755 results match your criteria: "NY KP; New York Presbyterian Hospital[Affiliation]"

Saliby et al. show that a machine learning approach can accurately classify clear cell renal cell carcinoma (RCC) into distinct molecular subtypes using transcriptomic data. When applied to tumors biospecimens from the JAVELIN Renal 101 (JR101) trial, a benefit is observed with immune checkpoint inhibitor (ICI)-based therapy across all molecular subtypes.

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Study Design: Non-interventional, cross-sectional pilot study.

Objectives: To establish the validity and reliability of the BioStamp nPoint biosensor (Medidata Solutions, New York, NY, USA [formerly MC10, Inc.]) for measuring electromyography in individuals with cervical spinal cord injury (SCI) by comparing the surface electromyography (sEMG) metrics with the Trigno wireless electromyography system (Delsys, Natick, MA, USA).

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Objective: To investigate the source and transmission dynamics of an endoscope-associated New Delhi metallo-β-lactamase-producing (NDM-KP) outbreak.

Design: Epidemiological and genomic investigation.

Setting: Academic acute care hospital in New Jersey.

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Single-cell genomics and regulatory networks for 388 human brains.

bioRxiv

March 2024

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.

Article Synopsis
  • - Single-cell genomics helps us study diverse brain tissues, revealing how genetic variants affect gene expression at the cell level through an analysis of over 2.8 million nuclei from the prefrontal cortex across 388 individuals.
  • - Researchers identified more than 550,000 specific regulatory elements and over 1.4 million expression-quantitative-trait loci linked to various cell types, allowing them to develop networks that illustrate the impact of aging and neuropsychiatric disorders on cellular changes.
  • - An integrative model was created to predict single-cell gene expression and simulate cellular changes, which identified around 250 genes associated with disease risk and relevant drug targets tied to specific cell types.
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Article Synopsis
  • DESTINY-Lung01 is a phase 2 study investigating the effectiveness and safety of trastuzumab deruxtecan for patients with HER2-overexpressing non-small-cell lung cancer (NSCLC) who cannot undergo surgery or have metastases.
  • The study involved patients aged 18 and older, treated at 20 hospitals across multiple countries, with a specific focus on those whose cancer had progressed despite standard treatments and had certain HER2 immunohistochemistry scores.
  • A total of 49 patients were enrolled in the first treatment cohort, receiving either 5.4 mg/kg or 6.4 mg/kg doses of the drug every three weeks, with their response rates and safety being key focus points of the analysis.
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Background: Vertebral compression fractures (VCFs) can affect the entire spinopelvic complex and cause unpredictable patterns of back pain due to their effects on spinal tensegrity and biomechanical compensation. They can lead to significant morbidity and mortality in the aging population and are difficult to diagnose. We aimed to establish a relationship between VCFs and sacroiliac (SI) joint pain.

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Lessons Learned in Building Expertly Annotated Multi-Institution Datasets and Hosting the RSNA AI Challenges.

Radiol Artif Intell

May 2024

From the Department of Applied Innovation and AI, Dasa, São Paulo, Brazil (F.C.K.); Department of Diagnostic Imaging, Universidade Federal de São Paulo (Unifesp), Av Prof Ascendino Reis, 1245, 131, São Paulo, SP, Brazil 04027-000 (F.C.K.); Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio (L.M.P.); Department of Medical Imaging, University of Toronto, Toronto, Canada (E.C.); Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (S.S.H.); Microsoft HLS, Redmond, Wash (M.P.L.); Department of Biomedical Data Science, Stanford University, Stanford, Calif (M.P.L.); The Jackson Laboratory, Bar Harbor, Maine (R.L.B.); Department of Ophthalmology, University of Colorado Denver School of Medicine, Aurora, Colo (J.K.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (C.E.K.); Department of Radiology, University of Utah, Salt Lake City, Utah (T.R.); Department of Radiology and Biomedical Imaging (M.P.L., J.F.T., J.M.) and Center for Intelligent Imaging (J.M.), University of California San Francisco, San Francisco, Calif; Department of Radiology, Weill Cornell Medical College, New York, NY (G.S.); Department of Medical Imaging, Unity Health Toronto, Toronto, Canada (H.M.L.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, MGB Data Science Office, Boston, Mass (K.P.A.); Informatics Department, Radiological Society of North America, Oak Brook, Ill (M.V.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); and Department of Radiology, Thomas Jefferson University, Philadelphia, Pa (A.E.F.).

