Various Sizes and Shapes of Mixed-Anion Fe(NHtrz)(BF)(SiF)@SiO Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature.

Spin crossover (SCO) iron (II) coordination compounds in the form of nanohybrid SCO@SiO particles were prepared using a reverse micelles technique based on the TritonX-100/cyclohexane/water ternary system. Tetraethyl orthosilicate (TEOS) acts as precursor of both the SiF counter-anion and SiO to obtain Fe(NHtrz)(BF)(SiF)@SiO nanoparticles with different sizes and morphologies while modifying the TEOS concentration and reaction time. The adjustable mixed-anion strategy leads to a range of quite scarce abrupt spin crossover behaviors with hysteresis just above room temperature (ca.

Arginylation of ⍺-tubulin at E77 regulates microtubule dynamics via MAP1S.

Arginylation is the posttranslational addition of arginine to a protein by arginyltransferase-1 (ATE1). Previous studies have found that ATE1 targets multiple cytoskeletal proteins, and Ate1 deletion causes cytoskeletal defects, including reduced cell motility and adhesion. Some of these defects have been linked to actin arginylation, but the role of other arginylated cytoskeletal proteins has not been studied.

Serological Profile of Anti- Antibodies in Liver Transplant Recipients.

, a globally distributed obligatory intracellular opportunistic parasite that has infected one third of the world population, has different transmission routes including via organ transplantation. The liver has emerged as a frequent transplanted organ in which the transmission of can occur between seropositive donors and seronegative recipients. Allied with immunosuppressive therapy, the presence of latent infection in recipients elevates the risk of severe toxoplasmosis.

Serious Bacterial Infections and Hepatitis C Virus Among People Who Inject Drugs: A Syndemic or Intertwined Epidemics?

Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.

Anthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral .

New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and H NMR-guided approaches.

Nauplii Enriched with Soybean Lecithin Enhances Growth Performance, Intestine Morphology, and Desiccation Stress Resistance in Yellow Drum () Larvae.

The inherent deficiency of phospholipids in limits its nutritional value as live prey for marine fish larvae. In our previous study, we optimized a phospholipid enrichment method by incubating nauplii with 10 g of soybean lecithin per m of seawater for 12 h, significantly enhancing their phospholipid content. : The present study evaluated the impact of this enrichment on yellow drum () larvae, focusing on growth performance, intestinal morphology, body composition, weaning success, and desiccation stress resistance.

Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing.

Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response.

Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors.

Ammonium Transporter 1 () Gene Family in Pomegranate: Genome-Wide Analysis and Expression Profiles in Response to Salt Stress.

Understanding the ammonium (NH) uptake and transport systems, particularly genes, is important for plant growth and defense. However, there is a lack of research on identifying and analyzing genes in pomegranate, emphasizing the need for further investigation in this area. Five genes ( to ) were identified, all of which contain the PF00909 domain, a feature of ammonium transporters.

Fluorogenic Biosensing with Tunable Polydiacetylene Vesicles.

Polydiacetylenes (PDAs) are conjugated polymers that are well known for their colorimetric transition from blue to red with the application of energetic stimulus. Sensing platforms based on polymerized diacetylene surfactant vesicles and other structures have been widely demonstrated for various colorimetric biosensing applications. Although less studied and utilized, the transition also results in a change from a non-fluorescent to a highly fluorescent state, making polydiacetylenes useful for both colorimetric and fluorogenic sensing applications.

Characterization and Machine Learning-Driven Property Prediction of a Novel Hybrid Hydrogel Bioink Considering Extrusion-Based 3D Bioprinting.

The field of tissue engineering has made significant advancements with extrusion-based bioprinting, which uses shear forces to create intricate tissue structures. However, the success of this method heavily relies on the rheological properties of bioinks. Most bioinks use shear-thinning.

N-Oxalylglycine-Conjugated Hyaluronic Acid as a Macromolecular Prodrug for Therapeutic Angiogenesis.

Hypoxia-inducible factor-1α (HIF-1α) initiates the cellular response to low oxygen levels, making it an attractive target for stimulating therapeutic angiogenesis. Several small molecules have been identified that stabilize HIF-1α and activate the angiogenic signaling pathway. However, achieving therapeutic doses of bioactive small molecules in target tissues remains challenging.

Feasibility and Preliminary Effects of Acupuncture for Cognitive Dysfunction in Diverse Cancer Survivors: A Pilot, Randomized, Placebo-Controlled Trial.

(1) Background: This pilot study evaluates the feasibility and preliminary effects of acupuncture for cancer-related cognitive dysfunction (CRCD) in cancer survivors. (2) Methods: A randomized trial comparing real acupuncture (RA) to sham acupuncture (SA) and waitlist control (WLC) among cancer survivors reporting cognitive difficulties. Interventions were delivered weekly over 10 weeks.

Pain and Frailty in Childhood Cancer Survivors: A Narrative Review.

A significant proportion of childhood cancer survivors experience persistent health problems related to cancer or cancer treatment exposures, including accelerated or early onset of aging. Survivors are more likely than non-cancer peers to present a frail phenotype suggestive of reduced physiologic reserve and have symptoms that interfere with function in daily life, including pain. Studies in the general population, mostly among older adults, suggest that pain is a significant contributor to development and progression of frail health.

Nutritional Counseling During Chemotherapy Treatment: A Systematic Review of Feasibility, Safety, and Efficacy.

