Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2.

Background: Patient-derived lung cancer organoids (PD-LCOs) demonstrate exceptional potential in preclinical testing and serve as a promising model for the multimodal management of lung cancer. However, certain lung cancer cells derived from patients exhibit limited capacity to generate organoids due to inter-tumor or intra-tumor variability. To overcome this limitation, we have created an in vitro system that employs mesenchymal stromal cells (MSCs) or fibroblasts to serve as a supportive scaffold for lung cancer cells that do not form organoids.

Country economic status is strongly associated with burn survival - validation of the (modified) ABSI.

Background: Predicting burn-related mortality is vital for family counseling, triage, and resource allocation. Several of the burn-specific mortality prediction scores have been developed, including the Abbreviated Burn Severity Index (ABSI) in 1982. However, these scores are not tested for accuracy to support contemporary estimates of the global burden of burn injury.

A novel homozygous intronic variant in CDT1 that alters splicing causes Meier-Gorlin syndrome, and a review of published mutations and growth hormone treatments.

Background: Meier-Gorlin syndrome (MGORS) is a rare autosomal inherited form of primordial dwarfism. Pathogenic variants in 13 genes involved in DNA replication initiation have been identified in this disease, but homozygous intronic variants have never been reported. Additionally, whether growth hormone (GH) treatment can increase the height of children with MGORS is unclear.

Construction of a nursing management program for early fluid resuscitation in patients with acute pancreatitis: a Delphi study in China.

Aim And Objectives: To construct a set of scientific and feasible nursing management protocols for early fluid resuscitation in acute pancreatitis (AP) patients that can be used to guide clinical practice and enhance the treatment efficacy in these patients.

Background: Fluid resuscitation is a key means of early treatment for AP patients and has become a clinical consensus. Nurses are important practitioners of fluid resuscitation, and there is a lack of specific enforceable nursing management programs.

Effects of sleep quality on the risk of various long COVID symptoms among older adults following infection: an observational study.

Background: The long-term sequelae of coronavirus disease 2019 (COVID-19) and its recovery have becoming significant public health concerns. Therefore, this study aimed to enhance the limited evidence regarding the relationship between sleep quality on long COVID among the older population aged 60 years or old.

Methods: Our study included 4,781 COVID-19 patients enrolled from April to May 2023, based on the Peking University Health Cohort.

Resistive memory-based zero-shot liquid state machine for multimodal event data learning.

The human brain is a complex spiking neural network (SNN) capable of learning multimodal signals in a zero-shot manner by generalizing existing knowledge. Remarkably, it maintains minimal power consumption through event-based signal propagation. However, replicating the human brain in neuromorphic hardware presents both hardware and software challenges.

Relationship between VEGF to PEDF ratio and in-hospital mortality in acute respiratory distress syndrome patients.

Acute respiratory distress syndrome (ARDS) has a high mortality rate worldwide; thus, identifying death risk factors related to ARDS is critical for risk stratification in patients with ARDS. In the present study, we conducted a single-center retrospective cohort analysis. Out of 278 patients with ARDS admitted from January 2016 to June 2022, 226 were included in this study.

Infrared spectroscopic study on residual chitosan-based composite seed coating in kaolin.

The decomposition of residual chitosan-based composite seed coating in kaolin under different temperatures and salinities is analyzed with a Fourier transform infrared spectroscopy (FT-IR). The degradation cycle is 28 days. The results show that a residue of the chitosan-based composite seed coating still exists in the kaolin on Day 7.

The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells.

The nuclear matrix, a proteinaceous gel composed of proteins and RNA, is an important nuclear structure that supports chromatin architecture, but its role in human pluripotent stem cells (hPSCs) has not been described. Here we show that by disrupting heterogeneous nuclear ribonucleoprotein U (HNRNPU) or the nuclear matrix protein, Matrin-3, primed hPSCs adopted features of the naive pluripotent state, including morphology and upregulation of naive-specific marker genes. We demonstrate that HNRNPU depletion leads to increased chromatin accessibility, reduced DNA contacts and increased nuclear size.

Joint response of surface subsidence and strong mine earthquake under high-positioned and thick-hard strata in deep coal mine.

Multiple active mining faces and extensive excavations under thick-hard strata in deep coal mines result in frequent strong mine earthquakes, often accompanied by significant surface subsidence deformation. Understanding the specific law of surface movement and the spatiotemporal distribution response to intense mine earthquakes is crucial for effectively preventing and mitigating dynamic disasters in deep mines. Utilizing the key layer theory, the intricate strata of the Yingpanhao Coal Mine are systematically delineated, drawing upon the engineering context of working faces 2201 and 2202 within the Ordos Chemical Co.

Chemically engineered antibodies for autophagy-based receptor degradation.

Cell surface receptor-targeted protein degraders hold promise for drug discovery. However, their application is restricted because of the complexity of creating bifunctional degraders and the reliance on specific lysosome-shuttling receptors or E3 ubiquitin ligases. To address these limitations, we developed an autophagy-based plasma membrane protein degradation platform, which we term AUTABs (autophagy-inducing antibodies).

The trophic distribution of biomass in ecosystems with co-occurring wildlife and livestock.

