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1,435 results match your criteria: "NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)[Affiliation]"
J Affect Disord
December 2024
Dementia Services Development Centre (DSDC) Wales, School of Health Sciences, Bangor University, United Kingdom. Electronic address:
Background: Sense of coherence (SOC) is a disposition to perceive things as comprehensible, manageable and meaningful. Lower SOC is associated with subjective burden and psychological morbidity in family caregivers, including in dementia. However, the evidence-base mainly comprises small-scale or cross-sectional studies.
View Article and Find Full Text PDFRedox Biol
December 2024
Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE).
View Article and Find Full Text PDFBMC Med Educ
December 2024
Comprehensive Health Research Centre (CHRC), NOVA Medical School, NOVA University, Lisbon, Portugal.
Background: Clinical reasoning significantly impacts physicians' performance and patient care quality. Research into learning transfer within clinical reasoning education, especially in managing multimorbidity in Family Medicine, is crucial. This study evaluates the impact of concept maps (CMs) on promoting clinical reasoning skills among undergraduate students, compared to traditional teaching methods (TM).
View Article and Find Full Text PDFPLoS Biol
December 2024
Champalimaud Research & Clinical Centre, Champalimaud Foundation, Av. de Brasília, Doca de Pedrouços, Lisboa, Portugal.
Postingestive nutrient stimulation conditions food preferences through striatal dopamine and may be associated with blunted brain responses in obesity. In a cross-sectional study, we tested flavor-nutrient conditioning (FNC) with maltodextrin-enriched yogurt, with maltodextrin previously optimized for concentration and dextrose equivalents (n = 57), and to mask texture cues (n = 102). After conditioning, healthy volunteers (n = 52) increased preference for maltodextrin-paired (+102 kcal, CS+), relative to control (+1.
View Article and Find Full Text PDFEur J Clin Invest
December 2024
iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal.
Eur J Clin Invest
December 2024
iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal.
Background: Type 2 diabetes (T2DM) and obesity are characterized by altered insulin metabolism and action. Reduced hepatic insulin clearance is increasingly recognized as a key contributor to hyperinsulinemia and insulin resistance. CEACAM1 promotes hepatic insulin clearance, and its loss in hepatocytes is associated with reduced insulin clearance in mice and men.
View Article and Find Full Text PDFActa Trop
December 2024
Universidade Federal de Pelotas - UFPel, Departamento de Microbiologia e Parasitologia, Laboratório de Ecologia de Parasitos e Vetores (LEPAV). Pelotas, RS, Brasil. Electronic address:
Molossus molossus is a widely distributed neotropical bat species in the Americas, often found in urban areas. This study evaluated climate change effects on the potential geographic distribution of M. molossus, a natural host of zoonotic pathogens such as Orthohantavirus, in the Neotropical region.
View Article and Find Full Text PDFJ Neurol
December 2024
Faculdade de Ciências Médicas da UNICAMP, Departamento de Neurologia da FCM/UNICAMP, Department of Neurology, Universidade Estadual de Campinas, University of Campinas, Cidade Universitária s/n Caixa Postal, 6111 Barão Geraldo, 13083970, Campinas, SP, Brasil.
Background: Spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders characterized by progressive ataxia. Although previous studies have focused on cerebral and cerebellar damage, spinal cord involvement in SCAs remains underexplored.
Objectives: This study aims to characterize spinal cord abnormalities in SCA2, SCA3, and SCA6 and to identify its phenotypic correlates.
Graefes Arch Clin Exp Ophthalmol
December 2024
Instituto de Microcirugía Ocular (IMO) Barcelona Grupo Miranza, Barcelona, Spain.
J Pediatr (Rio J)
December 2024
Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Departamento de Pediatria, Divisão de Endocrinologia Pediátrica, Campinas, SP, Brazil. Electronic address:
Objective: It was to develop smoothed height and weight percentiles for boys and girls with IDs between 7 and 17 years old.
Methods: The sample consisted of 1,047 young people (645 boys and 402 girls; 7-17 years old) with ID. A total of 4,059 measurements (height: n = 2,041; weight: n = 2,018) were retrospectively obtained from the period between 2013 and 2018.
Rev Port Cardiol
December 2024
Pediatric Cardiology Department, Hospital de Santa Marta, Unidade Local de Saúde São José EPE, 1150-293 Lisbon, Portugal; Clínica Universitária de Cardiologia Pediátrica, Centro Clínico Académico de Lisboa, 1150-293 Lisbon, Portugal; Comprehensive Health Research Center, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal. Electronic address:
Eur J Vasc Endovasc Surg
December 2024
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Sala, Sweden.
Objective: Outcome registries in vascular surgery are increasingly used to drive quality improvement by vascular societies. The VASCUNET collaboration, within the European Society for Vascular Surgery (ESVS), and the International Consortium of Vascular Registries (ICVR) developed a set of variables for quality improvement registries on abdominal aortic aneurysm (AAA) repair as a registry standard.