Dietary interventions during chemotherapy hold promise for clinical and supportive care outcomes. We systematically investigated the feasibility, safety, and efficacy of nutritional counseling conducted during chemotherapy. Studies prospectively implemented nutrition counseling during chemotherapy.

Trauma, Justice, and Equity: Using Critical Theories and Concepts to Address Systemic Harm Among Youth Punishment System-Involved Black Girls.

This review critically evaluates the existing literature on youth punishment system (YPS)-involved Black girls and their intersections of with trauma and post-traumatic stress disorder (PTSD). It synthesizes findings from previous studies, identifying key research trends, gaps, and controversies, while also highlighting areas in need of further investigation. Black girls, particularly those involved in systems such as juvenile justice, child welfare, and education, often face disproportionate exposure to violence, abuse and neglect, trauma, and systemic racism.

Transport Numbers and Electroosmosis in Cation-Exchange Membranes with Aqueous Electrolyte Solutions of HCl, LiCl, NaCl, KCl, MgCl, CaCl and NHCl.

Electroosmosis reduces the available energy from ion transport arising due to concentration gradients across ion-exchange membranes. This work builds on previous efforts to describe the electroosmosis, the permselectivity and the apparent transport number of a membrane, and we show new measurements of concentration cells with the Selemion CMVN cation-exchange membrane and single-salt solutions of HCl, LiCl, NaCl, MgCl, CaCl and NHCl. Ionic transport numbers and electroosmotic water transport relative to the membrane are efficiently obtained from a relatively new permselectivity analysis method.

Key Role of Phosphorylation in Small Heat Shock Protein Regulation via Oligomeric Disaggregation and Functional Activation.

Heat shock proteins (HSPs) are essential molecular chaperones that protect cells by aiding in protein folding and preventing aggregation under stress conditions. Small heat shock proteins (sHSPs), which include members from HSPB1 to HSPB10, are particularly important for cellular stress responses. These proteins share a conserved α-crystallin domain (ACD) critical for their chaperone function, with flexible N- and C-terminal extensions that facilitate oligomer formation.

Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats.

Rotenone, a naturally occurring compound derived from the roots of tropical plants, is used as a broad-spectrum insecticide, piscicide, and pesticide. It is a classical, high-affinity mitochondrial complex I inhibitor that causes not only oxidative stress, α-synuclein phosphorylation, DJ-1 (Parkinson's disease protein 7) modifications, and inhibition of the ubiquitin-proteasome system but it is also widely considered an environmental contributor to Parkinson's disease (PD). While prodromal symptoms, such as loss of smell, constipation, sleep disorder, anxiety/depression, and the loss of dopaminergic neurons in the substantia nigra of rotenone-treated animals, have been reported, alterations of metabolic hormones and hyperinsulinemia remain largely unknown and need to be investigated.

Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells.

As of 2023, there were 39.9 million people living with Human Immunodeficiency Virus type 1 (HIV-1). Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive.

Gene-Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy.

Arsenic (As) is a risk factor for non-melanoma skin cancer (NMSC). From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor tissue and gene expression. Here, we identify the associations of small deletions (DELs) and transcriptomic profiles in NMSC.

Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models.

Charcot first described ALS in 1869, but the specific mechanisms that mediate the disease pathology are still not clear. Intense research efforts have provided insight into unique neuroanatomical regions, specific neuronal populations and genetic associations for ALS and other neurodegenerative diseases; however, the experimental results also suggest a convergence of these events to common toxic pathways. We propose that common toxic pathways can be therapeutically targeted, and this intervention will be effective in slowing progression and improving patient quality of life.

Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers.

Introduction: The cerebellum is a common lesion site in persons with multiple sclerosis (PwMS). Physiologic and anatomic studies have identified a topographic organization of the cerebellum including functionally distinct motor and cognitive areas. In this study, a recent parcellation algorithm was applied to a sample of PwMS and healthy controls to examine the relationships among specific cerebellar regions, fall status, and common clinical measures of motor and cognitive functions.

Syllable as a Synchronization Mechanism That Makes Human Speech Possible.

Speech is a highly skilled motor activity that shares a core problem with other motor skills: how to reduce the massive degrees of freedom (DOF) to the extent that the central nervous control and learning of complex motor movements become possible. It is hypothesized in this paper that a key solution to the DOF problem is to eliminate most of the temporal degrees of freedom by synchronizing concurrent movements, and that this is performed in speech through the syllable-a mechanism that synchronizes consonantal, vocalic, and laryngeal gestures. Under this hypothesis, syllable articulation is enabled by three basic mechanisms: target approximation, edge-synchronization, and tactile anchoring.

Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A DO Exchange and Freeze-Drying Study.

It is known that ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequences can detect signals from water protons but not collagen protons in short T2 species such as cortical bone and tendons. However, whether collagen protons are visible with the zero echo time (ZTE) MRI sequence is still unclear. In this study, we investigated the potential of the ZTE MRI sequence on a clinical 3T scanner to directly image collagen protons via DO exchange and freeze-drying experiments.

Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells.

Traditional pulp-capping materials like mineral trioxide aggregate (MTA) offer excellent biocompatibility and sealing, but limitations such as prolonged setting time, low bioactivity, and high costs persist. Metformin, with its potential in craniofacial regeneration, could enhance dentin synthesis by targeting pulp cells. This study aimed to: (1) develop a calcium phosphate cement with chitosan (CPCC) with improved physio-mechanical properties; (2) incorporate metformin (CPCC-Met) to assess release; and (3) evaluate human dental pulp stem cells (hDPSCs) response.