1 results match your criteria: "NIH Animal Center Poolesville[Affiliation]"
Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques.
Alcohol Clin Exp Res
July 2008
Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center Poolesville, Maryland 20837-0529, USA.
Background: Acute and chronic tolerance, as well as locomotor sensitization, have been linked to ethanol intake. This study examined the change in response between 2 acutely administered doses of ethanol in adolescent rhesus macaques, with the objective of investigating rapid tolerance and locomotor sensitization to the behavioral effects of ethanol, and whether these phenomena are related to voluntary ethanol consumption in nonhuman primates.
Methods: Rhesus macaques (n = 109, 42 males, 67 females) were administered 2 sequential intravenous doses of ethanol (2.