12,118 results match your criteria: "NOVA Medical School|Faculdade de Ciencias Medicas NMS|FCM[Affiliation]"

Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro.

Bioengineering (Basel)

November 2024

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.

Article Synopsis
  • The study investigates how dextran solutions and corneal collagen crosslinking (CXL) affect the biomechanics of the cornea using Corvis ST technology, utilizing 40 porcine eyes as subjects.
  • Two concentrations of dextran (2% and 20%) were tested, revealing that higher dextran concentration altered corneal elasticity and stiffness, with significant changes observed after CXL treatment.
  • Results indicate that both dextran and CXL affect corneal biomechanical properties, suggesting that dextran concentration can influence CXL effectiveness, and the stiffness parameter SP-A1 could serve as a useful evaluation metric for CXL.
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Impact of eating difficulties and gastrointestinal problems on the nutritional status of children and adolescents with cerebral palsy.

Eur J Clin Nutr

November 2024

Instituto de Investigación en Ciencias de la Salud, Consejo Nacional de Investigación en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina.

Article Synopsis
  • The study focused on how dietary issues and gastrointestinal problems affect the nutrition of children and young adults (ages 2-19) with cerebral palsy (CP) in Córdoba, Argentina.
  • It used data from 105 individuals to analyze their nutritional status, finding that those who depend on caregivers for feeding and require changes in food consistency are significantly more likely to be undernourished.
  • The research concluded that conditions like dysphagia (difficulty swallowing) and constipation are related to poorer nutrition, emphasizing the need for tailored nutritional strategies for these children.
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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led the medical and scientific community to explore the pathogenesis and clinical manifestations of coronaviruses. In felines, a widespread coronavirus known as feline coronavirus (FCoV) can lead to feline infectious peritonitis (FIP), a highly fatal disease characterised by severe systemic inflammation. Diagnosing FCoV remains challenging due to the limited accuracy of the available methods.

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Background: Mpox is a viral zoonosis that has gained increased attention due to a global outbreak in 2022, significantly impacting men who have sex with men (MSM). Vaccination for this disease poses a public health challenge; because it carries a strong stigma, there may be greater hesitancy in vulnerable groups.

Objectives: This study aimed to determine the prevalence and factors associated with Mpox vaccine hesitancy among Brazilian MSM.

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Article Synopsis
  • The LANDMARK trial compared the balloon-expandable Myval transcatheter heart valve (THV) series to the SAPIEN and Evolut THV series in 768 patients to evaluate safety and effectiveness.
  • Results showed that Myval achieved non-inferiority to SAPIEN (24.7% vs 24.1%) and Evolut (24.7% vs 30.0%) regarding a primary composite safety endpoint.
  • Additionally, while Myval had better pressure gradient metrics compared to SAPIEN, Evolut showed slightly higher rates of prosthetic valve regurgitation compared to Myval but no significant difference between Myval and SAPIEN.
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Major sight-threatening eye disorders and mental disorders.

Acta Ophthalmol

November 2024

School of Public Health; The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.

Article Synopsis
  • The study aimed to explore the link between serious eye disorders and mental health issues, focusing on prevalence and influencing factors.
  • A systematic review included 67 studies and found that diabetic retinopathy and depression had a 30% co-occurrence rate, while diabetic retinopathy and anxiety had a 29% rate.
  • Significant associations were identified between eye disorders like glaucoma and mental health conditions such as depression, anxiety, and schizophrenia, highlighting the importance of income as a factor in these comorbidities.
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Article Synopsis
  • COVID-19 significantly transformed continuing professional development (CPD) in Canadian Psychiatry, leading to a rapid shift towards virtual delivery methods.
  • A survey of CPD directors indicated increased attendance and reduced costs with virtual CPD, alongside a desire to maintain these methods in the future.
  • The continued use of hybrid CPD formats will require additional resources and collaboration among directors to share knowledge and address challenges.
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Background: Providing physical activity counselling and prescribing exercise increases patients' activity and cardiorespiratory fitness, but healthcare providers experience challenges in promoting activity to patients. Implementing educational intervention during medical training may be an effective strategy to promote physical activity and exercise counselling/prescriptions. The purpose of this review was to evaluate the impact of educational interventions on medical students' physical activity counselling and exercise prescription perceptions and practices.

