506 results match your criteria: "NHC Key Laboratory of Myopia (Fudan University)[Affiliation]"
Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.
Ann Med
December 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Objective: To evaluate the longitudinal changes in the effective optical zone (EOZ) following hyperopic keratorefractive lenticule extraction (KLEx) and investigate factors influencing the EOZ.
Patients And Methods: This retrospective study included 27 patients who underwent hyperopic KLEx. According to the transition zone (TZ) sizes, they were divided into two groups: group A (21 eyes) with a 2.
Pulsed Ultrasound-Mediated Drug Delivery Enhancement Through Human Sclera.
Transl Vis Sci Technol
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: The purpose of this study was to characterize whether pulsed ultrasound (PUS) affects transscleral drug delivery.
Methods: Fluorescein sodium (NaF, 376 Da) and fluorescein isothiocyanate-conjugated dextran 40 (FD-40, 40 kDa) were used as model drugs. Human sclera grafts were placed in modified Franz diffusion cells and were treated by PUS (1 megahertz [MHz], 0.
Comparison of two strategies estimating surgically induced astigmatism in position prediction of toric IOLs in 2.2 mm cataract surgery.
Graefes Arch Clin Exp Ophthalmol
December 2024
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, No. 83 Fenyang Road, Shanghai, 200031, China.
Purpose: To compare the precision of the arithmetic mean of surgically induced astigmatism (M-SIA) and the centroid of surgically induced astigmatism (C-SIA) in estimating SIA when predicting the power and axis of toric IOLs under different circumstances.
Methods: 120 eyes of 99 patients undergoing toric IOL replacement in a simple cataract surgery were included in the retrospective study. The predicted position of toric IOL was calculated by Z Calc online calculator and Barrett Toric Calculator with M-SIA (0.
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Background: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye.
Purpose: This study explored the potential therapeutic role and underlying mechanisms of NE in benzalkonium chloride (BAC)-induced dry eye disease.
Anterior Segment Pharmacological Accommodative Changes and Its Impact on the Circumferential Anterior Chamber Angle after ICL V4c Implantation: Angle following ICL implantation.
J Cataract Refract Surg
December 2024
Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China.
Purpose: To investigate the pharmacological accommodative changes of the anterior segment and its impact on the circumferential anterior chamber angle (ACA) after implantable collamer lens (ICL) implantation using swept-source optical coherence tomography (SS-OCT).
Setting: Eye and ENT Hospital, Fudan University, Shanghai, CHINA.
Design: Prospective randomized contralateral eye study.
MIU-Net: Advanced multi-scale feature extraction and imbalance mitigation for optic disc segmentation.
Neural Netw
February 2025
Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address:
Article Synopsis
- - Pathological myopia is a serious eye condition that can lead to severe vision complications, and optic disc segmentation is crucial for early detection but faces challenges in accuracy.
- - The proposed MIU-Net model enhances segmentation performance using a multi-scale feature extraction module and a dual attention module, which improve the model's ability to identify the optic disc in complex images.
- - By implementing focal loss to address pixel imbalance and applying data augmentation for better training, MIU-Net shows significant improvements in accuracy and robustness in tests, indicating its potential for diagnosing pathological myopia.
Genetic Estimates of Correlation and Causality Between Keratoconus and Osteoarthritis.
Cornea
October 2024
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Article Synopsis
- The study investigates the possible genetic link between keratoconus (KC) and osteoarthritis (OA), as previous hypotheses suggested a relationship but lacked clear evidence.
- Using various genetic analysis methods on large datasets, the researchers looked for correlations and causal relationships between KC and OA.
- The findings indicate no significant genetic connection or causal relationship between KC and OA, suggesting that keratoconus does not increase the risk of developing osteoarthritis.
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects.
Drugs Aging
November 2024
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China.
