Common Problems Encountered During the Delivery of New Dentures Constructed by Dental Clinical Students at University Sains Islam Malaysia (USIM).

Background Dentures are one of the main treatments dentists deliver to restore the oral function and aesthetics of individuals with missing teeth. Clinical denture fabrication and manufacturing is one of the main training modules for undergraduates during dental clinical training. However, students often face problems during denture delivery due to multiple factors causing discomfort to patients, affecting the quality of the denture and the patient's adaptation period to the denture.

Knowledge, Attitudes, and Practices (KAP) of Postgraduate Medical Trainees Regarding Patient Care in Diabetes and Hypertension.

Background: Diabetes and hypertension are common chronic illnesses that need to be effectively managed. To improve patient outcomes, healthcare workers' knowledge, attitudes, and practices (KAP) are essential.

Objective: This study aimed to evaluate the KAP of postgraduate medical trainees regarding the management of diabetes and hypertension.

YouTube Videos: A Learning Tool for Periodontology Education.

Introduction Video-based learning has proved to be an effective tool for education and knowledge gain in all fields. YouTube is a free video-sharing website consisting of numerous educational and skill development videos; you can even create and upload your videos to share knowledge and experience with others. YouTube contains videos about simple button sewing to space rocket preparation.

Targeted detection of sequence variants in cell-free DNA from cerebrospinal fluid in pediatric central nervous system tumors.

The emergence of liquid biopsy technologies holds great promise in the cancer setting, including in pediatric central nervous system (CNS) tumors. In contrast to broad lower-depth sequencing, commonly referred to as low pass whole genome sequencing (WGS), targeted platforms with a higher depth of coverage have also been established. Here, we review targeted liquid biopsy techniques with applicability to pediatric CNS tumors.

Bees on the run: spp. (Microsporidia) in and related products, Italy.

Introduction: The decline of the European/western honeybee () population is on account of a plethora of microorganisms, such as and , two microsporidian fungi responsible of nosemosis that affects welfare and production of the bee industry. Accordingly, this study aimed to investigate the presence of both pathogens in bees, pollen and honey from apiaries in Southwestern Italy.

Methods: From March to July 2022 and 2023, apiaries ( = 10) were selected and classified as High Impact Areas (HIAs,  = 5) and Low Impact Areas (LIAs,  = 5) according to a 5-point environmental risk index based on factors affecting bee health sand related productions.

Men's Attitudes Towards Participation in Organised Prostate Cancer Testing: An Abductive Thematic Analysis.

Background And Objective: Organised prostate cancer (PCa) testing (OPT) was introduced in Sweden to gain knowledge in preparation for a potential national PCa screening programme. This study aims to explore men's opinions regarding the OPT invitation letters and the attitudes influencing their decision to participate in or decline OPT.

Methods: We conducted semi-structured telephone interviews with 30 men (nine participants and 21 non-participants) from Stockholm County who received OPT invitations.

Education Research: Making a Tweetorial Fly: Features of Educational Social Media Posts Associated With High Sharing and Engagement.

Background And Objectives: Social media platforms such as X (formerly Twitter) are increasingly used in medical education. Characteristics of tweetorials (threaded teaching posts) associated with higher degrees of engagement are unknown. We sought to understand features of neurology-themed tweetorials associated with high sharing and engagement.

Education Research: Use by Neurologists of Microteaching and Microassessment Programs for Teaching, Learning, and Patient Care Needs: A Qualitative Study.

Background And Objectives: Microlearning is the acquisition of knowledge or skills in small units, commonly delivered by digital technology. NeuroBytes (NB) and Question of the Day (QOD) are 2 microinstructional programs in neurology. NB programs are brief, video-based mini-courses on clinical topics (microteaching); QODs are daily multiple-choice questions (microassessment).

Education Research: Trends of Neurology Clerkships in the United States Amidst a Global Pandemic.

Background And Objectives: To report a 2022 survey of US medical school neurology clerkship directors (CDs) and to compare the results with those of similar surveys conducted in 2005, 2012, and 2017.