Methods: Representatives from international vascular registries within VASCUNET, ICVR, and other nations with established registries were invited to provide the variables.
Eur Neuropsychopharmacol
December 2024
Champalimaud Research & Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.
Radiol Bras
November 2024
Department of Imaging, A.C.Camargo Cancer Center, São Paulo, SP, Brazil.
Hematol Transfus Cell Ther
November 2024
Faculdade de Ciências Médicas, Universidade de Campinas (FCM Unicamp), Campinas, SP, Brazil; Hemocentro, Universidade de Campinas (FCM Unicamp), Campinas, SP, Brazil. Electronic address:
Braz J Infect Dis
November 2024
Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Laboratório de Pesquisa Aplicada Dermatologia e Infecção por Bartonella, Campinas, SP, Brazil.
Medicina (Kaunas)
November 2024
Unidade Local de Saúde São José EPE, Pediatric Cardiology Department, Hospital de Santa Marta, Reference Center for Congenital Heart Diseases, Member of the European Reference Network for Rare, Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), 1150-199 Lisbon, Portugal.
: Despite advances in the surgical management of patients with Fontan circulation, their exercise capacity and quality of life remain significantly impaired. Exercise-based cardiac rehabilitation (CR) offers promising improvements in these areas, but the implementation and adherence to these programmes are often inconsistent. This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients.
View Article and Find Full Text PDFNat Commun
November 2024
Laboratory of Genetics in Ophthalmology (LGO), INSERM UMR1163, Institute of Genetic Diseases, Imagine and Paris Cité University, Paris, France.
Here we conduct a study involving 12 individuals with retinal dystrophy, neurological impairment, and skeletal abnormalities, with special focus on GPATCH11, a lesser-known G-patch domain-containing protein, regulator of RNA metabolism. To elucidate its role, we study fibroblasts from unaffected individuals and patients carrying the recurring c.328+1 G > T mutation, which specifically removes the main part of the G-patch domain while preserving the other domains.
View Article and Find Full Text PDFNPJ Parkinsons Dis
November 2024
Champalimaud Research and Clinical Centre, Champalimaud Foundation, Av. Brasília, 1400-038, Lisboa, Portugal.
Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson's Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients.
View Article and Find Full Text PDFComput Biol Med
January 2025
ISEL - Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Rua Conselheiro Emídio Navarro 1, 1959-007, Lisbon, Portugal; IBB-Institute for Bioengineering and Biosciences, The Associate Laboratory Institute for Health and Bioeconomy (i4HB), Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisbon, Portugal. Electronic address:
Serum metabolome analysis is essential for identifying disease biomarkers and predicting patient outcomes in precision medicine. Thus, this study aims to compare Ultra-High Performance Liquid Chromatography-High-Resolution Mass Spectrometry (UHPLC-HRMS) with Fourier Transform Infrared (FTIR) spectroscopy in acquiring the serum metabolome of critically ill patients, associated with invasive mechanical ventilation (IMV), and predicting death. Three groups of 8 patients were considered.
View Article and Find Full Text PDFInt J Pharm
January 2025
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, Lisboa 1649-003, Portugal; Instituto de Biofísica e Engenharia Biomédica (IBEB), Faculdade de Ciências, Universidade de Lisboa, Campo Grande 1749-016, Lisboa, Portugal. Electronic address:
Melanoma is the most aggressive type of skin cancer and recently approved drugs are often associated with resistance and significant adverse effects. Therefore, the design of more effective and safe options remains imperative. Photothermal therapy (PTT) using gold nanoparticles (AuNPs) presents a promising and innovative approach.
View Article and Find Full Text PDFGeroscience
November 2024
Intensive Care Department, ULSSJ - Unidade Local de Saúde São José, Rua José António Serrano, 1150-199, Lisbon, Portugal.
Identifying high-risk patients, particularly in intensive care units (ICUs), enhances treatment and reduces severe outcomes. Since the pandemic, numerous studies have examined COVID-19 patient profiles and factors linked to increased mortality. Despite six pandemic waves, to the best of our knowledge, there is no extensive comparative analysis of patients' characteristics across these waves in Portugal.
View Article and Find Full Text PDFFront Med (Lausanne)
October 2024
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
BMC Health Serv Res
November 2024
Comprehensive Health Research Center (CHRC), National School of Public Health, NOVA University of Lisbon, Lisbon, Portugal.
Background: To address the societal burden of low back pain (LBP), several health systems have adopted Models of Care (MoCs). These evidence-informed models aim for consistent care and outcomes. However, real-world applications vary, with each setting presenting unique challenges and nuances in the primary healthcare landscape.
View Article and Find Full Text PDF