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Mitochondrial dysfunction and associated inflammatory signaling are pivotal in both aging and in Alzheimer's disease (AD). Studies have also shown that hypothalamic function is affected in AD. The hypothalamus may be a target for AD drugs given that mitochondrial alterations are observed in the hypothalamus.

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Patients with associated spine or other major joint pain have equivalent outcomes to patients with isolated hip pain after hip arthroscopy.

J ISAKOS

November 2024

Division of Orthopaedic Surgery, Nova Scotia Health, Halifax, Nova Scotia, Canada; Department of Orthopaedic Surgery, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Objectives: This study aims to evaluate the outcomes of patients following surgery diagnosed with femoroacetabular impingement syndrome (FAIS) who also experience low back and other joint pain compared to those with isolated hip pain.

Methods: This is a retrospective cohort study of patients diagnosed with FAIS, with or without other joint pain, treated with hip arthroscopy from 2016 to 2020. Excluded cases were patients who had significant arthritis, irreparable labral tear requiring reconstruction, or were lost follow-up.

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Falls and hip fractures are a major health concern among older adults in long term care (LTC) with almost 50% of residents experiencing a fall annually. Hip fractures are one of the most important and frequent fall-related injuries in LTC. There is moderate to strong certainty evidence that multifactorial interventions may reduce the risk of falls and fractures; however, there is little evidence to support its implementation.

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Based on its anti-inflammatory and antioxidant properties, (DC) Stapf is commonly used in traditional and modern medicine to cure different diseases. The present study investigates the potential of organic extract as an anti-obesity drug in a HCHFD (high-carbohydrate, high-fat diet) model for obese rats. Its negative hypolipidemic effect has been confirmed through biochemical and histological methods.

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Article Synopsis
  • Violence against health professionals is a significant issue in the Alentejo region of Portugal, with 40% of surveyed health workers reporting incidents, particularly among nurses (80%).
  • Despite awareness of reporting channels, only 52% actually report these incidents, highlighting an under-reporting problem.
  • The consequences of violence include mental health issues for workers and a decline in patient care quality, with recommendations for improved security and training to address this violence.
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Article Synopsis
  • Individualized nursing care focuses on tailored assessments and interventions while considering patients' preferences and contexts for better health outcomes.
  • A study involving 122 registered nurses in various medical services in Portugal assessed their perceptions of individualized care using the Individualized Care Scale, revealing high value for its importance but challenges in implementation.
  • Key findings highlighted a need for improvement in addressing personal aspects of patient care, notably family involvement and daily habits, suggesting areas for targeted training and policy development.
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Article Synopsis
  • - Atypical hemolytic uremic syndrome (aHUS) is a complex disorder caused by issues with the complement system, often leading to serious blood and kidney problems.
  • - A case study of a 38-year-old woman shows that aHUS can develop after gastroenteritis even without the common genetic markers or abnormal complement levels.
  • - This situation underlines the difficulties in diagnosing and managing aHUS when typical signs are missing, pointing to the need for personalized treatment strategies.
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Article Synopsis
  • Meningococcal serogroup B (MenB) vaccination with the 4CMenB vaccine was tested for its effectiveness and safety among 3,651 healthy participants aged 10 to 25, using different dosing schedules (0-2, 0-6, and 0-2-6 months).
  • The study measured the immune response through two methods: a test-based approach showing high immune breadth (over 78%) and a responder-based approach indicating a significant percentage of participants achieved strong responses (up to 93.4% for the 0-2-6 schedule).
  • The results showed no major differences in effectiveness across the dosing schedules, confirming that the simpler 2-dose regimen (0-2)
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Predictive Factors Driving Positive Awake Test in Carotid Endarterectomy Using Machine Learning.

Ann Vasc Surg

November 2024

CINTESIS@RISE, RISE-Health, Unit of Research, Porto, Portugal; Department of Biomedicine - Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Background: Positive neurologic awake testing during the carotid cross-clamping may be present in around 8% of patients undergoing carotid endarterectomy (CEA). The present work aimed to assess the accuracy of an artificial intelligence (AI)-powered risk calculator in predicting intraoperative neurologic deficits (INDs).