The Radiological Society of North America (RSNA) has held artificial intelligence competitions to tackle real-world medical imaging problems at least annually since 2017. This article examines the challenges and processes involved in organizing these competitions, with a specific emphasis on the creation and curation of high-quality datasets. The collection of diverse and representative medical imaging data involves dealing with issues of patient privacy and data security.

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Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of the vagus nerve activates the inflammatory reflex and has been shown to inhibit the production and release of inflammatory cytokines and decrease clinical signs and symptoms in RA. The RESET-RA study was designed to determine the safety and efficacy of an active implantable device for treating RA.

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Drop the shortcuts: image augmentation improves fairness and decreases AI detection of race and other demographics from medical images.

EBioMedicine

April 2024

Laboratory for Computational Physiology, Massachusetts Institute of Technology, Cambridge, MA, USA; Division of Pulmonary Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: It has been shown that AI models can learn race on medical images, leading to algorithmic bias. Our aim in this study was to enhance the fairness of medical image models by eliminating bias related to race, age, and sex. We hypothesise models may be learning demographics via shortcut learning and combat this using image augmentation.

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The COVID-19 pandemic necessitated a rapid shift in clinical research to perform virtual visits and remote endpoint assessments, providing a key opportunity to optimize the use of remote endpoints for clinical trials in cystic fibrosis. The use of remote endpoints could allow more diverse participation in clinical trials while minimizing participant burden but must be robustly evaluated to ensure adequate performance and feasibility. In response, the Cystic Fibrosis Foundation convened the Remote Endpoint Task Force (Supplemental Table 1), a multidisciplinary group of CF researchers with remote endpoint expertise and community members tasked to better understand the current and future use of remote endpoints for clinical research.

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Patients with acute myeloid leukemia (AML) often undergo physical decline leading to negative outcomes. Identification of distinct trajectories may help guide clinical decision-making and supportive care interventions. We built group-based trajectory models (GBTM) to find trajectories of change in the Functional Assessment of Cancer Therapy Physical Well-Being (FACT-PWB) subscale (up to 5 time points over 0 to 200 days of follow-up) using data from adults with newly diagnosed AML in 4 supportive care studies.

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Background: Chimeric antigen receptor T-cell therapy idecabtagene vicleucel (ide-cel) showed significantly improved progression-free survival compared with standard regimens in adults with relapsed and refractory multiple myeloma who had received two to four previous regimens in the ongoing phase 3 KarMMa-3 trial (NCT03651128). This study analysed patient-reported outcomes (PROs), a KarMMa-3 secondary endpoint.

Methods: In the randomised, open-label, phase 3 KarMMa-3 trial, 386 patients in hospitals (≥18 years of age, with measurable disease and an Eastern Cooperative Oncology Group performance status score of 0 or 1, who had received two to four previous regimens-including an immunomodulatory agent, a proteasome inhibitor, and daratumumab-and had documented disease progression after receiving their last dose of the last therapy) were randomly assigned to ide-cel (n=254) or standard regimens (daratumumab, pomalidomide, and dexamethasone; daratumumab, bortezomib, and dexamethasone; ixazomib, lenalidomide, and dexamethasone; carfilzomib and dexamethasone; or elotuzumab, pomalidomide, and dexamethasone; n=132).

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Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis.

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Background Dental caries is the most prevalent polymicrobial oral infectious disease tormenting individuals' healthy lifestyles and presents a significant public health problem. The objective of this study was to evaluate and compare the antibacterial properties of different concentrations of bamboo shoot ethanol extract with chlorhexidine mouth rinse on isolates of salivary ) and () Materials and methods Non-stimulated salivary samples from 30 young adults were treated ex vivo with bamboo shoot ethanolic extract at concentrations of 30 µg/ml, 40 µg/ml, 50 µg/ml, and 60 µg/ml. The colony-forming units were quantified by measuring the number of viable bacterial cells.

