Anterior and Posterior Ocular Changes in Patients with Active and Inactive Ankylosing Spondylitis.

BACKGROUND The 6-item Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a method for evaluating disease activity in ankylosing spondylitis (AS). This study included 78 patients with active and inactive AS and aimed to evaluate anterior and posterior segment ocular changes. MATERIAL AND METHODS Seventy-eight patients and 70 control subjects were enrolled in this study.

Impact of irradiation conditions on therapy of Lewis lung carcinoma in mice using glucose-ethylenediamine carbon dots.

Background: nowadays, the photoacoustic imaging is in the mainstream of cancer theranostics. In this study the nanoparticles with previously proven photoacoustic imaging properties, i.e.

Biogenic synthesis of titanium nanoparticles by Streptomyces rubrolavendulae for sustainable management of Icerya aegyptiaca (Douglas).

Biosynthesized nanoparticles have a variety of applications, and microorganisms are considered one of the most ideal sources for the synthesis of green nanoparticles. Icerya aegyptiaca (Douglas) is a pest that has many generations per year and can affect 123 plant species from 49 families by absorbing sap from bark, forming honeydew, causing sooty mold, and attracting invasive ant species, leading to significant agricultural losses. The purpose of this work was to synthesize titanium dioxide nanoparticles (TiO-NPs) from marine actinobacteria and evaluate their insecticidal effects on Icerya aegyptiaca (Hemiptera: Monophlebidae), in addition to explaining their effects on protein electrophoresis analysis of SDS‒PAGE proteins from control and treated insects after 24, 72 and 120 h of exposure.

Enhanced antibody responses in CD19-Cre mice.

CD19-Cre is an important and widely used Cre-lox model for B cell-specific genetic manipulation in murine systems. Mice carrying one allele of CD19-Cre are, at the same time, rendered heterozygote for CD19, a crucial coreceptor of the B cell antigen receptor (BCR). As a result, CD19-Cre mice exhibit diminished expression levels of CD19, with potential, yet insufficiently examined, consequences in B cell activation.

Protective effects of resveratrol and naringenin against nonylphenol-induced oxidative stress in rats.

Nonylphenol (NP) is a ubiquitous environmental endocrine disrupting chemical and oxidative stress inducer in biological systems. Resveratrol (RES) and Naringenin (NG) are phytochemicals possessing antioxidant properties and estrogenic activity. This study was conducted to investigate the toxicity of NP and the mitigating effects of RES and NG on NP toxicity in rats.

The effects of nickel tungstate nanoparticles (NiWO NPs) on freshwater microalga Raphidocelis subcapitata (Chlorophyceae).

Among the vast array of functional nanoparticles (NPs) under development, nickel tungstate (NiWO) has gained prominence due to its potential applications as a catalyst, sensor, and in the development of supercapacitors. Consequently, new studies on the environmental impact of this material must be conducted to establish a regulatory framework for its management. This work aims to assess the effects of NiWO (NPs) on multiple endpoints (e.

Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis.

Congenital neutropenia (CoN) is a heterogeneous group of inborn errors of immunity (IEI) characterized by recurrent infections and early onset of neutropenia (NP). This study aimed to investigate the demographic and clinical data of children with CoN and idiopathic neutropenia (IN) in Morocco. We performed a retrospective study of patients with CoN and analyzed the clinical and laboratory findings of patients with CoN and IN diagnosed between 1999 and 2018 in a clinical immunology unit of a large pediatric hospital.

Single Precursor-Derived Sub-1 nm MoCo Bimetallic Particles Decorated on Phosphide-Carbon Nitride Framework for Sustainable Hydrogen Generation.

The strategic design and fabrication of efficient electrocatalysts are pivotal for advancing the field of electrochemical water splitting (EWS). To enhance EWS performance, integrating non-noble transition metal catalysts through a cooperative double metal incorporation strategy is important and offers a compelling alternative to conventional precious metal-based materials. This study introduces a novel, straightforward, single-step process for fabricating a bimetallic MoCo catalyst integrated within a three-dimensional (3D) nanoporous network of N, P-doped carbon nitride derived from a self-contained precursor.

Downregulation and inhibition of TRPM2 calcium channel prevent oxidative stress-induced endothelial dysfunction in the EA.hy926 endothelial cells model - Preliminary studies.