Presbyopia is a common age-related visual impairment. With the aging of the population, the incidence of presbyopia is increasing globally, becoming a worldwide public health concern. Treatment options for presbyopia include optical lens correction, surgical intervention, and pharmacological therapy.
View Article and Find Full Text PDFIncision-related astigmatism on the anterior and total cornea after implantable collamer lens implantation.
Indian J Ophthalmol
November 2024
Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
Purpose: To evaluate incision-related astigmatism (IRA) on the anterior and total cornea after implantable collamer lens (ICL) implantation through superior and temporal corneal incisions.
Methods: The retrospective study included 141 eyes of 80 consecutive patients who underwent ICL implantation. An ocular examination was performed preoperatively and at 1 and 6 months postoperatively.
Characteristics of the fundus and optical coherence tomography angiography metrics in myopic patients with myelinated retinal nerve fibers.
BMC Ophthalmol
October 2024
Department of Ophthalmology, EYE & ENT Hospital of Fudan University, 19 Baoqing Road, Shanghai, 200031, China.
Aims: To investigate the fundus characteristics and macular optical coherence tomography angiography (OCTA) metrics in patients with myelinated retinal nerve fibers (MRNF) and to identify the associations among myopic parameters, fundus metrics, and OCTA metrics.
Methods: The single-center case-control study included 15 patients with monocular MRNF and 15 patients without MRNF, matched for age, affected eyes' spherical equivalent error (SER), and axial length (AL) between May 2021 and December 2021. Fundus features, including the entire MRNF area (Area1), the denser MRNF area (Area2), and the shortest distance from the fovea to the MRNF border (D), along with ocular parameters, including SER, AL, best corrected visual acuity (BCVA), and OCTA metrics at the fovea, including choroidal (ChT) and retinal (ReT) thicknesses at the fovea, the foveal avascular zone area (FAZ), foveal avascular zone perimeter (FAZP), FAZ-circularity index (FAZ-CI), and foveal vessel density in a 300-µm wide region (FD-300), were assessed.
Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes.
BMC Ophthalmol
October 2024
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Article Synopsis
- The study aimed to compare the contrast sensitivity function (qCSF) in eyes with early keratoconus (Early-KC) and normal control (NC) eyes to understand differences in visual performance.
- Results showed that eyes with Early-KC, even with normal corrected distance visual acuity (CDVA), had significantly lower contrast sensitivity at both low and high spatial frequencies compared to NC eyes.
- The findings indicate that qCSF testing is a useful tool for detecting visual impairments in early keratoconus, as it reveals subtle changes in visual function despite normal acuity measurements.
Short-Term Effect of Stimulating the Pterygopalatine Ganglion Via Electroacupuncture on Choroidal Structure in Human Subjects.
Transl Vis Sci Technol
October 2024
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Article Synopsis
- - The study examines the effects of parasympathetic stimulation via the pterygopalatine ganglion (PPG) on choroidal structure, specifically looking at how electroacupuncture impacts choroidal thickness and vascularity in healthy adults.
- - In a crossover design, 22 participants underwent both PPG stimulation and sham stimulation, with measurements taken before and after each intervention, revealing significant increases in choroidal thickness and vascularity following PPG stimulation.
- - Results showed that while choroidal thickness peaked 15 minutes after stimulation and remained elevated for 60 minutes, choroidal vascularity peaked immediately and then gradually returned to baseline, highlighting the potential of PPG activation for influencing choroidal health
Multiple cytokine analysis of aqueous humor in uveitis with or without secondary glaucoma.
BMC Ophthalmol
October 2024
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- The study evaluated levels of pro-inflammatory and anti-inflammatory cytokines in the aqueous humor of uveitis patients, both with and without glaucoma, and compared them to patients with primary open-angle glaucoma and age-related cataract.
- Using Luminex xMAP® multiplex assays, researchers analyzed 11 cytokines and found significant elevations in pro-inflammatory factors in the aqueous humor of those with uveitis-secondary glaucoma, suggesting a correlation with disease progression.