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Article Synopsis
  • Recent advancements in PSMA-targeted radiopharmaceuticals, specifically [F]AlF-P16-093, have improved PET imaging for prostate cancer, enhancing accuracy in staging the disease.
  • A custom automated synthesis platform produced over 15 GBq of [F]AlF-P16-093, achieving a radiochemical yield of about 52% and high purity.
  • The final product formulation shows stability, with a minimal decline in radiochemical purity when stored correctly, indicating potential for clinical use.
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This paper presents a cost-effective, quantitative, point-of-care solution for urinalysis screening, specifically targeting nitrite, protein, creatinine, and pH in urine samples. Detecting nitrite is crucial for the early identification of urinary tract infections (UTIs), while regularly measuring urinary protein-to-creatinine (UPC) ratios aids in managing kidney health. To address these needs, we developed a portable, transmission-based colorimeter using readily available components, controllable via a smartphone application through Bluetooth.

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Innovations in cardiac imaging have fundamentally advanced the understanding and treatment of cardiovascular disease. These advances in noninvasive cardiac imaging have also expanded the role of the cardiac imager and dramatically increased the demand for imagers who are cross-trained in multiple modalities. However, we hypothesize that there is significant variation in the availability of cardiac imaging expertise and a disparity in the adoption of advanced imaging technologies across the United States.

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Chimeric antigen receptor T-cell (CAR-T) therapies offer substantial advancement in the treatment of multiple myeloma (MM). However, the CAR-T therapy process involves complex decision-making that is informed by many variables. This review aims to provide an overview of the patient selection and administration process for CAR-T therapy for MM from the perspective of experienced healthcare providers (HCPs), including considerations for each step in the CAR-T therapy process.

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Background: We report long-term, end-of-study program safety outcomes from 25 randomized clinical trials (RCTs) in adult patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA) [including ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA)] who received ≥ 1 dose of Ixekizumab (IXE) over 5 years (PsO) or up to 3 years (PsA, axSpA).

Methods: This integrated safety analysis consists of data from patients who received any dose of IXE, across 25 RCTs (17 PsO, 4 PsA, 4 axSpA). Rates of treatment-emergent adverse events (TEAEs), serious adverse events (SAEs) and selected adverse events (AEs) of interest were analyzed for all pooled studies by years of therapy and overall, through March 2022.

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Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study.

Stroke

April 2024

Department of Neurology, The Warren Alpert Medical School of Brown University, Brown Medical School, Providence, RI (S. Yaghi, L.S., D. Mandel, K.P., V.D., K.B., T.B., N.K., F. Khan, C.S., N.M., E.G., K.F.).

Background: Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in patients with cervical artery dissection treated with antiplatelets versus anticoagulation.

Methods: This is a multicenter observational retrospective international study (16 countries, 63 sites) that included patients with cervical artery dissection without major trauma.

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Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major contributor to the declining efficacy of antibiotics through both acquired resistance and tolerance. In this study, a pan-drug resistant (PDR), NDM-1 and CTX-M-15 co-producing isolate of K.

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Article Synopsis
  • Multiple myeloma is a type of cancer that affects the bone marrow and has a 5-year survival rate of about 60%, but there are challenges with treatment.
  • Researchers are focusing on a new target in the fight against this cancer called GPRC5D, which could help make therapies more effective.
  • Early trials with GPRC5D-targeting treatments show promising results, with many patients responding well and experiencing fewer infections compared to other treatments, but some side effects related to skin and mouth have been observed.
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The selective removal of dysfunctional mitochondria, a process termed mitophagy, is critical for cellular health and impairments have been linked to aging, Parkinson disease, and other neurodegenerative conditions. A central mitophagy pathway is orchestrated by the ubiquitin (Ub) kinase PINK1 together with the E3 Ub ligase PRKN/Parkin. The decoration of damaged mitochondrial domains with phosphorylated Ub (p-S65-Ub) mediates their elimination though the autophagy system.

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Background: There is a lack of registry studies about transradial access (TRA) outcomes. This prospective registry evaluated the TRA and procedure outcomes of visceral embolizations performed via TRA with 30-day follow-up.

Material & Methods: Prospective, multicenter registry included uterine fibroids (UFE), prostate artery (PAE), liver tumors (LT), and other hypervascular tumors (OHT) embolization performed in six US hospitals.

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