Purpose: Proper functioning of the endothelial barrier is crucial for cardiovascular system homeostasis. Oxidative stress can lead to endothelial dysfunction (ED), damaging lipids, proteins, and DNA. Reactive oxygen species also increase cytoplasmic Ca levels, activating transient receptor potential melastatin 2 (TRPM2), a membrane non-selective calcium channel.

A comprehensive analysis of serotype-specific invasive capacity, clinical presentations, and mortality trends of invasive pneumococcal disease.

Background: Pneumococcal conjugate vaccines (PCV) reduced invasive disease, but the overall prevalence of pneumococcal nasopharyngeal colonization among children has not changed significantly. Our knowledge of which serotypes, once colonized, hold a higher likelihood to cause invasive disease is limited.

Methods: Serotype-specific invasive capacity (IC) of Streptococcus pneumoniae was estimated using an enhanced population-based invasive pneumococcal disease (IPD) surveillance in children <7 years of age in Massachusetts and surveillance of nasopharyngeal (NP) colonization in selected Massachusetts communities in corresponding respiratory seasons.

The impacts of alien species on river bioassessment.

The extent of alien taxa impacts on river ecosystem health is unclear, but their frequency continues to rise. We investigated 1) the prevalence of including alien taxa in common bioindicators used in river bioassessment, 2) the effect of alien taxa on the richness and abundance of natives, and 3) whether including alien taxa in bioassessment tools increased their sensitivity to river degradation. In the 17 countries analyzed fish represented the greatest number of alien species (1726), followed by macrophytes (925), macroinvertebrates (556), and diatoms (7).

Date seeds polysaccharides as novel capping agents for selenium nanoparticles: Synthesis, characterization, stability, biological activities, and gut microbiota modulation.

Date seed polysaccharides were utilized to synthesize selenium nanoparticles (MPS-NP) through a redox reaction involving sodium selenite and ascorbic acid. Characterization of MPS-NP showed a uniform, amorphous, spherical shape with a particle size of 89.2 nm, remaining stable for 42 days.

Differentiated effects and mechanisms of N-, P-, S-, and Fe-modified biochar materials for remediating Cd- and Pb-contaminated calcareous soil.

To investigate the remediation effects of various modified biochar materials derived from different impregnation agents on Cd- and Pb-contaminated calcareous soil, nitrogen (N-), phosphorus (P-), sulfur (S-), and iron (Fe-) modified biochar materials (NBC, PBC, SBC, FBC) were fabricated through the impregnation-pyrolysis method and employed to immobilize Pb and Cd in the calcareous soil. The characterization results showed that NBC exhibited an uneven pore size distribution and increased aromaticity, while PBC and SBC had increased pH and ash content. Pot experiments demonstrated significantly different effects of various modified biochar materials on soil immobilization and plant uptake of Cd and Pb.

An Inanimate Intracorporeal Anastomosis Model With Real-Time Force Feedback: An Initial Study.

Introduction: Laparoscopic intestinal anastomosis requires specific technical skills and should be trained in a safe simulation environment before performing surgery in daily practice. However, anastomosis simulation training with objective feedback is not widely available. This study aimed to analyze a laparoscopic intestinal anastomosis training task that utilizes objective force, motion, and time measurements.

CO and Temperature Induced Switching of a Flexible Metal-Organic Framework with Surface-Mounted Nanoparticles.

Within the material family of metal-organic frameworks (MOFs) the subclass of flexible MOFs (flexMOFs) has attracted great attention, showing structural flexibility as a response to external stimuli such as guest adsorption, temperature, and pressure. Hybrid composites like nanoparticle (NP) loaded flexible MOFs, which stand to potentially combine advantageous properties of both are yet largely unexplored. Here the synthesis of flexMOFs with surface mounted nanoparticles, e.

Niche Partitioning and Intraspecific Variation of Thaumarchaeota in Deep Ocean Sediments.

Deep-sea sediments contain a large number of Thaumarchaeota that are phylogenetically distinct from their pelagic counterparts. However, their ecology and evolutionary adaptations are not well understood. Metagenomic analyses were conducted on samples from various depths of a 750-cm sediment core collected from the Mariana Trench Challenger Deep.

