72 results match your criteria: "NCIM-Resource Center[Affiliation]"

Article Synopsis
  • A bioactive yellow-red pigment from *Streptomyces kunmingensis* was isolated and characterized, showing strong anti-infective properties against MRSA and Mycobacterium tuberculosis.
  • The pigment, a chromopeptide with a specific chemical formula, was identified using various spectral analyses and exhibited antibacterial effects against Staphylococcus aureus as well as antiproliferative effects on 14 human cancer cell lines.
  • Additionally, it demonstrated effective wound-healing properties in a rat model, highlighting its potential for antimicrobial, wound-healing, and anticancer applications.
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Bacterial nanocellulose (BNC) produced from sorbitol as a sustainable nano-filter for oil-water separation.

Int J Biol Macromol

January 2025

NCIM-Resource Center, Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:

Oil spillage is one of the serious problems for sustainable environment. Bacterial nanocellulose (BNC), a hydrophilic and highly porous material holds a promising material for oil-water separation from contaminants. In the present work, a hydrophilic BNC produced from a sorbitol as the carbon source demonstrated the unique porous symmetrical arrangement having an oleophilic property.

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Bacterial nanocellulose (BNC) has various unique qualities, including high mechanical strength, crystallinity, and high water-holding capacity, which makes it appropriate for a wide range of industrial applications. But its lower yield coupled with its high production cost creates a barrier to its usage. In this study, we have demonstrated the better yield of BNC from an indigenous strain Komagataeibacter rhaeticus MCC-0157 using a rotary disc bioreactor (RDB) having a wooden disc.

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2-Acetyl-1-pyrroline (2AP) is an important and major flavor aroma compound responsible for the fragrance of basmati rice, cheese, wine, and several other food products. Biosynthesis of 2AP in aromatic rice and a few other plant species is associated with a recessive Betaine aldehyde dehydrogenase 2 (BADH2) gene. However, the literature is scant on the relationship between the functional BADH2 gene and 2AP biosynthesis in prokaryotic systems.

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Helical nanographenes have garnered substantial attention owing to their finely adjustable optical and semiconducting properties. The strategic integration of both helicity and heteroatoms into the nanographene structure, facilitated by a boron-oxygen-based multiple resonance (MR) thermally activated delayed fluorescence (TADF), elevates its photophysical and chiroptical features. This signifies the introduction of an elegant category of helical nanographene that combines optical (TADF) and chiroptical (CPL) features.

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Fictibacillus fluitans sp. nov., isolated from freshwater pond.

Arch Microbiol

January 2024

NCIM-Resource Center, CSIR-National Chemical Laboratory, Pune, Maharashtra, 411008, India.

A Gram-positive, aerobic, rod-shaped, spore-forming bacterium, designated NE201, was isolated from a freshwater pond in Village Nerur, India. Growth was observed in the range of 15-45 °C temperature with optimum at 30 °C, pH range of 5-9 (optimum at 7.0), and at concentrations of NaCl ranging between 0 and 14% (optimum 0%, w/v).

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anticancer evaluation of Enceleamycin A and its underlying mechanism.

RSC Adv

November 2023

NCIM-Resource Center, Biochemical Sciences Division, CSIR-National Chemical Laboratory Pune - 411008 India

It has become more crucial than ever to find novel anticancer compounds due to the rise in cancer mortality and resistance to the present chemotherapeutic drugs. Naphthoquinones are regarded as privileged structures for their ability to inhibit various cancers. The current study examined three novel furo-naphthoquinones (Enceleamycins A-C) previously isolated from sp.

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Erythritol has been produced by various microorganisms including Yarrowia, Moniliella, Aureobasidium, and Candida strains. Due to its relatively high price, erythritol sweetener is used lesser than other polyols despite having many advantages. Therefore, in this study, Moniliella pollinis strain was improved for erythritol production by chemical mutagenesis and subsequently screening for cost-effective carbon sources for the enhanced erythritol yield.

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The aim of the present study is to identify actinobacteria Streptomyces bacillaris ANS2 as the source of the potentially beneficial compound 2,4-di-tert-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of S. bacillaris ANS2 to produce the bioactive metabolites.

