51 results match your criteria: "N.N. Alexandrov National Cancer Centre[Affiliation]"
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
PLoS One
April 2016
Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Article Synopsis
- Defective cellular transport processes may contribute to the risk of epithelial ovarian cancer (EOC) by leading to the accumulation of harmful substances that cause DNA damage.
- A study involving DNA samples from over 14,000 EOC cases and nearly 24,000 controls analyzed genetic variations in cellular transport genes using 279 SNPs.
- Significant associations were found, particularly with SNP rs17216603 in the HEPH gene, indicating its influence on invasive cancers and specific tumor subtypes like serous and borderline/low malignant potential tumors.