[Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis].

Purpose: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.

Materials And Methods: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR).

Immunohistochemistry, fluorescence in situ hybridization, and reverse transcription-polymerase chain reaction for the detection of anaplastic lymphoma kinase gene rearrangements in patients with non-small cell lung cancer: potential advantages and methodologic pitfalls.

Context: Echinoderm microtubule-associated protein-like 4 gene (EML4) and anaplastic lymphoma kinase gene (ALK) fusion was shown to be the driver of tumorigenesis in approximately 3% to 5% of patients with non-small cell lung cancer (NSCLC) and is associated with response to inhibition with crizotinib. However, no complete agreement regarding the best diagnostic test for identification of ALK rearrangements has been achieved yet.

Objective: To investigate the concordance, sensitivity, and specificity of immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and reverse transcription-polymerase chain reaction (RT-PCR) for detection of ALK rearrangements.

[Typical atrial flutter: classification, clinical manifestations, diagnosis, and treatment].

Main etiological factors, mechanisms of arrhythmogenesis and classification of atrial flutter (AFl) are presented. Clinical electrocardiographical and electrophysiological features of typical AFl are described. Main diagnostic measures are delineated and principles of tactical approach to management of patients with typical AFl presented.

[Remote clinical results of treatment of atrioventricular nodal reciprocated with the use of novel and traditional methods of radiofrequency catheter ablation of slow part pathway of atrioventricular junction].

Remote results of radiofrequency catheter ablation (RFCA) - modification of "slow" part pathway of atrioventricular junction (AVJ) in patients with typical form of atrioventricular nodal reciprocal reciprocated tachycardia (AVNRT), carried out on the basis bi and monopolar recording of electrical activity of fibers of slow" part pathway of AVJ. Study participants were 104 patients (44 women) aged 21-86 years with typical form of AVNRT who had been subjected to primary RFCA procedure - modification of slow part pathway of AVJ. In group 1 (n=51) RCA RFCA was conducted on the basis of simultaneous monoand bipolar endocardial registration recording of new potential of "slow" part pathway of AVJ.

[Nonischemic ventricular arrhythmias: classification, clinical manifestations, diagnosis, and treatment].

Clinico-electrocardiographical and electrophysiological features of noncoronarygenic ventricular arrhythmias are presented. Characteristics of localization of arrhythmogenic focus in various parts of left and right ventricular myocardium, in interventricular septum, and in immediate vicinity of each of 4 valves are discussed. Spectrum of necessary diagnostic measures is delineated, and assessment of efficacy of drug therapy is given.

[First in Russia experience of radiofrequency ablation with the help of robotic system of magnetic navigation on the occasion of heart rhythm disturbances].

We present first in Russia experience of interventional treatment of 15 patients (11 men, 4 women, mean age 34.2 +/- 13.9 years) in whom operations of endocardial electrophysiological study (endoEPS) and radiofrequency ablation (RFA) with the help of robotic system of magnetic navigation were carried out because of various disturbances of cardiac rhythm.