21 results match your criteria: "NHO Iwakuni Clinical Center[Affiliation]"
Cancers (Basel)
December 2024
Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Limited data are available on the frequency and significance of body weight loss during cancer therapy. This study investigated the frequency of patients who experienced body weight loss during immune checkpoint inhibitor (ICI) plus chemotherapy for advanced non-small cell lung cancer (NSCLC) and the impact of weight loss on treatment outcomes. Using the clinical data of 370 patients with NSCLC who received a combination of ICI and chemotherapy at 13 institutions, this study investigated the frequency of body weight loss > 5% during treatment and determined the impact of body weight loss on patient outcomes.
View Article and Find Full Text PDFJ Clin Exp Hematop
November 2024
Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan.
Sci Rep
November 2024
Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Suruga-ku, Shizuoka, Shizuoka, 422-8002, Japan.
Acta Med Okayama
October 2024
Department of Pediatrics, NHO Iwakuni Clinical Center.
Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms.
View Article and Find Full Text PDFRamucirumab (RAM) has been approved for the treatment of non-small cell lung cancer (NSCLC). Here, we report two cases of RAM-induced ascites with epidermal growth factor receptor-mutant NSCLC. Patient 1, a 72-year-old man, developed ascites 20 months after erlotinib (ERL) and RAM administration, which resolved after their discontinuation and performing paracentesis.
View Article and Find Full Text PDFRespir Investig
November 2024
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, Japan. Electronic address:
Surg Today
July 2024
Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Intern Med
May 2024
Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Eosinophilic pneumonia is a known side effect of dupilumab; however, diffuse alveolar hemorrhage has not yet been reported in association with dupilumab. We herein report a case of diffuse alveolar hemorrhage caused by dupilumab. A 57-year-old man with severe asthma was unable to discontinue oral steroids and thus was prescribed dupilumab.
View Article and Find Full Text PDFInt J Cancer
May 2024
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
The relationships between the therapeutic effects of immune checkpoint inhibitors (ICIs) and the intestinal flora have attracted increasing attention. However, the effects of oral probiotics on the efficacies of ICIs used to treat non-small-cell lung cancer (NSCLC) remain unclear. We investigated the effects of probiotics on the efficacies of ICIs in patients treated with and without chemotherapy.
View Article and Find Full Text PDFJ Surg Case Rep
June 2023
Department of Surgery, NHO Iwakuni Clinical Center, Yamaguchi, Japan.
Leiomyomas are benign smooth muscle tumors, and retroperitoneal leiomyomas without coexisting uterine leiomyomas are extremely rare. Mitotically active leiomyomas, which are leiomyomas with increased mitotic activity, are rarely observed in postmenopausal women, except under the influence of exogenous hormones. This report presents a rare case of a retroperitoneal mitotically active leiomyoma in a postmenopausal woman.
View Article and Find Full Text PDFCancers (Basel)
December 2022
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Objectives: Combined immune checkpoint inhibitor (ICI) therapy and chemotherapy has become the standard treatment for advanced non-small-cell lung cancer (NSCLC). Pleural effusion (PE) is associated with poor outcomes among patients with NSCLC undergoing chemotherapy. However, minimal data exists on PE for patients undergoing combined ICI and chemotherapy.
View Article and Find Full Text PDFThorac Cancer
January 2023
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
Background: COVID-19 incidence is high in patients with cancer. The fatality rate was high for the Delta variant, necessitating infection prevention by vaccination. This study evaluated the safety of a SARS-CoV-2 vaccine in patients with advanced lung cancer receiving anticancer therapy.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
July 2023
Department of Allergy and Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-Cho Kita-Ku Okayama City, Okayama, 700-8558, Japan.
Background: Combination therapy with immune checkpoint inhibitors (ICIs) and chemotherapy (ICI + chemotherapy) has become the standard first line treatment for driver oncogene-negative advanced non-small-cell lung cancer (NSCLC). However, it may be more toxic compared to monotherapy, which limits its use. Moreover, the feasibility of the combination therapy in clinical practice remains unknown.
View Article and Find Full Text PDFRespir Med Case Rep
April 2022
Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan.