- The findings indicate that the presence of certain cytokines (like MCP-1, IL-6, and IL-8) might play a role in the glaucomatous changes seen in uveitis patients, and high intraocular pressure did not significantly affect cytokine levels before
Incidence and mechanism of conjunctival chemosis during phacoemulsification.
BMC Ophthalmol
October 2024
Eye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Article Synopsis
- - The study investigates the occurrence of conjunctival chemosis during phacoemulsification surgery, noting that it affected 9.17% of patients and explored its causes and treatments.
- - Researchers recorded the location, timing, and severity of chemosis during surgeries and compared various surgical parameters between affected and unaffected groups.
- - Findings suggest that chemosis is linked to the distance from the clear corneal incision to Bowman's layer, and that proper conjunctival incisions can help prevent chemosis during surgery.
Efficacy of Topical Cyclosporine Combined with Punctal Plugs in Treating Dry Eye Disease and Inflammation.
Curr Eye Res
October 2024
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Article Synopsis
- The study aimed to assess the effectiveness of combining punctal plugs with cyclosporine eye drops in treating dry eye disease (DED) and reducing ocular inflammation.
- In a clinical trial with 73 patients and an animal model, various metrics (like tear production and inflammation markers) were measured before and after treatment across three different groups.
- Results showed that the combination therapy significantly improved eye function and reduced inflammation markers more effectively than using either treatment alone, suggesting it's a superior approach for managing DED.
Quantitative signs on ultrasound biomicroscopy images associated with the status of silicone oil emulsification within the eye.
Sci Prog
September 2024
Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Objectives: Silicone oil (SO) is a commonly used intraocular tamponade in the treatment of rhegmatogenous retinal detachment (RRD). SO emulsification is a common complication after SO injection. This study aimed to investigate correlations between SO emulsification signs on ultrasound biomicroscopy (UBM) and the real number/size of SO droplets.
View Article and Find Full Text PDFMutations in ADAMTSL4 cause a unique form of autosomal-recessive congenital ectopia lentis.
Exp Eye Res
November 2024
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address:
Several unique mutations of ADAMTSL4 leading to congenital ectopia lentis (CEL) have been previously reported by our team. The purpose of this study is to find out the possible mechanism of a recurrent novel intronic variant in ADAMTSL4 led to CEL. Twelve novel ADAMTSL4 mutations with a unique form congenital ectopic lentis were detected previously by panel-based NGS.
View Article and Find Full Text PDFA genetic investigation in five Chinese families with keratoconus.
PeerJ
September 2024
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Background: This study investigated the genetic characteristics of five Chinese families with keratoconus (KC).
Methods: In the five families affected by KC, medical records, clinical observations, and blood samples were collected from all individuals. All KC family members ( = 20) underwent both whole exome sequencing of genomic DNA and Sanger sequencing to confirm the variants.
A Novel Artificial Intelligence-Based Classification of Highly Myopic Eyes Based on Visual Function and Fundus Features.
Transl Vis Sci Technol
September 2024
Eye Institute, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Purpose: To develop a novel classification of highly myopic eyes using artificial intelligence (AI) and investigate its relationship with contrast sensitivity function (CSF) and fundus features.
Methods: We enrolled 616 highly myopic eyes of 616 patients. CSF was measured using the quantitative CSF method.
Comparison of long-term changes in the effective optical zone following SMILE and FS-LASIK for moderate and high myopia.
BMC Ophthalmol
September 2024
Department of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Article Synopsis
- The study investigates the long-term changes in the effective optical zone (EOZ) after two types of corneal refractive surgery: small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (FS-LASIK) for patients with moderate to high myopia.
- A total of 42 patients underwent either SMILE or FS-LASIK, with the EOZ measured at 3 and 7 years post-surgery using specialized software.
- Results showed that EOZ was consistently larger after SMILE compared to FS-LASIK, with both procedures experiencing a decrease in EOZ over time, and SMILE produced fewer spherical aberrations than FS-LASIK.
