International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

Importance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.

Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.

FACTORS ASSOCIATED WITH DECLINE OF FEV1 IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

The purpose of the study was to search for a correlation between FEV1 and the possible predictors that determine disease progression and lung function deterioration in COPD patients. The research was conducted at N. Kipshidze Central University Clinic.

RISK FACTORS ASSOCIATED WITH THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

The purpose of the study was to reveal possible predictors that are associated with progression of chronic obstructive pulmonary disease (COPD) and deterioration of lung function in COPD patients. The research was conducted at N. Kipshidze Central University Clinic.

Physiologic and pathologic septal deviations: subjective and objective functional rhinologic findings.

Objective: A high incidence of septal deviation with significant inter-rater variability has been reported. An explanation could be the presence of physiological septal deviation besides pathological ones. We differentiated an unselected cohort by their nasal resistance into groups with physiological normal and pathologically increased resistance to detect differences and analogies in comparison to healthy subjects and a pathological cohort.

Biological osteosynthesis as the treatment mode for multifragmental extra-articular fractures of lower limb long bones.

The concept of stable-rigid osteosynthesis developed by AO ASIF was subjected to basical changes recently, with regard to the treatment strategy of multifragmental extra-articular fractures. The principle of biological osteosynthesis was worked out, which, in contrast to AO original concept, implies the indirect (closed) reduction and "bridge-like" (elastic) fixation, without intervening on fracture area, and additionally, with maximally preserved vascularization of intermediate fragments. The study objective implied the consideration and analysis of the results of biological osteosynthesis, performed on multifragmental extra-articular fractures of lower limb long tubular bones, also to determine the indications and advantages of different methods of biological osteosynthesis.

A case of osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm.

A 34-year-old, previously healthy female presented with severe acute upper quadrant abdominal pain and an 11-cm cystic mass in the tail of the pancreas. The patient underwent distal pancreatectomy with total gross excision of the mass. Grossly, the mass consisted of a multiloculated cystic lesion measuring 11.