The study investigates the relationship between arterial stiffness and atherosclerotic burden in relation to brain structural changes, particularly in Japanese men aged 46 to 83.
Using data from the SESSA study, researchers found that increased arterial stiffness was linked to smaller Alzheimer disease signature brain volumes, while greater atherosclerotic burden correlated with vascular damage in the brain.
The findings suggest that arterial stiffness and atherosclerotic burden affect brain structure independently and potentially through different mechanisms.