55 results match your criteria: "NICU "V. Buzzi" Children's Hospital[Affiliation]"

Reference Ranges for Arterial Oxygen Saturation, Heart Rate, and Cerebral Oxygen Saturation during Immediate Postnatal Transition in Neonates Born Extremely or Very Preterm.

J Pediatr

October 2024

Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. Electronic address:

Article Synopsis
  • The study aimed to create percentile charts for arterial oxygen saturation (SpO), heart rate (HR), and cerebral oxygen saturation (crSO) in very or extremely preterm neonates during their first 15 minutes after birth.
  • It analyzed data from the COSGOD III trial, focusing on neonates with favorable outcomes, excluding those with early inflammatory issues, and utilized various methods for measuring the oxygen and heart metrics.
  • The findings revealed specific percentiles for SpO, HR, and crSO at 2, 5, 10, and 15 minutes post-birth, providing a new reference that could aid in better managing oxygen levels during the critical stabilization period after delivery.
View Article and Find Full Text PDF

Background: The prognostic relevance of fetal/early postnatal magnetic resonance (MR) imaging (MRI) isolated "minor" lesions in congenital cytomegalovirus (CMV) infection is still unclear, because of the heterogeneity of previously reported case series. The aim of this study was to report the imaging and long-term clinical follow-up data on a relatively large cohort of infected fetuses.

Methods: Among 140 CMV-infected fetuses from a single-center 12-year-long fetal MRI database, cases that showed isolated "minor" lesions at MRI, mainly represented by polar temporal lesions, were selected.

View Article and Find Full Text PDF

Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus.

View Article and Find Full Text PDF

Cultivation and sequencing-free protocol for detection and typing.

iScience

April 2024

Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center "Romeo and Enrica Invernizzi", University of Milan, 20157 Milan, Italy.

Article Synopsis
  • The study focuses on an opportunistic pathogen that thrives in harsh environments and often leads to outbreaks in neonatal intensive care units (NICUs), primarily caused by a specific clone, referred to as the "Infectious clone."
  • It introduces a new method called hypervariable-locus melting typing (HLMT) that allows rapid detection and typing of this pathogen without the need for cultivation, achieving high accuracy with 97% specificity and 96% sensitivity compared to traditional whole genome sequencing (WGS).
  • The HLMT protocol is advantageous for large-scale environmental and clinical screenings, offering cost and time efficiency that is particularly beneficial in low- to middle-income countries.
View Article and Find Full Text PDF
Article Synopsis
  • Half of very preterm infants with respiratory distress syndrome fail treatment with nasal continuous positive airway pressure (NCPAP) and need mechanical ventilation (MV).
  • This study aimed to compare nasal intermittent positive pressure ventilation (NIPPV) and NCPAP during less invasive surfactant treatment (LISA) for improving respiratory outcomes.
  • Results showed no significant difference in respiratory outcomes between NIPPV and NCPAP, suggesting that both methods are equally effective and safe during LISA.
View Article and Find Full Text PDF

Background: Proper umbilical cord stump care during the first days of life (both in hospital and at home) should not be overlooked to prevent possible complications (e.g., purulent discharge, granulomas, or periumbilical erythema or omphalitis).

View Article and Find Full Text PDF

Background: The recent guidelines suggest the use of genome-wide analyses, such as whole exome sequencing (WES), at the beginning of the diagnostic approach for cases with suspected genetic conditions. However, in many realities it still provides for the execution of a multi-step pathway, thus requiring several genetic tests to end the so-called 'diagnostic odyssey'.

Methods: We reported the results of GENE Project (Genomic analysis Evaluation NEtwork): a multicentre prospective cohort study on 125 paediatric outpatients with a suspected genetic disease in which we performed first-tier trio-WES, including exome-based copy number variation analysis, in parallel to a 'traditional approach' of two/three sequential genetic tests.

View Article and Find Full Text PDF

Pressure and tidal volume delivery in extremely preterm infants at birth using different t-piece resuscitation devices.

