3 results match your criteria: "NO. 905 Hospital of PLA Navy affiliated to Naval Medical University[Affiliation]"
Heterozygous Spink1 c.194+2T>C mutation promotes chronic pancreatitis after acute attack in mice.
Pancreatology
August 2024
Department of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China; Shanghai Institute of Pancreatic Diseases, Shanghai, 200433, China. Electronic address:
Background & Aims: Mutations in genes, including serine protease inhibitor Kazal-type 1 (SPINK1), influence disease progression following sentinel acute pancreatitis event (SAPE) attacks. SPINK1 c.194+2T > C intron mutation is one of the main mutants of SPINK1，which leads to the impairment of SPINK1 function by causing skipping of exon 3.
View Article and Find Full Text PDFPancreas-directed AAV8 gene therapy safely and effectively protects against pancreatitis in mice.
Gut
June 2024
Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China
Article Synopsis
- Researchers are studying a way to help people with chronic pancreatitis (CP), which currently has no cure.
- They used a special virus (AAV8) to deliver a treatment directly to the pancreas in mice, which helped lessen symptoms and speed up recovery from the disease.
- The results showed that this treatment was safe and worked well, making it a hopeful option for stopping or treating CP in the future.
Objectives: This study aims to assess the volunteer motivation and stress load of patient volunteers in the Fangcang shelter hospitals (FSHs), examine their associations, and explore the potential influence factors of volunteer motivation.
Design: Cross-sectional online survey conducted from 21 April to 20 May 2022.
Setting: Questionnaires were collected from patient volunteers selected by random cluster sampling in the FSHs in Shanghai, China.