Changes in anterior segment after short-term scleral lens wear in healthy Chinese population.
Cont Lens Anterior Eye
February 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai 200031, China. Electronic address:
Purpose: To evaluate the impact of short-term scleral lens (SL) wear on anterior chamber (AC) dimension and central corneal thickness (CCT) in healthy Chinese people.
Methods: This is a prospective, daily wear study. Eligible participants were dispensed SLs to correct refractive errors.
Spectacle Lenses With Highly Aspherical Lenslets for Slowing Axial Elongation and Refractive Change in Low-Hyperopic Chinese Children: A Randomized Controlled Trial.
Am J Ophthalmol
January 2025
From the Eye Institute and Department of Ophthalmology (Z.Z., L.Z., J.Z., X.Z., Z.C., D.Y., C.C., X.W., X.Z., Z.C.), Eye & ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia (Z.Z., L.Z., J.Z., X.Z., Z.C., D.Y., C.C., X.W., X.Z., Z.C.), Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry (Z.Z., L.Z., J.Z., X.Z., Z.C., D.Y., C.C., X.W., X.Z., Z.C.), Shanghai, China. Electronic address:
Article Synopsis
- Spectacle lenses with highly aspherical lenslets (HAL) have been shown to slow down the progress of myopia in children, and this study examined their impact on low hyperopic children.
- A total of 108 Chinese children aged 6-9 were divided into two groups, one receiving HAL lenses and the other single vision lenses, with measurements taken over a year.
- Results indicated that children in the HAL group experienced less axial length elongation, especially if they wore their lenses for over 30 hours a week, highlighting a correlation between lens wearing time and eye changes.
Genotype Associated With Visual Prognosis in Patients With Congenital Ectopia Lentis Following Lens Surgery: A Prospective Cohort Study.
Am J Ophthalmol
December 2024
From the Eye Institute and Department of Ophthalmology (W.N.J., Z.X.C., Y.L.W., X.S., X.Y.C., T.H.C., Y.S., Y.L., L.H.S., Q.Y.H., and Y.X.J.), Eye & ENT Hospital, Fudan University, Shanghai China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia (W.N.J., Z.X.C., Y.L.W., X.S., X.Y.C., T.H.C., Y.S., Y.L., L.H.S., Q.Y.H., and Y.X.J.), Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration (W.N.J., Z.X.C., Y.L.W., X.S., X.Y.C., T.H.C., Y.S., Y.L., L.H.S., Q.Y.H., and Y.X.J.), Shanghai, China. Electronic address:
Purpose: To investigate the relationship between visual prognosis and genotype in patients undergoing lens surgery for congenital ectopia lentis (EL).
Design: Prospective clinical cohort study.
Methods: Patients with congenital EL who underwent lens removal and intraocular lens implantation received panel-based next-generation sequencing.
Establishment of a new vault prediction formula after implantable collamer lens implantation based on factor analysis of multi-modal ophthalmic parameters of anterior and posterior chamber.
Clin Exp Ophthalmol
December 2024
Department of Ophthalmology and Optometry, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background: To establish a novel vault prediction formula after implantable collamer lens (ICL) implantation that considers both anterior and posterior chamber characteristics with multi-modal parameters.
Methods: A total of 103 and 65 eyes were included in the development and validation groups, respectively. Exploratory factor analysis was performed using data from optical coherence tomography and ultrasound biomicroscopy in the development group to synthesise summative factors with different clinical significance.
A novel variant in the keratin 12 gene in a four-generation Chinese family with high myopia.
Eye (Lond)
December 2024
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, 200000, China.
Background: High myopia is a major cause of visual impairment, and genetic factors play crucial roles in the pathogenesis. We performed this study to identify candidate genes for the development of high myopia in a four-generation Chinese family with myopia.
Methods: All family members with myopia and 100 healthy participants were included in this study.