Colloidal High Entropy Alloy Nanoparticles: Synthetic Strategies and Electrocatalytic Properties.

High entropy alloy (HEA) nanoparticles (NPs) have attracted much attention recently due to their unprecedented chemical properties. As such, HEA NPs have been used as materials with superior activity toward electrocatalytic applications. Specifically, solid solutions that form randomly mixed single-phased structures have received the most focus in the early stages of HEA NP development for their entropic-driven design and multifunctionality.

New Rat Model Mimicking Sacrocolpopexy for POP Treatment and Biomaterials Testing via Unilateral Presacral Suspension.

Introduction And Hypothesis: Pelvic organ prolapse (POP) impacts women's health and quality of life. Post-surgery complications can be severe. This study uses rat models to replicate sacrocolpopexy and test materials for pelvic support, verifying the 4-week postoperative mortality rate, the mechanical properties of the mesh tissue, and the collagen content.

Research progress in neuropathic pain after spinal cord injury: a bibliometric study from 2013 to 2024.

Background: The incidence of neuropathic pain (NP) after spinal cord injury (SCI) is quite high. This pain is clinically challenging to treat and has an debilitating effect on patients. In recent years, NP is a popular topic of research and a number of relevant articles have been published in academic journals.

A 50-year data-driven model of disability and lesion load trajectories in progressive multiple sclerosis.

This scientific commentary refers to 'A data-driven model of disability progression in progressive multiple sclerosis', by Garbarino . (https://doi.org/10.

All Suture Biceps Tenodesis Has Greater Biomechanical Strength Than Metal Button Fixation.

Purpose: To evaluate the maximal load to failure, cyclic displacement, stiffness, and modes of failure of onlay subpectoral biceps tenodesis with an intramedullary unicortical metal button (MB) versus an inlay, all-suture Caspari-Weber (CW) technique.

Methods: Sixteen matched paired human cadaveric proximal humeri were randomly allocated for subpectoral BT with either CW or MB using a high-strength suture (N = 16; 8 male, 8 female, mean age = 82.5 years, range 62-99 years).

Changes in optical properties of aesthetic paediatric restorative materials following exposure to beverages: In-vitro study.

Purpose: Optical properties of recent aesthetic restorative materials must maintain an acceptable appearance throughout their functional lifetime. This study aimed to assess the changes in translucency and colour of recent resin-based restorative materials after exposure to beverages commonly consumed by children.

Methods: An experimental in-vitro study on 48 discs specimens prepared from; Group I: Filtek Z250 XT (Nanohybrid), Group II: Cention N (Alkasite bulkfill), and Group III: SDR flow Plus (Flowable bulkfill).

Osteoporosis in Older Men: Informing Patient Management and Improving Health-Related Outcomes.

Osteoporosis has been usually considered a female disease, generally causing more fracture risk and complications in adult and older women compared to older men. While vertebral fractures occur in a small proportion of men during middle age, men generally fracture about 10 years later than women, with significant increases in fracture risk after about age 75. Independent of age, men experiencing fragility fractures have a higher risk of life-threatening events compared to women, but the risk of secondary fragility fracture overlaps between men and women.

Interactive effects of salinity, redox, and colloids on greenhouse gas production and carbon mobility in coastal wetland soils.

Coastal wetlands, including freshwater systems near large lakes, rapidly bury carbon, but less is known about how they transport carbon either to marine and lake environments or to the atmosphere as greenhouse gases (GHGs) such as carbon dioxide and methane. This study examines how GHG production and organic matter (OM) mobility in coastal wetland soils vary with the availability of oxygen and other terminal electron acceptors. We also evaluated how OM and redox-sensitive species varied across different size fractions: particulates (0.

Hybrid Prairie Dog and Dwarf Mongoose optimization algorithm-based application placement and resource scheduling technique for fog computing environment.

The fog computing paradigm is better for creating delay-sensitive applications in Internet of Things (IoT). As the fog devices are resource constrained, the deployment of diversified IoT applications requires effective ways for determining available resources. Therefore, implementing an efficient resource management strategy is the optimal choice for satisfying application Quality of Service (QoS) requirements to preserve the system performance.