Early Hum Dev

August 2023

Newborn Services, John Radcliffe Hospital, Oxford University Hospital, Oxford, UK; Department of Paediatrics, Division of Medical Sciences, University of Oxford, Oxford, UK. Electronic address:

Infants <28 weeks' gestation in need of inflations at birth were recorded with Respiratory Function Monitor. Two devices were used for resuscitation. Peak Inspiratory Pressure spikes were visible in all inflations with GE Panda and in none with Neo-Puff.

View Article and Find Full Text PDF

Objective: To investigate whether monitoring of cerebral tissue oxygen saturation using near infrared spectroscopy in addition to routine monitoring combined with defined treatment guidelines during immediate transition and resuscitation increases survival without cerebral injury of premature infants compared with standard care alone.

Design: Multicentre, multinational, randomised controlled phase 3 trial.

Setting: 11 tertiary neonatal intensive care units in six countries in Europe and in Canada.

View Article and Find Full Text PDF

Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.

Lancet

February 2023

Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK; St George's University Hospitals NHS Foundation Trust, London, UK. Electronic address:

Background: In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has undergone genetic mutations. We aimed to examine the effects on maternal and perinatal outcomes of COVID-19 during pregnancy, and evaluate vaccine effectiveness, when omicron (B.

View Article and Find Full Text PDF

Aim: To verify the added value of respiratory function monitor (RFM) to assess ventilation and the heart rate (HR) changes during stabilization of preterm infants.

Methods: Preterm infants <32 weeks' gestation, bradycardic at birth and in need for positive pressure ventilation (PPV) were included. The first 15 min of stabilization was monitored with RFM.

View Article and Find Full Text PDF

Objective: To investigate the relationship between the Neonatal Assessment Manual scorE (NAME) and newborns' clinical condition on a large number of infants. The NAME model was developed as an instrument to assess the infant's general conditions, especially in NICUs, by evaluating how the infant's body responds to an external stressor such as static touch. Previous studies, employing experienced assessors, showed good validity indices as well as high inter-rater reliability.

View Article and Find Full Text PDF

Current neonatal early-onset sepsis (EOS) guidelines lack consensus. Recent studies suggest three different options for EOS risk assessment among infants born ≥35 wks gestational age (GA), leading to different behaviors in the sepsis workup and antibiotic administration. A broad disparity in clinical practice is found in Neonatal Units, with a large number of non-infected newborns evaluated and treated for EOS.

View Article and Find Full Text PDF

Despite clinical improvements in neonatal intensive care units (NICUs), prematurity keeps causing several comorbidities. To enhance the management of such conditions, in previous studies we devised the Neonatal Assessment Manual scorE (NAME) model, a structured touch-based assessment that aims to evaluate how newborns respond to gentle touch-based stimuli. The present study aimed to begin assessing the NAME interrater reliability and specific agreements.

View Article and Find Full Text PDF

Background: Neonatal hypoglycemia is a common disorder especially in at-risk infants and it can be associated with poor long-term neurological outcomes. Several therapeutic interventions are suggested, from the implementation of breastfeeding to the glucose intravenous administration. Oral dextrose gel massaged into the infant's inner cheek is a recent treatment option of asymptomatic hypoglycemia, after which oral feeding is encouraged.

View Article and Find Full Text PDF

The COVID-19 pandemic is a collective trauma that is threatening citizens' mental health resulting in increased emotional stress, reduced social support, and heightened risk for affective symptoms. The present study aimed to investigate the effects of antenatal pandemic-related emotional stress and perceived social support on the symptoms of depression and anxiety of mothers who were pregnant during the initial COVID-19 outbreak in northern Italy. A sample of 281 mothers was enrolled at eight maternity units in the first hotspot region of the COVID-19 outbreak in northern Italy.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate if using a respiratory function monitor (RFM) during positive pressure ventilation (PPV) improves the percentage of inflations with the desired tidal volume in extremely preterm infants.
  • Conducted as a clinical trial in neonatal intensive care units across 6 countries, infants were randomly assigned to either have the RFM visible or not while receiving PPV, with a focus on comparing the percentage of inflations within the target range of 4-8 mL/kg.
  • Results showed no significant difference in the percentage of correct inflations between the two groups; however, the group with visible RFM had a lower incidence of serious brain conditions, indicating possible benefits despite the primary outcome not being met.
View Article and Find Full Text PDF

Impact of bradycardia and hypoxemia on oxygenation in preterm infants requiring respiratory support at birth.