Methods: An American Academy of Neurology (AAN) Consortium of Neurology Clerkship Directors (CNCD) workgroup developed the survey sent to all neurology CDs listed in the AAN CNCD database. Comparisons were made with 2005, 2012, and 2017 surveys.

A rare case of acrodysostosis type 2 with PDE4D mutation in a young female: a case report.

Acrodysostosis (ADO) is a rare form of peripheral dysostosis characterized by skeletal malformations, growth delays, short stature, and distinctive facial features caused by in part by underdeveloped (hypoplasia) of facial bones. Skeletal dysplasia is specific and includes disproportional short stature with short extremities and brachydactyly, multiple cone-shaped epiphyses, scoliosis or kyphosis with spinal stenosis, and advanced bone maturation. Herein, we are highlighting a case that presented with clinical features such as brachydactyly, delayed milestone, growth delay, muscle weakness and nasal hypoplasia.

Resilience Among Caregivers of People With Multiple Sclerosis: Exploring the Influence of Personality Traits, Coping, and Caregiver Burden.

Background: Resilience has been recognized as a vital protective factor in coping with stress and adversity. Multiple sclerosis (MS) caregiving is a complex and demanding role, often characterized by challenges.

Methods: Caregivers of people with MS were recruited through health care professionals affiliated with the Jacobs MS Center for Treatment and Research in Buffalo, New York.

What 'unexplored' means: mapping regions with digitized natural history records to look for 'biodiversity blindspots'.

We examined global records of accessible natural history voucher collections (with publicly available data and reliable locality data) for terrestrial and freshwater vascular plants, fungi, freshwater fishes, birds, mammals, and herpetofauna (amphibians and reptiles) and highlight areas of the world that would be considered undersampled and sometimes called 'unexplored' (., have relatively low, or no evidence of, past sampling efforts) under typical Western-scientific descriptions. We also question what 'unexplored' may mean in these contexts and explain how replacing the term in favor of more nuanced phrasing (.

SyncGenie: A programmable event synchronization device for neuroscience research.

In neuroscience, accurately correlating brain activity with stimuli and other events requires precise synchronization between neural data and event timing. To achieve this, purpose-built synchronization devices are often used to detect events. This paper introduces SyncGenie, a programmable synchronization device designed for a range of uses in neuroscience research-primarily as a "trigger box" to align neurophysiological data with physical stimulus events, among other possibilities.

A unique case of extranodal marginal zone lymphoma with synchronous pulmonary and dermatologic manifestations.

An 89-year-old male with a medical history of non-ischemic cardiomyopathy was initially admitted with acute hypoxic respiratory failure attributed to heart failure exacerbation. Aside from progressive dyspnea, a non-pruritic, non-painful rash and constitutional symptoms were reported. Initial work-up was remarkable for normocytic anemia, lymphopenia, mild hypercalcemia, and elevated inflammatory markers.

An agent-based model facilitating stakeholder engagement in management of estuaries along the Texas Gulf Coast (USA).

We describe an agent-based model purposed for social learning, which was developed by stakeholders, with the technical assistance of professional modelers, to facilitate stakeholder involvement in modeling issues related to the development of an adaptive environmental management plan for the Texas Gulf Coast (USA) estuaries. Stakeholders developed the model during six workshops that spanned a three-year period, and used the model to simulate the population dynamics (recruitment, growth, movement, and mortality) of blue crabs () in the Aransas and Copano Bays in response to various freshwater inflow and harvest scenarios. Results of scenarios representing normal, low, and high harvest levels indicated little effect on blue crab abundances, but harvests increased ≈75 % when harvest level was doubled and decreased ≈50 % harvest level was halved.

Speech-Language Pathology Interventions in Pediatric Awake Brain Surgery: A Moroccan and Global Perspective.

Introduction Awake brain surgery (ABS) is a groundbreaking technique that not only enhances tumor resection but also preserves vital neurocognitive functions, particularly through advanced brain mapping. Despite its success in adults, ABS in pediatric patients remains significantly underexplored, especially concerning the role of speech-language pathology (SLP) in these procedures. This study addresses this gap by providing a thorough examination of SLP interventions in pediatric ABS across various university hospitals, including those in Morocco and internationally.

