Mechanisms for vascular effects of androgens in normotensive and hypertensive rats.

Castration had no effect on baseline BP and vascular sensitivity to acetylcholine and deficiency of nitric oxide and prostacyclin in normotensive specimens. Castration of hypertensive specimens decreased BP and potentiated the hypotensive effects of acetylcholine, but did not modulate vascular sensitivity to the blockade of nitric oxide and prostacyclin synthesis. The removal of the testicles abolished the pressor influence of glybenclamide in hypertensive and, particularly, in normotensive males.

Vascular and cardiac effects of stress in albino rats of different sex and age groups.

Stress exposure induced similar cardiac effects in male and female infantile rats, but vascular reactions to stress in males were more pronounced than in females. In mature male rats (but not in females), both cardiac and vascular responses to stress decreased in comparison with infantile animals. In adult rats, cardiac effects of stress were more pronounced than the vascular response; females demonstrated greater cardiac response and less significant vascular reactions than males.

Compounds of the 1,5-di(4-R-phenyl)- 3-selenopentanediones-1,5 series interaction with the basidiomycete Lentinula edodes lectins: computations and experiment.

The role of spatial and electron structure, hydrophobic properties and concentration of organoselenium compounds on their interaction with fungal metabolites--extracellular lectins of Lentinula edodes (shiitake mushroom) has been considered. By the hybrid method of density functional theory at the B3LYP/6-31G(d,p) theory level, spatial and electronic structure of the 1,5-diphenyl-3-selenopentanedione-1,5 (preparation DAPS-25), 1,5-di(4-methoxyphenyl)-3-selenopentanedione-1,5 and 1,5-di(4-ethoxyphenyl)-3-selenopentanedione-1,5 molecules has been studied. The above molecules have been stated to be substantially similar to each other by their electronic and spatial characteristics.

Effect of age and sex on blood pressure, development of renal hypertension, and concentration of nitric oxide in the blood of albino rats.

The mean blood pressure did not depend on the sex of animals and was characterized by the same ontogenetic changes in males and females. The mean blood pressure in infantile and, particularly, in old rats was higher than in adult animals. The increase in blood pressure in old rats was accompanied by a decrease in NO production.

Sex-related differences in nitric oxide content in healthy and hypertensive rats at rest and under stress conditions.

Immobilization was followed by an increase in blood NO concentration in male and female rats. After renovascular hypertension modeling blood pressure was higher and the decrease in nitric oxide concentration was more pronounced in males than in females. The levels of nitric oxide in healthy and hypertensive females at rest and during stress were higher than in males.

Investigation of blood flow microcirculation by diffusing wave spectroscopy.

This article presents a technique and a setup for noninvasive in vivo studies of cutaneous microcirculation. The technique is based on the analysis of intensity fluctuations of scattered coherent light. The analysis is made in terms of diffusing wave spectroscopy.