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An overview of erythritol production by yeast strains.

FEMS Microbiol Lett

November 2022

High Value Chemicals group, Reliance Industries Limited, Ghansoli, Navi Mumbai 400701, India.

Erythritol is a 4-carbon polyol produced with the aid of microbes in presence of hyper-osmotic stress. It is the most effective sugar alcohol that is produced predominantly by fermentation. In comparison to various polyols, it has many precise functions and is used as a flavor enhancer, sequestrant, humectant, nutritive sweetener, stabilizer, formulation aid, thickener, and a texturizer.

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Antifungal compound from marine Serratia marcescens BKACT and its potential activity against Fusarium sp.

Int Microbiol

November 2022

NCIM-Resource Center, Biochemical Science Division, CSIR-National Chemical Laboratory, Dr Homi Bhabha Road, Pune-411008, India.

Ecofriendly biocontrol agents to control pathogenic fungi are in demand globally. The present study evaluated the antifungal potentials of marine bacteria Serratia marcescens BKACT against eight different Fusarium species. A highest 75.

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Three novel furo-naphthoquinones, enceleamycins A-C (-), and a new -hydroxypyrazinone acid () were identified from the strain sp. MCC 0218, isolated from a soil sample collected from the Western Ghats of India. Their chemical structure and absolute and relative configurations were established by 1D and 2D NMR spectroscopy, single-crystal X-ray crystallography, and high-resolution mass spectrometry.

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Isolation and structural characterization of exopolysaccharide from marine Bacillus sp. and its optimization by Microbioreactor.

Carbohydr Polym

June 2022

NCIM Resource Center, CSIR-National Chemical Laboratory, Pune 411008, India; Academy of Scientific and Innovative Research (AcSIR), Gaziabad 201002, India. Electronic address:

In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp. SGD-03 was analysed. FE-SEM analysis has showed the significant fibrillar structure of EPS.

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Cold Active Lipases: Biocatalytic Tools for Greener Technology.

Appl Biochem Biotechnol

July 2021

NCIM Resource Center, CSIR-National Chemical Laboratory, Pune, 411008, India.

Lipases are enzymes that catalyze the ester bond hydrolysis in triglycerides with the release of fatty acids, mono- and diglycerides, and glycerol. The microbial lipases account for $400 million market size in 2017 and it is expected to reach $590 million by 2023. Many biotechnological processes are expedited at high temperatures and hence much research is dealt with thermostable enzymes.

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Molecular insights of fungal endophyte co-inoculation with Trichoderma viride for the augmentation of forskolin biosynthesis in Coleus forskohlii.

Phytochemistry

April 2021

Microbial Technology Laboratory, CSIR- Central Institute of Medicinal and Aromatic Plants, Research Center, Bangalore, 560065, India; Academy of Scientific and Innovative Research, CSIR-CIMAP Campus, Lucknow, Uttar Pradesh, 226015, India; Present address: Food Protectants & Infestation Control (FPIC) Department, CSIR-Central Food Technological Research Institute (CSIR-CFTRI), Mysuru, 570 020, Karnataka, India. Electronic address:

To understand the compatibility of three native endophytic fungi Phialemoniopsis cornearis (SF1), Macrophomina pseudophaseolina (SF2) and Fusarium redolens (RF1) with Trichoderma viride (TV1) on Coleus forskohlii in enhancing plant growth and forskolin content, field experiments were conducted. Co-inoculation of RF1+TV1 showed significant improvement in plant growth (52%), root biomass (67%), and in-planta forskolin content (94%), followed by treatment with SF2+TV1 and SF1+TV1. qRT-PCR was carried out to quantify expression of five key forskolin biosynthetic pathway genes (CfTPS2, CfTPS3, CfTPS4, CfCYP76AH15, and CfACT1-8) in RF1+TV1 treated C.

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Bacterial Biofilm Formation Using PCL/Curcumin Electrospun Fibers and Its Potential Use for Biotechnological Applications.

