1 results match your criteria: "NIH 10 Center Dr. Bld 10-CRC[Affiliation]"
Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes.
Diabetologia
March 2015
National Institute of Diabetes and Digestive and Kidney Diseases, NIH 10 Center Dr. Bld 10-CRC, RM 5-5740, MSC 1612, Bethesda, MD, 20892-1612, USA,
Aims/hypothesis: The role of increased gluconeogenesis as an important contributor to fasting hyperglycaemia at diabetes onset is not known. We evaluated the contribution of gluconeogenesis and glycogenolysis to fasting hyperglycaemia in newly diagnosed youths with type 2 diabetes following an overnight fast.
Methods: Basal rates (μmol kg(FFM) (-1) min(-1)) of gluconeogenesis ((2)H2O), glycogenolysis and glycerol production ([(2)H5] glycerol) were measured in 18 adolescents (nine treatment naive diabetic and nine normal-glucose-tolerant obese adolescents).