9 results match your criteria: "NHO Beppu Medical Center[Affiliation]"
-related neurodevelopmental disorders: a systematic review on genotype-phenotype correlations.
J Med Genet
January 2025
Department of Pediatrics, NHO Beppu Medical Center, Beppu, Oita, Japan
Introduction: Genotype-phenotype correlations in -related neurodevelopmental disorders (-NDDs) remain unclear. This systematic review aimed to clarify these correlations.
Methods: Searches of PubMed and Embase were conducted on 8 August 2024 to identify studies that had investigated genetically diagnosed NDDs (5q31.
Effects of meropenem supply restriction: A multicenter retrospective study.
J Infect Chemother
January 2025
Department of Pharmacy, Clinical Research Institute, NHO Kyushu Medical Center, 1-8-1 Jigyouhama, Chuo-ku, Fukuoka 810-8563, Japan.
Background: In Japan, the supply of one generic meropenem product was restricted from August 2022 to March 2023.
Objective: To determine the effects of meropenem (MEPM) restriction.
Methods: We conducted a multicenter retrospective study comparing antimicrobial use, bacteremia mortality, and drug-resistant bacteria detected before the restriction of MEPM (control period), from September 2021 to February 2022, and after the restriction of MEPM (MEPM supply restriction period), from September 2022 to February 2023, in five institutions.
Article Synopsis
- The study investigates how new antirheumatic drugs affect the characteristics of lymphoproliferative disorder (LPD) in rheumatoid arthritis (RA) patients, using data from 53 hospitals in Japan between 1999 and 2021.
- A total of 752 patients with RA-associated LPD were compared to 770 with sporadic LPD, revealing notable differences in their clinical features and the impact of various drug combinations.
- The findings suggest that medications taken before LPD onset may alter its characteristics, and recommend tocilizumab (TCZ) as a better treatment option after LPD has developed.
Prognostic Impact of Central Nervous System Recurrence After Surgery in Patients With Epidermal Growth Factor Receptor Mutation-positive Non-small-cell Lung Cancer.
Anticancer Res
August 2023
Department of General Thoracic Surgery, NHO Beppu Medical Center, Beppu, Japan.
Background/aim: Adjuvant therapy using third-generation tyrosine kinase inhibitors (TKI) demonstrated improved central nervous system (CNS) disease-free survival after surgery in patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer. However, the prognostic impact of CNS recurrence in surgical patients remains unknown. We evaluated the effect of CNS recurrence on post-recurrence survival (PRS) in patients with postoperatively recurrent NSCLC.
View Article and Find Full Text PDFLack of association between a disease-susceptible single-nucleotide polymorphism, rs2230926 of , and tumour necrosis factor inhibitor therapeutic failure in Japanese patients with rheumatoid arthritis.
Scand J Rheumatol
May 2020
Department of Rheumatology and Allergology, NHO Osaka Minami Medical Center, Kawachinagano, Japan.
Hypozincemia is associated with human hepatocarcinogenesis in hepatitis C virus-related liver cirrhosis.
Hepatol Res
October 2019
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Aim: Hypozincemia is associated with the progression of chronic liver diseases, but it is unknown whether hypozincemia promotes human hepatocarcinogenesis. Our aim is to evaluate the serum zinc levels in liver cirrhosis (LC) patients and clarify the relationship between the serum zinc levels and the development of hepatocellular carcinoma (HCC).
Methods: Cirrhotic patients without HCC (n = 299) were enrolled from 14 medical institutes in Japan as a multicenter prospective study (No.
The Prevalence and Implication of Zinc Deficiency in Patients With Chronic Liver Disease.
J Clin Med Res
May 2018
Department of Nutritional Science, Morioka University, 808 Sunakomi, Takizawa 020-0694, Japan.
Article Synopsis
- Patients with liver cirrhosis commonly suffer from zinc deficiency, which may relate to their clinical symptoms and liver function.
- A study involving 235 cirrhosis patients found strong correlations between blood zinc levels and factors such as blood albumin, age, and liver test results.
- The research emphasizes that low zinc levels are prevalent in patients with conditions like edema and hepatic encephalopathy, suggesting that those with nitrogen metabolic disorders should be evaluated for zinc deficiency.
Early therapeutic intervention with methotrexate prevents the development of rheumatoid arthritis in patients with recent-onset undifferentiated arthritis: A prospective cohort study.
Mod Rheumatol
September 2016
a Department of Clinical Research , NHO Osaka Minami Medical Center, Kawachinagano, Osaka , Japan.
Article Synopsis
- The study looked at whether giving a medicine called methotrexate (MTX) early can stop people with early-stage arthritis from getting rheumatoid arthritis (RA).
- Two groups of patients were tested: one group got MTX, and the other didn't.
- The results showed that only 17.2% of the group taking MTX developed RA, while 78.9% of the group not taking it did, suggesting that MTX is effective in preventing RA.
Branched-chain amino acids prevent hepatocarcinogenesis and prolong survival of patients with cirrhosis.
Clin Gastroenterol Hepatol
June 2014
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan. Electronic address:
Background & Aims: Although a low plasma level of branched-chain amino acids (BCAAs) is a marker of cirrhosis, it is not clear whether BCAA supplements affect disease progression. We performed a multicenter study to evaluate the effects of BCAA supplementation on hepatocarcinogenesis and survival in patients with cirrhosis.
Methods: We enrolled 299 patients from 14 medical institutions in Japan in a prospective, multicenter study in 2009; 267 patients were followed through 2011.