5 results match your criteria: "NHMRC Clinical Trials Centre at the University of Sydney[Affiliation]"
Most older people with kidney failure choose between treatment with dialysis or conservative kidney management. The preferences underlying these decisions are poorly understood. Here, we performed a choice experiment, informed by qualitative research, to examine preferences for the characteristics of dialysis and conservative management among over-65-year-olds with eGFR of 20 mls or under/min/1.
View Article and Find Full Text PDFThe Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions.
Diabetes Care
April 2022
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Background: The epidemiology of adult-onset type 1 diabetes (T1D) incidence is not well-characterized due to the historic focus on T1D as a childhood-onset disease.
Purpose: We assess the incidence of adult-onset (≥20 years) T1D, by country, from available data.
Data Sources: A systematic review of MEDLINE, Embase, and the gray literature, through 11 May 2021, was undertaken.
Day 1 to day 4 serum hCG change in predicting single-dose methotrexate treatment failure for tubal ectopic pregnancies.
Eur J Obstet Gynecol Reprod Biol
December 2020
Department of Obstetrics and Gynaecology, Westmead Hospital, Hawkesbury Rd, Westmead, New South Wales, 2145, Australia; Sydney West Advanced Pelvic Surgery Unit, 6 Kempsey St, Blacktown, New South Wales, 2148, Australia; The University of Sydney School of Medicine, Sydney, New South Wales, 2006, Australia. Electronic address:
Objective: To determine if changes in Day 1 to Day 4 serum human chorionic gonadotropin (hCG) levels can predict treatment failure of single-dose methotrexate (MTX) in medical management of tubal ectopic pregnancies (EP).
Study Design: This retrospective cohort study was conducted at a tertiary level hospital. Files were reviewed for all women who received at least one dose of 50 mg/m intramuscular MTX for treatment of ultrasound-confirmed tubal EPs between 2013 and 2018.
Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study.
Diabetes Care
February 2020
University of Melbourne, Department of Medicine, Melbourne, Australia
Objective: To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis.
Research Design And Methods: Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70-180 mg/dL) for 24-h post-exercise commencement.
Quality of life in patients with advanced epithelial ovarian cancer (EOC) randomized to maintenance pazopanib or placebo after first-line chemotherapy in the AGO-OVAR 16 trial. Measuring what matters-patient-centered end points in trials of maintenance therapy.
Ann Oncol
March 2018
AGO Germany (leading group within this GCIG consortium); Department of Gynecology & Gynecologic Oncology, Kliniken Essen Mitte, Essen, Germany.
Background: Health-related quality of life (HRQoL) was a secondary end point in AGO-OVAR 16, which randomized 940 patients with EOC after first-line chemotherapy to maintenance pazopanib (PZ) or placebo (P). Additional post hoc analyses were carried out to investigate additional patient-centered end points.
Patients And Methods: HRQoL was measured with EORTC-QLQ-C30, QLQ-OV28 and EQ-5D-3L.