14 results match your criteria: "NHO Sendai Medical Center[Affiliation]"
Nelarabine-combined chemotherapy improves outcome of T-cell acute lymphoblastic leukemia but shows more severe neurotoxicity: JALSG T-ALL213-O.
Cancer Sci
November 2024
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
We investigated the effectiveness and safety of nelarabine (NEL)-combined chemotherapy for newly diagnosed adult T-cell acute lymphoblastic leukemia (T-ALL) patients. We conducted a phase II trial, T-ALL213-O, where adult T-ALL patients aged 25 to 64 were treated by a regimen based on that used in our previous study, ALL202-O. The main modifications from ALL202-O to T-ALL213-O were as follows: (1) NEL-combined chemotherapy, instead of consolidation (C)1, was used for non-complete remission (CR) patients after induction therapy (IND)1 as IND2; (2) NEL treatments were inserted into C3 and C5 on day 29.
View Article and Find Full Text PDFPhase II Trial of Romidepsin as Consolidation Therapy after Gemcitabine, Dexamethasone, and Cisplatin in Elderly Transplant-Ineligible Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma.
Hematol Rep
May 2024
Department of Hematology, Clinical Research Institute, NHO Kyushu Medical Center, Fukuoka 810-0065, Japan.
Article Synopsis
- - Romidepsin is a promising treatment for patients with peripheral T-cell lymphoma (PTCL), but its timing in therapy remains debated; this study aimed to assess its safety and effectiveness after GDP therapy.
- - Conducted from March 2019 to March 2021, the study involved 7 patients with relapsed/refractory PTCL and found a 2-year overall survival rate of 71% and a 57% overall response rate after treatment.
- - Although common side effects included neutropenia, which was manageable, no treatment-related deaths occurred, suggesting that the GDP plus romidepsin regimen may be a safe option for older patients not eligible for transplants; however, further research is necessary.
Timing of initial symptom onset during milk and wheat challenges: A retrospective study.
Immun Inflamm Dis
February 2024
Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
Background: Allergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices. The reported median times for the first symptom occurrence are 20-30 min with milk and 50-60 min with eggs. However, allergic reactions due to wheat have not yet been fully investigated.
View Article and Find Full Text PDF[Eculizumab led to beneficial clinical course in a patient with generalized myasthenia gravis who developed COVID 19-associated pneumonia].
Rinsho Shinkeigaku
February 2024
Department of neurology, NHO Sendai Medical Center.
Article Synopsis
- A 74-year-old woman with a long history of myasthenia gravis (MG) and prior thymoma surgery was treated with eculizumab, which helped reduce her MG symptoms over time.
- During a recent hospitalization for mild COVID-19 pneumonia, she received treatments for her pneumonia but did not receive eculizumab, as it wasn't covered by insurance and her MG symptoms were stable.
- The case suggests that eculizumab could potentially be safe for MG patients during COVID-19, as it may inhibit excessive complement activation linked to severe pneumonia risks in these patients.
Reduced antiviral seropositivity among patients with inflammatory bowel disease treated with immunosuppressive agents.
Scand J Gastroenterol
April 2023
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Article Synopsis
- IBD patients have lower immunity levels against certain viruses (measles, rubella, mumps, varicella) compared to healthy control subjects, indicating a potential risk when starting immunosuppressive therapy.
- The study included 437 IBD patients (with ulcerative colitis and Crohn's disease) and 225 healthy individuals, finding significant differences in seropositivity, particularly for patients with ulcerative colitis.
- Screening for immunity to these viruses in IBD patients is recommended before they begin immunosuppressive treatment to prevent potential complications.
Stent-Assisted Embolization for Acutely Ruptured Aneurysm.
J Neuroendovasc Ther
July 2021
Department of Neurosurgery, NHO Sendai Medical Center, Sendai, Miyagi, Japan.
Objective: The purpose of this study was to report the results of stent-assisted embolization performed at our hospital for acutely ruptured aneurysms.
Methods: This study consisted of 19 patients (4 men and 15 women) with acutely ruptured wide neck aneurysm who underwent stent-assisted coil embolization in acute stage between December 2016 and October 2020. Stent-assisted embolization in the acute stage was performed for very wide neck ruptured aneurysm only when balloon-assisted embolization was failed or was thought to be impossible.
