Click histochemistry for whole-mount staining of brain structures.

Labeling of the replicating DNA with synthetic thymidine analogs is commonly used for marking the dividing cells. However, until now this method has only been applied to histological sections. A growing number of current approaches for three-dimensional visualization of large tissue samples requires detection of dividing cells within whole organs.

Clipping versus coiling in posterior circulation intracranial aneurysms: a meta-analysis.

Background: Posterior circulation intracranial aneurysm (IA) treatment remains challenging, due to the anatomy of the area and the high rupture possibility. Endovascular treatment seems to be more suitable for these aneurysms, but studies focused on endovascular treatment demonstrate a high rate of re-intervention needing. A meta-analysis might offer a clearer view, being useful in a more effective treatment planning.

Radiation Induces Distinct Changes in Defined Subpopulations of Neural Stem and Progenitor Cells in the Adult Hippocampus.

While irradiation can effectively treat brain tumors, this therapy also causes cognitive impairments, some of which may stem from the disruption of hippocampal neurogenesis. To study how radiation affects neurogenesis, we combine phenotyping of subpopulations of hippocampal neural stem and progenitor cells with double- and triple S-phase labeling paradigms. Using this approach, we reveal new features of division, survival, and differentiation of neural stem and progenitor cells after exposure to gamma radiation.

Transoral Decompression and Anterior Stabilization of Atlantoaxial Joint in Patients with Basilar Impression and Chiari Malformation Type I: A Technical Report of 2 Clinical Cases.

Objective: Presentation of clinical cases involving successful anterior stabilization of the C1-C2 segment in patients with invaginated C2 odontoid process and Chiari malformation type I.

Methods: Clinical case description.

Results: Two patients with C2 odontoid processes invagination and Chiari malformation type I were surgically treated using the transoral approach.

Surgical Treatment of Skull Base Tumors, Extending to Craniovertebral Junction.

Objective: To conduct a comparative analysis of 2 groups of patients with skull base chordomas extending onto the craniovertebral junction, who underwent surgical treatment using extracranial approaches with and without craniocervical fusion.

Methods: The study group included 29 patients with skull base chordomas, extending to the craniovertebral junction, who were operated on from 2000 to 2015. The patients underwent the following surgical treatment: posterior craniocervical fusion followed by tumor removal using transoral and combined transoral and transnasal approaches.

Electronic patient records system as a monitoring tool.

Data collected in electronic patient records (EPR) databases may be used for different goals besides their direct purpose - information support for medical staff in their everyday activities. One of the most promising spheres is a monitoring of various processes induced in medical facility. In our studies EPR serves as a basis for healthcare associated infections (HAI) surveillance system at neurosurgical intensive care unit.

Neuro-ophthalmological Features of Cerebral Venous Sinus Thrombosis.

Neuro-ophtalmological symptoms of 49 patients with cerebral venous sinus thrombosis and different onset of the disease were evaluated. Papilloedema was revealed in 84.6% of patients with acute and subacute onset of the disease and in all patients with chronic onset.

Partial disconnection procedure in a patient with bilateral lesions (case report).

Purpose: The method of temporal lobectomy and parietooccipital disconnection has been applied in the treatment of patients with monolateral widespread cortical lesions and with hand motor function intact. There are no data regarding the use of this method in the treatment of patients with bilateral lesions.

Case Report: A case history of a 15-year-old female patient with medically refractory epilepsy is presented.

Local epileptic activity, histological and neuroimaging findings in symptomatic epilepsy.

Objective: This study is aimed at revealing the relationship between local interictal epileptic activity, cytoarchitectural disturbances and magnetic resonance imaging (MRI) findings.

Material And Methods: We prospectively investigated a series of 25 patients with symptomatic epilepsy due to isolated forms of focal cortical dysplasia (FCD) or hippocampal sclerosis and low-grade tumours associated with FCD, all of whom underwent tailored surgical procedures under intraoperative electrocorticography; we conducted neuropathological examinations of 92 biopsies taken from different places. We examined the relationship between dysplastic changes in the cortex and the absence or presence of seizure patterns (SPs), including regular spikes/sharp waves, recruiting discharges, paroxysmal fast activity and rhythmic delta-theta activity.

3-D computer model of subcortical structures of human brain.

Three-dimensional computer model of thalamus and adjacent formations of human brain has been elaborated on the basis of sagittal slices from the Schaltenbrand-Bailey stereotactic atlas. The model includes 120 morphologically distinguishable structures and consists of more than 16 million points (volume elements) each of them being associated with the particular structure in the brain. The model is stored in the long-term computer memory.