Methods: Data was collected from carotid interventions performed between January 2012 and January 2023 under regional anesthesia.

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Article Synopsis
  • In a study on children with Phenylketonuria (PKU), casein glycomacropeptide (GMP) was compared to phenylalanine-free amino acids (AA) as a protein substitute, focusing on digestion and overall health effects.
  • Results showed that GMP significantly improved gastrointestinal symptoms like stomach pain and bloating, although it did not have a major impact on other health markers like renal function or oxidative stress.
  • However, GMP's higher phenylalanine content poses challenges for use as a sole protein source in PKU kids due to their low tolerance for phenylalanine.
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D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care.

Crit Care

November 2024

Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Level 4, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

Article Synopsis
  • The D-PRISM study investigated global practices for diagnosing and treating pneumonia in ICU settings, focusing on community-acquired, hospital-acquired, and ventilator-associated pneumonia across different countries.
  • A survey gathered responses from 1,296 ICU clinicians across 72 countries, revealing varied diagnostic processes and a lack of standardized microbiological testing, particularly in lower-income regions.
  • Findings indicated that the typical antibiotic treatment duration was 5-7 days, with shorter durations linked to effective antimicrobial stewardship programs in higher-income countries.
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Postoperative oliguria after intermediate and high-risk surgeries in critical care, A cohort analysis.

J Crit Care

February 2025

General ICU, Hospital Vila Nova Star - Rede D'OR, São Luiz, Brazil; Oncological ICU, Hospital São Luiz Itaim - Rede D'OR, São Luiz, Brazil; Nephrology department, ABC medical school, Av. Lauro Gomes, 2000 - Santo André - SP, 09060-870, Brazil; Research and teaching institute - Rede D'OR, São Paulo, Brazil. Electronic address:

Article Synopsis
  • Oliguria, a condition characterized by decreased urine output, may be misinterpreted as acute kidney injury (AKI) in patients post-surgery, despite being a potential adaptive response during surgery.
  • A study analyzing 1,476 patients revealed that 34.4% exhibited oliguria within the first 24 hours after surgery, with certain factors like vasopressor use and non-elective procedures linked to increased risk.
  • Although oliguria was associated with a higher rate of AKI development compared to non-oliguric patients, 87.6% of oliguric patients did not show kidney dysfunction based on serum creatinine levels, questioning the accuracy of oliguria as an indicator for AKI.
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Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.

JAMA Netw Open

November 2024

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.

Article Synopsis
  • The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
  • Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
  • Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
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Background And Objectives: Prospective data on presentation and outcomes of colorectal cancer (CRC) in Nigeria are limited; however, emergency presentation with advanced disease is thought common.

Methods: Consecutive CRC patients presenting at six sites over 6 years were included. Risk factors for emergency presentation were evaluated using logistic regression methods.

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Violence against healthcare professionals: perspective of local focal points in the south of Portugal.

BMC Health Serv Res

November 2024

CHRC - Comprehensive Health Research Centre, University of Évora, NOVA Medical School, Lisbon, 1150-082, Portugal.

Background: Violence against health professionals is a growing problem that affects the quality of care provided and the well-being of workers. In the Alentejo region (Southern Portugal), the Regional Health Administration has been developing strategies to prevent and combat this phenomenon, namely, through the implementation of the Action Plan for the Prevention of Violence in the Health Sector. Violence in the health sector includes all situations in which a worker in the Ministry of Health's health institutions is exposed to any type of violence related to their work, putting their safety, well-being or health at risk, or that of others.

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Article Synopsis
  • - The study investigates the relationship between the Geographic Tongue Area and Severity Index (GTASI) scores and the histopathological features of geographic tongue lesions, an oral condition with unclear causes.
  • - Conducted with 40 participants, the results show that 60% had mild cases, with common histological traits observed, such as parakeratosis and basal layer hyperplasia, regardless of severity levels.
  • - Findings indicate that while mild cases exhibit low inflammatory response, more severe cases show distinct histopathological features, suggesting a strong link between the clinical severity of geographic tongue and its histological characteristics.
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