2 results match your criteria: "NHLS Tygerberg and Stellenbosch University[Affiliation]"
African KhoeSan ancestry linked to high-risk prostate cancer.
BMC Med Genomics
June 2019
Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, NSW, 2010, Australia.
Article Synopsis
- The study looks at genetic diversity, especially focusing on people from Africa, particularly the KhoeSan group, and how their ancestry might impact prostate cancer risk.
- Researchers studied 152 South African men, finding that about 40% had a serious type of prostate cancer linked to their African ancestry.
- They discovered that a specific part of the KhoeSan ancestry is connected to higher chances of getting this kind of cancer, pointing out four genetic locations that might be important for understanding this risk.
Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.
J Acquir Immune Defic Syndr
April 2011
Division of Medical Virology, Department of Pathology, NHLS Tygerberg and Stellenbosch University, Tygerberg, South Africa.
Background: In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic failure.
Methods: We conducted a cross-sectional survey to investigate the aetiology of virologic failure in 2 public health antiretroviral clinics in South Africa documenting the prevalence of virologic failure (HIV RNA load >500 copies/mL) and genotypic antiretroviral resistance; and lopinavir hair and plasma concentrations in a nested case-control study.
Results: Ninety-three patients treated with a second-line regimen including lopinavir boosted with ritonavir were included, of whom 50 (25 cases, with virologic failure and 25 controls) were included in a nested case control study.