Trophic interactions regulate populations, but anthropogenic processes influence primary productivity and consumption by both herbivore and carnivore species. Trophic ecology studies often focus on natural systems such as protected areas, even though livestock globally comprise the majority of terrestrial vertebrate biomass. Here we explore spatial and temporal patterns in the distribution of biomass between plants, and large herbivores and carnivores (> 10 kg) in Norwegian rangelands, including both wildlife and livestock.

Association between overt hepatic encephalopathy and liver pathology after transjugular intrahepatic portosystemic shunt creation in cirrhotic patients.

To investigate the association between overt hepatic encephalopathy (OHE) and liver pathology after transjugular intrahepatic portosystemic shunt (TIPS) creation in cirrhotic patients. From July 2015 to April 2024, 73 patients from 4 hospitals in China who received TIPS creation and liver biopsy were retrospectively enrolled in this study. Based on whether OHE occurred within 3 months after TIPS creation, the patients were categorized into OHE (n = 29) and non-OHE (n = 44) groups.

The lightweight design of steel pistons for diesel engines based on thermo-mechanical characteristics.

Traditional aluminum-silicon alloy pistons are gradually replaced by steel pistons, which has become the trend of future diesel engine development. However, the efficient design and broad application of steel pistons are limited by the higher density of steel. For this reason, a new lightweight design method for steel pistons in diesel engines was proposed in this paper.

Optical soliton solutions of the M-fractional paraxial wave equation.

This research used a modified and extended auxiliary mapping method to examine the optical soliton solutions of the truncated time M-fractional paraxial wave equation. We employed the truncated time M-fractional derivative to eliminate the fractional order in the governing model. The few optical wave examples of the paraxial wave condition can assume an insignificant part in depicting the elements of optical soliton arrangements in optics and photonics for the investigation of different actual cycles, including the engendering of light through optical frameworks like focal points, mirrors, and fiber optics.

Suppression of epileptic seizures by transcranial activation of K-selective channelrhodopsin.

Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While transcranial photoexcitation of neurons has been achieved, noninvasive optogenetic inhibition for treating hyperexcitability-induced neurological disorders has remained elusive.

Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17.

Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the dual-purpose SNARE complex mediating autophagosome-lysosome fusion in both bulk and selective autophagy. However, the spatiotemporal regulatory mechanisms of this SNARE complex remain unknown.

Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion.

Early antiretroviral therapy (ART) initiation is known to limit the establishment of the HIV reservoir, with studies suggesting benefits such as a reduced number of infected cells and a smaller latent reservoir. However, the long-term impact of early ART initiation on the dynamics of the infected cell pool remains unclear, and clinical evidence directly comparing proviral integration site counts between early and late ART initiation is limited. In this study, we used Linear Target Amplification-PCR (LTA-PCR) and Next Generation Sequencing to compare unique integration site (UIS) clonal counts between individuals who initiated ART during acute HIV infection stage (Acute-ART group) and those in the AIDS stage (AIDS-ART group).

Interfacial Oxygen Vacancy-Copper Pair Sites on Inverse CeO2/Cu Catalyst Enable Efficient CO2 Electroreduction to Ethanol in Acid.

Renewable electricity-driven electrochemical reduction of CO2 offers a promising route for production of high-value ethanol. However, the current state of this technology is hindered by low selectivity and productivity, primarily due to limited understanding of the atomic-level active sites involved in ethanol formation. Herein, we identify that the interfacial oxygen vacancy-neighboring Cu (Ov-Cu) pair sites are the active sites for CO2 electroreduction to ethanol.

Nano-formulated Pyraclostrobin with Iron Bismuthide Enhances Efficient Utilization of Active Ingredient and Improves Biosafety.

The widespread application of pyraclostrobin (PYR), an important strobilurin fungicide with low utilization efficiency, urgently requires optimization for sustainable agriculture. In this study, nanoformulated PYR with nano-iron bismuthide (FeBi) was successfully prepared via flash nanoprecipitation, yielding spherical PYR/FeBi nanoparticles (NPs, Φ120 nm) with stable drug loading capacity (67.9%) and controlled release.

Nursing practices for a patient with ALK-negative anaplastic large cell lymphoma with a cancerous wound: a case report.

Background: Cancerous wounds are a significant challenge in cancer care, reducing the quality of life and affecting psychological well-being.

Purpose: This case report describes a 59-year-old female who developed a severe cancerous wound. The report presents comprehensive nursing measures for patients with cancerous wounds and discusses key nursing factors that promote wound healing.

Data-model interactive Rul prediction of stochastic degradation devices with multiple uncertainty quantification and multi-sensor information fusion.

This paper proposes an improved remaining useful life (RUL) prediction method for stochastic degradation devices monitored by multi-source sensors under data-model interactive framework. Firstly, the interrelationships among sensors are established using k-nearest neighbor (KNN), and the composite health index (CHI) is constructed by aggregating the multi-source sensor information through the graph convolutional network (GCN). Secondly, a stochastic degradation model with triple uncertainty at any initial degradation level is established to improve the matching degree between the stochastic degradation model and the actual degradation process.

Identifying Protein-Nucleotide Binding Residues via Grouped Multi-task Learning and Pre-trained Protein Language Models.

The accurate identification of protein-nucleotide binding residues is crucial for protein function annotation and drug discovery. Numerous computational methods have been proposed to predict these binding residues, achieving remarkable performance. However, due to the limited availability and high variability of nucleotides, predicting binding residues for diverse nucleotides remains a significant challenge.