Exploring glioma heterogeneity through omics networks: from gene network discovery to causal insights and patient stratification.

Gliomas are primary malignant brain tumors with a typically poor prognosis, exhibiting significant heterogeneity across different cancer types. Each glioma type possesses distinct molecular characteristics determining patient prognosis and therapeutic options. This study aims to explore the molecular complexity of gliomas at the transcriptome level, employing a comprehensive approach grounded in network discovery.

Evaluating the capacity of tertiary general hospitals in Beijing to prevent and treat respiratory infectious diseases: a delphi study.

Background: The capacity of tertiary general hospitals to prevent and treat respiratory infectious diseases plays a key role in effectively containing the spread of major epidemics within hospitals and ensuring early treatment for patients. This, in turn, helps control the transmission of diseases at the societal level and safeguard public health. However, there is a lack of detailed indicators for assessing hospitals' capacity in this area, which makes it difficult to evaluate and manage practices.

Integration of spectroscopic techniques and machine learning for optimizing Phaeodactylum tricornutum cell and fucoxanthin productivity.

The development of sustainable and controlled microalgae bioprocesses relies on robust and rapid monitoring tools that facilitate continuous process optimization, ensuring high productivity and minimizing response times. In this work, we analyse the influence of medium formulation on the growth and productivity of axenic Phaeodactylum tricornutumcultures and use the resulting data to develop machine learning (ML) models based on spectroscopy. Our culture assays produced a comprehensive dataset of 255 observations, enabling us to train 55 (24+31) robust models that predict cells or fucoxanthin directly from either absorbance or 2D-fluorescence spectroscopy.

Buzz pollination: A theoretical analysis via scaling invariance.

Nearly half of the bee species can perform a fascinating stereotyped behavior to collect pollen grains by vibrating flowers, known as buzz pollination. During the floral visit, these bees mechanically transfer the vibrations produced by their thoracic indirect flight muscles to the flower anther, inducing the movement of the pollen grains and leading them to be released through a small pore or slit placed at the tip of the anther in poricidal flowers. In such flowers, pollen release is affected by the vibrational behavior of buzzing bees, primarily their duration and velocity amplitude.

An Approach for Modeling and Simulation of Virtual Sensors in Automatic Control Systems Using Game Engines and Machine Learning.

We live in an era characterized by Society 4.0 and Industry 4.0 where successive innovations that are more or less disruptive are occurring.

Amber "Alchemy": Recreating and Investigating Yellow Glass Formulations.

Amber glass has been produced since at least the 6th century BC. Its value derives from its ability to mimic natural amber and, later, from its ultraviolet filtering properties. Until the 19th century, amber glass was widely used for the storage of food and medicines because its protective properties had been empirically recognized.

Association of Gut Microbiome and Dipeptidyl Peptidase 4 in Immune-Mediated Inflammatory Bowel Disease: A Rapid Literature Review.

Immune-mediated inflammatory diseases (IMIDs) are characterized by dysregulated immune responses and chronic tissue inflammation. In the setting of inflammatory bowel disease (IBD), dipeptidyl peptidase 4 (DPP4) and gut microorganisms have been proved to interplay, potentially influenced by dietary factors. This rapid review aimed to study the DPP4-gut microbiome link in IBD.

Gluten-Free Sweet Potato Flour: Effect of Drying Method and Variety on the Quality and Bioactivity.

Sweet potato ( (L.) Lam.) is a nutrient-dense crop rich in fibre, minerals, and antioxidant compounds, including carotenoids and phenolic compounds, such as anthocyanins.

Biotechnological 2-Phenylethanol Production: Recent Developments.

2-Phenylethanol (2-PE) is a key flavor compound with a rose-like scent, used in the cosmetics, perfume, home care and food industries. This aroma compound can be obtained naturally from various flowers, however chemical synthesis is the most used route to meet market demand. The increasing interest in natural products has led to the development of more environmentally friendly alternatives for 2-PE production through biotechnological approaches.

Symmetry Breaking in the Lowest-Lying Excited-State of CCl: Valence Shell Spectroscopy in the 5.0-10.8 eV Photon Energy Range.

We report absolute high-resolution vacuum ultraviolet (VUV) photoabsorption cross-sections of carbon tetrachloride (CCl) in the photon energy range 5.0-10.8 eV (248-115 nm).

Non-Thermal Treatment Mediated by Curcumin for Enhancing Food Product Quality.