Materials (Basel)

December 2020

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd Universitario 1000, Unidad Valle de Las Palmas, Tijuana 22260, Baja California, Mexico.

Electrospun nanofibers are used for many applications due to their large surface area, mechanical properties, and bioactivity. Bacterial biofilms are the cause of numerous problems in biomedical devices and in the food industry. On the other hand, these bacterial biofilms can produce interesting metabolites.

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The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gram-negative strains (ATCC 8739), (ATCC 23564) and (ATCC 19154) with a minimum inhibitory concentration of 2.0 µg/mL, 1.

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Culturable bacteria associated with marine sponges and coral mucus (collected from Gulf of Mannar and Palk Bay) were screened for their prospective antimicrobial compounds against 9 bacterial pathogens (Bacillus megaterium, B. cereus, Salmonella typhimurium, Staphylococcus aureus, Proteus vulgaris, Klebsillla pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii) and a fungal pathogen (Candida albicans). Of the 263 bacterial isolates obtained during this study, 52 isolates displayed antimicrobial activity against one or more pathogens.

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Lignocellulosic biomass: Hurdles and challenges in its valorization.

Appl Microbiol Biotechnol

December 2019

NCIM Resource Center, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.

Lignocellulosic biomass (LCB) is globally available and sustainable feedstock containing sugar-rich platform that can be converted to biofuels and specialty products through appropriate processing. This review focuses on the efforts required for the development of sustainable and economically viable lignocellulosic biorefinery to produce carbon neutral biofuels along with the specialty chemicals. Sustainable biomass processing is a global challenge that requires the fulfillment of fundamental demands concerning economic efficiency, environmental compatibility, and social responsibility.

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Development of low-cost plant probiotic formulations of functional endophytes for sustainable cultivation of Coleus forskohlii.

Microbiol Res

October 2019

Microbial Technology Laboratory, CSIR- Central Institute of Medicinal and Aromatic Plants, Research Center, Bangalore, 560065, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:

Deployment of plant endophytes at field level is reported to make an impact on agricultural crop productivity; development and deployment of suitable crop specific plant probiotics in a suitable delivery matrix is a value-added task. In our study, we attempted to develop bioformulations of native, fungal endophytes of Coleus forskohlii to improve plant yield using two different carrier-based materials (talc and wheat bran). Initially, fungal endophytes (RF1, SF1, and SF2) were grown on sterilized wheat bran under solid state condition and their growth kinetics and pattern were analyzed by ergosterol content and scanning electron microscope, respectively.

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Plant Probiotic Bacterial Endophyte, Alcaligenes faecalis, Modulates Plant Growth and Forskolin Biosynthesis in Coleus forskohlii.

Probiotics Antimicrob Proteins

June 2020

Microbial Technology Laboratory, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Center, Bangalore, 560065, India.

Coleus forskohlii is an herb, well-known for its medicinal compound forskolin present in its roots, with wide range of pharmaceutical applications. Here, we report, for the first time, the role of plant-probiotic bacterial endophytes of C. forskohlii, CFLB1 and CFRB1, isolated from leaf and root, which regulate plant growth and in plant forskolin content.

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A novel fatty alkene from marine bacteria: A thermo stable biosurfactant and its applications.

J Hazard Mater

December 2019

NCIM Resource Center, CSIR-National Chemical Laboratory, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory, Pune, 411008, India. Electronic address:

In this study, a novel thermo stable biosurfactants, 1-Pentanonacontene (CH) a fatty alkene and 3-Hydroxy-16-methylheptadecanoic acid (CHO) were isolated from a marine isolate SGD-AC-13. Biosurfactants were produced using 1% yeast extract in tap water as production medium at 24 h in flask and 12 h in bioreactor. Using 16S rRNA gene sequence (1515 bp) and BCL card (bioMérieux VITEK), strain was identified as Bacillus sp.

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The species Bacillus badius is one of the oldest members of the genus Bacillus isolated from faeces of children and was classified based on its ability to form endospores [8]. In 16S rRNA gene sequence and phylogenetic analysis, Bacillus badius DSM 23 shared low similarity (93.0%) and distant relationship with B.

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