studies have examined it based on vocal cues. Thus, we aimed to investigate brain regions associated with emotional judgment based on vocal cues using an N-back task paradigm.

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Background: In the chain of survival for Out-of-hospital cardiac arrest (OHCA), each component of care contributes to improve the prognosis of the patient with OHCA. The SARS-CoV-2 (COVID-19) pandemic potentially affected each part of care in the chain of survival. The aim of this study was to compare prehospital care, in-hospital treatment, and outcomes among OHCA patients before and after the COVID-19 pandemic.

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Article Synopsis
  • A once-daily 15-mg dose of edoxaban has been approved for stroke prevention in patients aged ≥ 80 years with non-valvular atrial fibrillation (NVAF) at high bleeding risk (HBR) based on the ELDERCARE-AF trial.
  • The study analyzed 7346 NVAF patients, dividing them into three groups based on age and HBR status to investigate their characteristics and clinical outcomes.
  • Results showed that elderly NVAF patients with HBR (Group 3) had the highest risks for thromboembolism, major hemorrhage, and all-cause death during a 2-year follow-up, highlighting their need for careful management.
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Introduction: The spleen is a lymphatic organ that manages immune surveillance of the blood, produces blood cells, and helps filter the blood, remove old blood cells, and fight infection. The normal splenic weight is approximately 65-265 g. This study evaluated spleen volume and segmental volume.

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Background: Repeated triage training is necessary to maintain and improve the accuracy of simple triage and rapid treatment (START), a popular triage method. Virtual reality (VR) may be more effective than conventional training methods. This study aimed to verify the educational usefulness of START using VR originally developed for students.

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Objectives: Signs of life (SOLs) during cardiac arrest (gasping, pupillary light reaction, or any form of body movement) are suggested to be associated with favorable neurologic outcomes in out-of-hospital cardiac arrest (OHCA). While data has demonstrated that extracorporeal cardiopulmonary resuscitation (ECPR) can improve outcomes in cases of refractory cardiac arrest, it is expected that other contributing factors lead to positive outcomes. This study aimed to investigate whether SOL on arrival is associated with neurologic outcomes in patients with OHCA who have undergone ECPR.

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Article Synopsis
  • This study assessed echocardiographic features of left atrial (LA) structure and function in patients aged 75 and older with non-valvular atrial fibrillation (AF) to see how these features related to health outcomes over two years.
  • It involved 1,474 elderly patients, analyzing aspects like LA emptying fraction (LAEF) and maximum LA volume index (max. LAVi), revealing that lower LAEF and higher max. LAVi were linked to higher risks of cardiovascular events, heart failure hospitalizations, and overall mortality.
  • The findings suggest that elderly patients with poor LA function and larger LA volume need closer monitoring and management for better outcomes.
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In Japan, a low-dose transdermal fentanyl (TDF; 0.5 mg) has been approved to address pain in opioid-naïve patients with cancer; however, efficacy and safety data are lacking. To determine the efficacy and safety of TDF, patients with opioid-naïve cancer pain prescribed TDF (0.

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  • A large-scale study in Japan investigated the link between prenatal factors and congenital heart defects (CHD) in children, focusing on maternal characteristics and behaviors.
  • Analyzed data from 91,664 single births, the study found that specific factors such as vitamin A supplement use, certain medications, maternal age, and high hemoglobin levels were significantly associated with an increased risk of CHD.
  • The findings highlight the importance of various maternal health aspects during pregnancy and their potential influence on heart defects in children.
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Background: The aim of this study was to investigate the prognostic impact of postoperative infections in patients who underwent resection for biliary malignancy, including intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, distal cholangiocarcinoma, gallbladder carcinoma, and carcinoma of the ampulla of Vater.

Methods: This study was conducted in an 11-center retrospective cohort study. Patients with biliary tract cancer who underwent curative resection between April 2013 and March 2015 at 11 institutions in Japan were enrolled.

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Background: Long-term maintenance steroid therapy (MST) is frequently required for repeated relapses of cryptogenic organizing pneumonia (COP); however, the optimal minimal dose has not been clarified. Therefore, this study evaluated the minimal MST dose required to prevent repeated relapses and identify relapse predictors.

Methods: We retrospectively reviewed the medical records of patients with steroid-treated COP and compared background factors between the non-relapse and relapse groups.

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Characteristics of healthy Japanese young adults with respect to recognition of facial expressions: a preliminary study.

BMC Psychol

August 2023

Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, 113-8603, Japan.

Background: Emotional cognitive impairment is a core phenotype of the clinical symptoms of psychiatric disorders. The ability to measure emotional cognition is useful for assessing neurodegenerative conditions and treatment responses. However, certain factors such as culture, gender, and generation influence emotional recognition, and these differences require examination.

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Objective: After Endoscopic Sinus Surgery (ESS), packing plays an important role in wound healing and hemostasis. However, the effect of the packing removal procedure on physician stress has not been evaluated. The purpose of this study was to evaluate physician stress during packing removal for patients treated with AQUACEL® Ag Advantage versus KALTOSTAT®.

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Eosinophilic bronchiolitis is a disease concept reported in Japan in 2001, that presents with bronchiolitis accompanied by eosinophilia in the blood and lungs. In 2013, hypereosinophilic obliterative bronchiolitis, as a group of disease presenting with eosinophilic bronchiolitis, was proposed in France. The relationship between eosinophilic bronchiolitis and other eosinophil-related diseases has not been clarified.

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Objective: The odor recognition thresholds in T&T olfactometry are measured by either the examiner's judgment of the patients' odor expression for each standard odor or by the patient's choice of the correct response from an olfactory term table. This study aimed to clarify the correct odor expressions and use of the olfactory term table.

Methods: A questionnaire was administered to otolaryngologists or medical staff in charge of testing at facilities where T&T olfactometry is performed.

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Evaluation of splenic infarction ratio and platelet increase ratio after partial splenic artery embolization.

J Int Med Res

August 2023

Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, 1-5-1, Sendagi, Bunkyo-ku, Tokyo, Japan.

Objective: The spleen is part of the lymphatic system and is one of the least understood organs of the human body. It is involved in the production of blood cells and helps filter the blood, remove old blood cells, and fight infection. Partial splenic artery embolization (PSE) is widely used to treat pancytopenia and portal hypertension.

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Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been followed by many reports of the development and relapse of autoimmune diseases associated with SARS-CoV-2 vaccination. Some of these reports have involved relapse or onset of immunoglobulin A (IgA) nephropathy following SARS-CoV-2 vaccination. Here, we report on a patient with IgA nephropathy who presented with gross hematuria and rapidly progressive glomerulonephritis following SARS-CoV-2 vaccination.

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Article Synopsis
  • A study of over 30,000 elderly Japanese patients with nonvalvular atrial fibrillation (NVAF) found that many had low comprehension of their condition, which was linked to poorer health outcomes.
  • Among 1,968 patients assessed for understanding NVAF, 81.9% scored low, which was associated with a higher risk of serious complications like stroke and death.
  • Additionally, while 64.9% of the 2,362 patients showed good adherence to anticoagulant therapy, those who were less adherent faced significantly worse prognoses and clinical outcomes.
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