6 results match your criteria: "NIA-Layton Aging and Alzheimer's Disease Research Center[Affiliation]"
Depressive symptoms in older adult couples: Associations with dyadic physical health, social engagement, and close friends.
Front Psychiatry
September 2022
William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, United States.
Objective: The objective of this study was to examine associations between level of depressive symptoms in older adult spouse/partner couples and their physical health and social factors (social activity and number of close friends).
Methods: Using data from 116 community-dwelling couples (age 76.2 ± 8.
Venous Collagenosis as Pathogenesis of White Matter Hyperintensity.
Ann Neurol
December 2022
NIA-Layton Aging and Alzheimer's Disease Research Center, OHSU, Portland, Oregon.
Objective: Periventricular white matter hyperintensities (pvWMHs) are commonly observed on MRI in older individuals and are associated with cognitive and motor decline. The etiology of pvWMH remains unknown. Venous collagenosis has been implicated, which may also interfere with perivascular fluid flow leading to dilation of perivascular spaces (PVS).
View Article and Find Full Text PDFNutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.
Lancet Healthy Longev
July 2022
Department of Medicine (H N Yassine MD) and Department of Neurology (H N Yassine, Prof L S Schneider MD MS), Department of Psychiatry and Neuroscience (Prof L S Schneider), and Department of Gerontology (Prof L S Schneider), Keck School of Medicine and Department of Medicine (S Khosravian BA), University of Southern California, Los Angeles, CA, USA; Bordeaux population health U1219, National Institute of Health and Medical Research (INSERM)-University of Bordeaux, Bordeaux, France (C Samieri PhD); Division of Psychiatry, University College London, London, UK (G Livingston MD); Camden and Islington NHS Foundation Trust, London, UK (G Livingston); Channing Division of Network Medicine, Brigham and Women's Hospital, Boston MA, USA (K Glass PhD); Department of Medicine, Harvard Medical School (K Glass) and Department of Biostatistics, Harvard Chan School of Public Health (K Glass), Harvard University, Boston MA, USA; Rush Alzheimer's Disease Center (M Wagner PhD, F Grodstein ScD), Departments of Clinical Nutrition and Preventive Medicine (C Tangney PhD), Rush Center for Microbiome and Chronobiology Research (R M Voigt PhD), Department of Internal Medicine (R M Voigt), and Department of Anatomy and Cell Biology (R M Voigt), Rush University Medical Center (M Wagner) and Department of Neurological Sciences (M Wagner), Rush Medical College, Rush University, Chicago IL, USA; Department of Psychiatry and Behavioral Sciences, Duke University, Durham NC, USA (B L Plassman PhD); Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands (M A Ikram MD PhD); Department of Neurology and Department of Epidemiology, Taub Institute, Sergievsky Center, Columbia University Irving Medical Center (Y Gu MD PhD), and Department of Neurology (N Scarmeas MD), Colombia University, New York, NY, USA; University of North Texas Health Science Center, University of North Texas, Fort Worth, Texas TX, USA (S O'Bryant PhD); Norwich Medical School (A M Minihane PhD) and Norwich Institute of Healthy Ageing (A M Minihane), University of East Anglia, Norwich, UK; Department of Internal Medicine-Geriatrics, Wake Forest University School of Medicine, Wake Forest University, Wake Forest, NC, USA (S Craft PhD); Geriatric Research Education and Clinical Center, Minneapolis VA Health Care System, Minneapolis, MN, USA (H A Fink MD MPH); Biostatistics School of Public Health, University of Alabama at Birmingham, Birmingham AL, USA (S Judd PhD MPH); Aging Research team, Centre for Epidemiology and Research in Population Health, INSERM (S Andrieu MD PhD) and Department of Clinical Epidemiology and Public Health, University of Toulouse Hospital, University of Toulouse III-Paul Sabatier, Toulouse, France (S Andrieu); NIA-Layton Aging and Alzheimer's Disease Research Center, Department of Neurology, Oregon Health and Science University, Portland OR, USA (G L Bowman ND MPH); Helfgott Research Institute, National University of Natural Medicine, Portland OR, USA (G L Bowman); Department of Neurology, Donders Institute from Brain, Behavior and Cognition, Radboud University Medical Centre, Nijmegen, Netherlands (E Richard MD PhD); Department of Public and Occupational Health, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands (E Richard); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Davie FL, USA (B Albensi PhD); St Boniface Hospital Research Center, Winnipeg MB, Canada (B Albensi); Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg MB, Canada (B Albensi); Alzheimer's Association, Chicago, IL, USA (E Meyers PhD, M Solis PhD, M Carrillo PhD, H Snyder PhD); Department of Neurology, Aiginitio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece (N Scarmeas).
Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention.
View Article and Find Full Text PDFSystemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people.
J Neuroinflammation
May 2022
Institute for Regenerative Medicine, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Background: Neuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer's disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory alterations associated with neuropsychiatric symptoms (NPS); and to investigate their relationships with AD pathology and clinical disease progression.
Methods: We quantified a panel of 38 neuroinflammation and vascular injury markers in paired serum and cerebrospinal fluid (CSF) samples in a cohort of cognitively normal and impaired older subjects.
Including older rural adults in research: Practical guidance for addressing the NIH Inclusion Across the Lifespan policy.
J Clin Transl Sci
February 2020
Division of General Internal Medicine & Geriatrics, Oregon Clinical & Translational Research Institute, Oregon Health & Science University, Portland, OR, USA.
Article Synopsis
- The study explores factors influencing the participation of older adults (OAs) in research, specifically focusing on rural populations in Oregon.
- Key themes identified include motivations like improving health outcomes and social engagement, as well as barriers such as transportation issues and privacy concerns.
- Recommendations for researchers include engaging with OAs in their communities, providing transportation, and ensuring transparency to build trust in research efforts.
Training the next generation of aging and cognitive health researchers.
Gerontol Geriatr Educ
May 2022
School of Nursing and an Investigator with the Health Promotion Research Center, School of Public Health, University of Washington, Seattle, WA, USA.
Dementia is a growing public health concern, and African Americans and Latinos are disproportionately affected compared to White Americans. Improving cognitive health outcomes and reducing disparities requires a diverse, interdisciplinary workforce. The US Centers for Disease Control and Prevention's Healthy Brain Research Network (HBRN) Scholars Program trained racially/ethnically and gender-diverse scholars through mentored, collaborative research.
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