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The rate of spontaneous mutations in human myeloid cells.
Mutat Res
September 2013
Division of Hematology, Department of Veterans Affairs New York Harbor Healthcare System, United States; Division of Hematology, Department of Medicine, NYU School of Medicine and the NYU Langone Cancer Center, United States. Electronic address:
The mutation rate (μ) is likely to be a key parameter in leukemogenesis, but historically, it has been difficult to measure in humans. The PIG-A gene has some advantages for the detection of spontaneous mutations because it is X-linked, and therefore only one mutation is required to disrupt its function. Furthermore, the PIG-A-null phenotype is readily detected by flow cytometry.
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