Increasing antibiotic resistance is one of the world's greatest health problems, and biocide use in food disinfection, alongside other application fields, could increase antibiotic resistance. Effective and eco-friendly food decontamination treatment with minimal chemical intervention in food production is urgently needed. Synergistic antimicrobial interaction of photoactive compounds and blue-light-emitting diodes have recently been proven effective in agricultural and environmental applications.

Advancing Health and Sustainability: A Holistic Approach to Food Production and Dietary Habits.

Producing healthier food requires expertise in methods that yield significant benefits for human health, sustainability, economic growth, cultural heritage, and overall well-being. Investing in conscientious and sustainable food systems can improve individual and planetary quality of life by preventing diseases, delaying ageing, and enhancing well-being. While healthy eating habits begin at home, schools play a pivotal role in reinforcing them from an early age.

Evaluation of smartphone-based cough data in amyotrophic lateral sclerosis as a potential predictor of functional disability.

Objectives: Cough dysfunction is a feature of patients with amyotrophic lateral sclerosis (ALS). The cough sounds carry information about the respiratory system and bulbar involvement. Our goal was to explore the association between cough sound characteristics and the respiratory and bulbar functions in ALS.

Monitoring conformational changes in the human neurotransmitter transporter homologue LeuT with F-NMR spectroscopy.

Neurotransmitter:sodium symporters (NSS) reuptake neurotransmitter molecules from the synaptic space through Na-coupled transport. They are thought to work via the alternating access mechanism, exploring multiple configurations dictated by the binding of substrates and ions. Much of the current knowledge about these transporters has been derived from examining the structure of the Leucine Transporter (LeuT), a bacterial counterpart to human NSSs.

A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.

Study Question: Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility?

Summary Answer: Our findings revealed a significant association between SPGF and the gene and identified three novel genes (, , and ) along with 32 potentially pathogenic rare variants in 30 genes that contribute to this condition.

What Is Known Already: SPGF is a major cause of male infertility, often with an unknown aetiology. SPGF can be due to either multifactorial causes, including both common genetic variants in multiple genes and environmental factors, or highly damaging rare variants.

New insights in uranium bioremediation by cytochromes of the bacterium Geotalea uraniireducens.

The bacterium Geotalea uraniireducens, commonly found in uranium-contaminated environments, plays a key role in bioremediation strategies by converting the soluble hexavalent form of uranium (U(VI)) into less soluble forms (e.g., U(IV)).

A European aerosol phenomenology - 9: Light absorption properties of carbonaceous aerosol particles across surface Europe.

Carbonaceous aerosols (CA), composed of black carbon (BC) and organic matter (OM), significantly impact the climate. Light absorption properties of CA, particularly of BC and brown carbon (BrC), are crucial due to their contribution to global and regional warming. We present the absorption properties of BC (b) and BrC (b) inferred using Aethalometer data from 44 European sites covering different environments (traffic (TR), urban (UB), suburban (SUB), regional background (RB) and mountain (M)).

Uncovering layer by layer the risk of nanoplastics to the environment and human health.

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged as a persistent environmental contaminant with potential risk to both environment and human health. Nanoplastics might translocate across biological barriers and accumulate in vital organs, leading to inflammatory responses, oxidative stress, and genotoxicity, already reported in several organisms. Disruptions to cellular functions, hormonal balance, and immune responses were also linked to NPs exposure in assays.

Standards for Quality Improvement Registries on Abdominal Aortic Aneurysm Repair: A Delphi Consensus Report From VASCUNET and International Consortium of Vascular Registries.

Objective: Outcome registries in vascular surgery are increasingly used to drive quality improvement by vascular societies. The VASCUNET collaboration, within the European Society for Vascular Surgery (ESVS), and the International Consortium of Vascular Registries (ICVR) developed a set of variables for quality improvement registries on abdominal aortic aneurysm (AAA) repair as a registry standard.

Methods: Representatives from international vascular registries within VASCUNET, ICVR, and other nations with established registries were invited to provide the variables.

Occupational Stress and Sleep of Military Police Officers From Rio de Janeiro, Brazil.

Objective: Military Police officers of Rio de Janeiro's State have been considered the most lethal security forces in Brazil, corresponding to 52.35% of deaths in policing actions. The main aim of this study was to identify occupational stress among military police officers in Rio de Janeiro State and its relationship with the psychosocial environment, sleep quality, and daytime sleepiness.