Resuscitation

July 2021

Division of Neonatology, Medical University of Graz, Auenbruggerplatz 34/2, 8036 Graz, Austria; Research Unit of Cerebral Development and Oximetry, Medical University of Graz, Auenbruggerplatz 34/2, 8036 Graz, Austria. Electronic address:

Aim Of The Study: Analysis of the impact of bradycardia and hypoxemia on the course of cerebral and peripheral oxygenation parameters in preterm infants in need for respiratory support during foetal-to-neonatal transition.

Methods: The first 15 min after birth of 150 preterm neonates in need for respiratory support born at the Division of Neonatology, Graz (Austria) were analyzed. Infants were divided into different groups according to duration of bradycardia exposure (no Bradycardia, brief bradycardia <2 min, and prolonged bradycardia ≥2 min) and to systemic oxygen saturation (SpO) value at 5 min of life (<80% or ≥80%).

View Article and Find Full Text PDF

Infections represent a serious health problem in neonates. Invasive infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses.

View Article and Find Full Text PDF

Consensus protocol for EEG and amplitude-integrated EEG assessment and monitoring in neonates.

Clin Neurophysiol

April 2021

Child Neuropsychiatric Unit, Neuroscience Section, Department of Medicine and Surgery, University of Parma, Italy.

The aim of this work is to establish inclusive guidelines on electroencephalography (EEG) applicable to all neonatal intensive care units (NICUs). Guidelines on ideal EEG monitoring for neonates are available, but there are significant barriers to their implementation in many centres around the world. These include barriers due to limited resources regarding the availability of equipment and technical and interpretive round-the-clock personnel.

View Article and Find Full Text PDF

The neonatal assessment manual score (NAME) for improving the clinical management of infants: a perspective validity study.

Ital J Pediatr

March 2021

RAISE lab, Foundation COME Collaboration, Corso Europa 29 - 66054 Vasto (Italy), Pescara, Italy.

Background And Objectives: The Neonatal Assessment Manual scorE (NAME) was developed to assist in the clinical management of infants in the neonatal ward by assessing their body's compliance and homogeneity. The present study begins its validation process.

Methods: An expert panel of neonatal intensive care unit (NICU) professionals investigated the NAME face and content validity.

View Article and Find Full Text PDF

Background: In preterm infants, InSurE (Intubation-Surfactant-Extubation) and LISA (less invasive surfactant administration) techniques allow for exogenous surfactant administration while reducing lung injury associated with mechanical ventilation. We compared the acute pulmonary response and lung deposition of surfactant by LISA and InSurE in surfactant-depleted adult rabbits.

Methods: Twenty-six spontaneously breathing surfactant-depleted adult rabbits (6-7 weeks old) with moderate RDS and managed with nasal continuous positive airway pressure were randomized to 3 groups: (1) 200 mg/kg of surfactant by InSurE; (2) 200 mg/kg of surfactant by LISA; (3) no surfactant treatment (Control).

View Article and Find Full Text PDF

Background: Although short binasal prongs (SBP) are the most common interface for noninvasive ventilation, the "double-inspiratory loop cannulas" (DILC) have recently been introduced into many neonatal intensive care units. DILC show advantages over SBP, including reduced nasal trauma and increased comfort. However, their higher intrinsic resistance may compromise ventilation.

View Article and Find Full Text PDF

Neonatal intensive care units (NICUs) greatly expand the use of technology. There is a need to accurately diagnose discomfort, pain, and complications, such as sepsis, mainly before they occur. While specific treatments are possible, they are often time-consuming, invasive, or painful, with detrimental effects for the development of the infant.

View Article and Find Full Text PDF

Northern Italy has been the first European area affected by the COVID-19 pandemic and related social restrictive measures. We sought to evaluate the impact of the COVID-19 outbreak on PICU admissions in Northern Italy, using data from the Italian Network of Pediatric Intensive Care Units Registry. We included all patients admitted to 4 PICUs from 8-weeks-before to 8-weeks-after February 24, 2020, and those admitted in the same period in 2019.

View Article and Find Full Text PDF