Introduction: The previous randomized phase 3 trial (SELECT BC) showed that S-1 as a first-line chemotherapy for metastatic breast cancer (MBC) is non-inferior to taxane with respect to overall survival. This study aimed to identify the usefulness of metabolism-related genes as predictive biomarkers for the response to S-1 compared with taxane using tumor tissue samples from the previous trial. PATIENTS AND METHODS: In this SELECT BC-EURECA study, 147 patients with human epidermal growth factor 2 (HER2)-negative MBC who received either S-1 or taxane were evaluated.
View Article and Find Full Text PDFTrans-Cell Technique through Mesh of Pipeline Embolization Device: A Case Report.
J Neuroendovasc Ther
September 2020
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Objective: We report a case of coil embolization using trans-cell technique through mesh of a pipeline embolization device (PED).
Case Presentation: A 55-year-old female developed a left cavernous carotid aneurysm (CCA) with left abducens nerve palsy. The abducens nerve palsy improved gradually after PED deployment for the aneurysm.
Preservation of Branching Vessel Using Super Compliant Double-Lumen Balloon Microcatheter: Bulging Neck Plasty Technique and Other Options.
J Neuroendovasc Ther
December 2020
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Objective: There are several methods to treat wide-neck aneurysms. We survey the cases that were treated using a super-compliant double-lumen balloon microcatheter (Super-Masamune) for preservation of the branching vessel originating proximal to the aneurysm, especially in the bulging neck plasty (BNP) technique.
Methods: We assessed 10 cases in which branching vessel preservation was performed using Super-Masamune.
Intraaneurysmal Neck Plasty: Efficacy of a Super Compliant Double-Lumen Balloon Microcatheter.
J Neuroendovasc Ther
December 2020
Department of Neurosurgery, NHO Sendai Medical Center, Sendai, Miyagi, Japan.
Objective: While wide-neck aneurysms can be treated with several methods, we report the specific technique of intraaneurysmal neck plasty (IANP) with a super compliant double-lumen balloon microcatheter (Super-Masamune).
Methods: The Super-Masamune was inflated inside 18 aneurysms. Cases in which the tip of the Super-Masamune was located in the aneurysm were included.
Carotid Artery Stenting Using Balloon-Expandable Coronary Stent: Intentional Use for Staged Angioplasty.
J Neuroendovasc Ther
January 2021
Department of Neurosurgery, NHO Sendai Medical Center, Sendai, Miyagi, Japan.
Objective: We report carotid artery stenting (CAS) using balloon-expandable coronary (BECo) stent. The materials in this study consist of 15 cases of high-grade stenosis in internal carotid artery (ICA) in which self-expanding carotid (SECa) stent was not utilized. There were two groups why BECo stent was used instead of SECa stent: alternative group and intentional group.
View Article and Find Full Text PDFDevelopment of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ―.
Circ J
October 2019
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University.
Article Synopsis
- * A systematic review and the modified Delphi method were used to create 29 QIs, and we found that measuring adherence to 6 of these QIs was feasible based on data from over 396,000 stroke patients.
- * The study revealed significant variation in adherence rates among hospitals, indicating that the DPC database can efficiently collect data for evaluating stroke care quality at a lower cost.
Predominance of PCR-ribotypes, 018 (smz) and 369 (trf) of Clostridium difficile in Japan: a potential relationship with other global circulating strains?
J Med Microbiol
October 2015
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan.
Article Synopsis
- A study examined 120 Clostridium difficile isolates from patients in Japan across multiple hospitals during non-outbreak periods from 2011 to 2013, alongside isolates from outbreak settings in previous years.
- The most common strains identified were Japan-ribotypes smz (39.2%) and trf (15.8%), with type smz later classified as PCR-ribotype 018 and trf assigned a new ribotype, PCR-ribotype 369.
- High resistance rates against several antibiotics were noted in PCR-ribotype 018 isolates, highlighting the need for further molecular research to investigate potential evolutionary connections with related strains in Europe and North America.