Immunoglobulin G4 (IgG4)-related pleurisy is a rare type of IgG4-related disease. We present the case of a 69-year-old woman with left pleural effusion and elevated adenosine deaminase levels. Initially, tuberculous pleuritis was suspected; however, the bacterial cultures and polymerase chain reaction test results for tuberculosis were negative.
View Article and Find Full Text PDFInt J Clin Oncol
July 2022
Department of Allergy and Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama City, Okayama, 700-8558, Japan.
Thorac Cancer
February 2022
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
Background: Since 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become prevalent worldwide. In severe cases, the case fatality rate is high, and vaccine prevention is important. This study evaluated the safety of receiving SARS-CoV-2 vaccine in patients with advanced lung cancer receiving anticancer therapy.
View Article and Find Full Text PDFSupport Care Cancer
September 2021
Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
Background: Radiation esophagitis is a critical adverse event that needs to be appropriately managed while administering thoracic irradiation. This trial aimed to investigate whether sodium alginate has preventative effects on esophagitis in patients with non-small-cell lung cancer (NSCLC) receiving concurrent chemoradiotherapy (CRT).
Methods: Patients with untreated stage III NSCLC who were eligible for concurrent CRT were randomly assigned at a 1:1:1 ratio to receive one of the following treatments: initial or late use of oral sodium alginate (arms A and B) or water as control (arm C).
Cancer Med
April 2020
Graduate School of Medicine, Osaka City University, Osaka, Japan.
Background: To report the follow up data and clinical outcomes of the JME study (UMIN 000008177), a prospective, multicenter, molecular epidemiology examination of 876 surgically resected non-small-cell lung cancer (NSCLC) cases, and the impact of somatic mutations (72 cancer-associated genes) on recurrence-free survival (RFS) and overall survival (OS).
Methods: Patients were enrolled between July 2012 and December 2013, with follow up to 30th November 2017. A Cox proportional hazards model was used to assess the impact of gene mutations on RFS and OS, considering sex, smoking history, age, stage, histology, EGFR, KRAS, TP53, and number of coexisting mutations.
J Cardiol Cases
September 2019
Department of Cardiology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
A 75-year-old man presented to the hospital with a low-grade fever and worsening dyspnea. Transthoracic echocardiogram and contrast-enhanced computed tomography revealed a 20 × 20 mm lesion adjacent to the left ventricle with pericardial effusion. We suspected pericardial abscess, but no bacteria were detected even after 6 consecutive blood cultures.
View Article and Find Full Text PDFCurr Urol
June 2018
Department of Radiology, Okayama University, Okayama, Japan.
Introduction: Gadobutrol (Gd-DO3A-butrol) (Gadovist®) is a macrocyclic gadolinium-based contrast agent for magnetic resonance imaging (MRI) formulated at 1.0 mmol Gd/ml. Gadobutrol's higher concentration compared to other contrast agents (0.
View Article and Find Full Text PDFJ Thorac Oncol
March 2015
*Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan; †Department of Hematology/Oncology, Vanderbilt Vanderbilt University Medical Center, Nashville, TN; ‡Department of Respiratory Medicine, NHO Shikoku Cancer Center, Matsuyama, Japan; §Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan; ‖Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center, Ube, Japan; ¶Department of Respiratory Internal Medicine, Japanese Red Cross Kobe Hospital, Kobe, Japan; #Division of Clinical Oncology, Sumitomo Besshi Hospital, Niihama, Japan; **Department of Clinical Research, NHO Yamaguchi-Ube Medical Center, Ube, Japan; ††Department of Respiratory Medicine, Japanese Red Cross Okayama Hospital, Okayama, Japan; ‡‡Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; and §§Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.
Purpose: Whether bevacizumab enhances the effect of the epidermal growth factor receptor (EGFR) inhibitor gefitinib on EGFR mutant non-small cell lung cancers (NSCLCs) remains unknown. We conducted a phase II trial to investigate the efficacy and safety of gefitinib when combined with bevacizumab as first-line therapy in patients with advanced NSCLC harboring EGFR gene mutations.
Methods: In this trial, 42 patients with a performance status of 0 to 2 received gefitinib (250 mg/d) and bevacizumab (15 mg/kg, every 3 weeks).