Prevalence of Osteoporosis and Osteopenia in Patients With Type 2 Diabetes at King Abdulaziz University Hospital: A Retrospective Analysis.

Introduction Osteoporosis mainly affects postmenopausal women and is characterized by decreasing bone mass and an increased risk of fracture. As populations age, it becomes more common and is frequently missed until fractures happen. Simultaneously, there is conflicting evidence about the relationship between bone health and diabetes, a chronic metabolic illness, with varying effects on the skeletal system.

for an automated quantitative analysis of fibers orientation and organization in biological fibrous tissues.

Many biological fibrous tissues exhibit distinctive mechanical properties arising from their highly organized fibrous structure. In disease conditions, alterations in the primary components of these fibers, such as type I collagen molecules in bone, tendons, and ligaments, assembly into a disorganized fibers architecture generating a weak and/or brittle material. Being able to quantitatively assess the fibers orientation and organization in biological tissue may help improve our understanding of their contribution to the tissue and organ mechanical integrity, and assess disease progress and therapy effect.

Comparing quantitative imaging biomarker alliance volumetric CT classifications with RECIST response categories.

Purpose: To assess agreement between CT volumetry change classifications derived from Quantitative Imaging Biomarker Alliance Profile cut-points (ie, QIBA CTvol classifications) and the Response Evaluation Criteria in Solid Tumors (RECIST) categories.

Materials And Methods: Target lesions in lung, liver, and lymph nodes were randomly chosen from patients in 10 historical clinical trials for various cancers, ensuring a balanced representation of lesion types, diameter ranges described in the QIBA Profile, and variations in change magnitudes. Three radiologists independently segmented these lesions at baseline and follow-up scans using 2 software tools.

Heterogeneity and therapeutic implications of cancer-associated fibroblasts in lung cancer: Recent advances and future perspectives.

Lung cancer is a leading cause of cancer-related mortality. The tumor microenvironment is a complex and heterogeneous cellular environment surrounding tumor cells, including cancer-associated fibroblasts (CAFs), blood vessels, immune cells, the extracellular matrix, and various cytokines secreted by cells. CAFs are highly heterogeneous and play crucial roles in lung cancer.

Intravenous Steroids Do Not Improve Short-Term Outcomes of Patients With Crohn's Disease Presenting With an Acute Small Bowel Obstruction.

Background: Intravenous (IV) steroids are commonly used to treat acute flares of Crohn's disease (CD). However, it is unclear if they are beneficial in the setting of uncomplicated small bowel obstruction (SBO). We sought to examine if IV steroid administration improved short-term outcomes in patients with CD hospitalized for acute, uncomplicated SBO across three New York City hospital systems.

Factors Influencing Adolescent COVID-19 Vaccination During the Omicron Surge.

While most adolescents experience mild-COVID-19 infection, those with underlying medical conditions have an increased risk of severe health outcomes. Furthermore, compared with other pediatric populations, adolescents have experienced higher rates of COVID-19-associated hospitalization. COVID-19 vaccine decision-making in adolescents during COVID-19 surges is not well understood.

DISCOntinuation of disease-modifying therapies in MS: The DISCOMS extension trial.

Background: In the DISCOMS (DISCOntinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS)) randomized clinical trial, we could not demonstrate that discontinuing MS DMTs in older, stable adults was not inferior to continuing DMTs. Relapses were rare in both groups, and most new disease activity was one to two new brain magnetic resonance imaging (MRI) lesions unassociated with clinical changes.

Objective/aims: Describe results of the DISCOMS extension study.

Cosmology of belonging: The role of community in the therapeutic use of psychedelics.

Background: The recent wave of clinical trials of psychedelic substances among patients with life-limiting illness has largely focused on individual healing. This most often translates to a single patient receiving an intervention with researchers guiding them. As social isolation and lack of connection are major drivers of current mental health crises and group work is expected to be an important aspect of psychedelic assisted psychotherapy, it is essential that we understand the role of community in psychedelic healing.