2 results match your criteria: "Nagano University Health and Medicine[Affiliation]"
Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging.
Am J Pathol
June 2023
Department of Neuro-health Innovation, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan; Community Health Care Research Centre, Nagano University Health and Medicine, Nagano, Japan.
Spontaneous and age-related amyloidosis has been reported in C57BL/6J mice. However, the biochemical characteristics of age-related amyloidosis remain unclear. Herein, the age-related prevalence of amyloidosis, the types of amyloid fibril proteins, and the effects of amyloid deposition were investigated in renal function in C57BL/6J mice.
View Article and Find Full Text PDFExercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
Dis Model Mech
March 2022
Department of Neuro-health Innovation, Institute for Biomedical Sciences, Shinshu University, Matsumoto 390-8621, Japan.
Exercise interventions are beneficial for reducing the risk of age-related diseases, including amyloidosis, but the underlying molecular links remain unclear. Here, we investigated the protective role of interval exercise training in a mouse model of age-related systemic apolipoprotein A-II amyloidosis (AApoAII) and identified potential mechanisms. Mice subjected to 16 weeks of exercise showed improved whole-body physiologic functions and exhibited substantial inhibition of amyloidosis, particularly in the liver and spleen.
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