Nontuberculous Mycobacterial Pulmonary Infection Among Lung Transplant Recipients.

Objectives: Data are limited regarding the clinical significance of nontuberculous mycobacteria pulmonary infections among lung transplant recipients. We investigated the incidence and characteristics of pulmonary nontuberculous mycobacteria infection in ourlung transplant patient population.

Materials And Methods: We obtaineddata of the patients who underwent lung transplant in our center from January 1997 to March 2019.

Spondylitis following bloodstream dissemination of disseminated in an immunocompetent patient: a case report and literature review.

Non-tuberculous mycobacterial spondylitis is a rare spinal infection, especially among patients without acquired immunodeficiency syndrome or other immune impairments. Because of its rarity and non-specific clinical manifestations, diagnosis is often delayed or missed. Here, we present a case of spondylitis in an immunocompetent patient and review the relevant literature.

Continued Upward Trend in Non-Tuberculous Mycobacteria Isolation over 13 Years in a Tertiary Care Hospital in Korea.

Purpose: Despite decreased prevalence of tuberculosis, the incidence of the diseases associated with nontuberculous mycobacteria (NTM) has been increasing in South Korea and around the world. The present retrospective study was conducted to determine longitudinal changes in the epidemiology and distribution of NTM over 13 years at a tertiary care hospital in Korea.

Materials And Methods: We retrospectively analyzed data on species over 13 years (January 2007 to December 2019) by utilizing the laboratory information system.

Threat in water for drinking and domestic use: Nontuberculous mycobacteria.

Objective: Nontuberculous mycobacteria (NTM) have been recognized as a diverse group of organisms that are ubiquitous in environmental sources. In most regions of the world, NTM are not reportable as a public health disease, so epidemiological data are not easily available. However, data in published studies note increasing trends at the rate of NTM isolation from different geographic regions of the world.

Skin and soft-tissue infections due to rapidly growing mycobacteria: An overview.

Background: Rapidly growing mycobacteria (RGM) are increasingly being recognized as potential pathogens. RGM, particularly Mycobacterium abscessus, Mycobacterium fortuitum, and Mycobacterium chelonae, have been observed in both pulmonary and extrapulmonary infections including cutaneous, soft-tissue, and wound infections. However, there are limited reports of these potential pathogens from skin and soft-tissue infections.

Clinical course of peritoneal dialysis-related peritonitis due to non-tuberculosis mycobacterium - A single centre experience spanning 20 years.

Background: Peritoneal dialysis (PD)-related peritonitis caused by non-tuberculous mycobacteria (NTM) are difficult to diagnose, is associated with significant morbidity and mortality, and clinical course remains unclear. We determined the prevalence and clinical course of peritonitis caused by these organisms through our kidney registry over 20-year period.

Method: We reviewed all patients with NTM peritonitis identified in our tertiary centre between July 2000 and July 2020.

[Clinical behavior of infection and disease caused by non-tuberculous mycobacteria in Latin America: Scoping review].

Reports of infection and/or disease caused by non-tuberculous mycobacteria (NTM) are becoming increasingly frequent. This scope review describes the epidemiological and clinical trend of infection/disease caused by NTM in Latin America. OVID MEDLINE, Embase and LILACS databases were explored for relevant articles.

Disseminated infection with Hughes-Stovin syndrome.

usually causes localized cutaneous infections and abscesses but has the potential to cause disseminated infections, especially in immunocompromised hosts. We report a 27-year-old man with Hughes-Stovin syndrome and catastrophic antiphospholipid syndrome who was on chronic immunosuppressant therapy and developed disseminated infection. To the best of our knowledge, this is the first case report of infection in a patient with Hughes-Stovin syndrome.

Identification of Nontuberculous Mycobacteria in Drinking Water in Cali, Colombia.

Nontuberculous mycobacteria (NTM) are ubiquitous microorganisms naturally resistant to antibiotics and disinfectants that can colonize drinking water supply systems. Information regarding the spread of NTM in specifically South America and Colombia is limited. We aimed to identify and characterize NTM present in tap water samples from Cali, Colombia.

Microbial diversity of molasses containing tobacco (Maassel) unveils contamination with many human pathogens.

Objective: Tobacco smoking remains a worldwide health issue, and the use of flavored varieties (maassel) embedded in glycerine, molasses, and fruit essence via shisha paraphernalia (waterpipe) is growing globally. 16S rRNA gene pyrosequencing was conducted on 18 different varieties representing 16 flavors and three brands in order to study the microbiota of maassel and find whether it contains pathogenic bacteria.

Materials And Methods: The samples were selected randomly from the most utilized brands within Albaha, Saudi Arabia as determined through a questionnaire of 253 smokers.

Prolonged tedizolid use in cutaneous non-tuberculous mycobacterial infection.

Cutaneous non-tuberculous mycobacterial (NTM) infections are an emerging infectious disease and require a protracted course of combination antibiotics. Antimicrobial choice is limited by resistance and toxicity. Tedizolid is a new oxazolidinone antibiotic with activity against some NTM, but its use in the management of extrapulmonary NTM has not been described.

Prevalence of non tuberculous mycobacterial infection in surgical site infections and their antibiotic susceptibility profile.

Background: Surgical site infections (SSIs) are one of the leading causes of hospital-acquired infections contributing to about 20% of all cases, thereby causing an increase in morbidity and financial burden. Causative organisms associated with SSIs have not changed greatly over the last 10-15 years; however, the proportions of different types of causative organisms have changed with an increase in case reports of rare organisms such as non-tuberculous mycobacteria (NTM).

Methods: Samples received from patients with SSI were simultaneously cultured for the isolation of NTM along with routine bacteriological examination.

When Should Statins Be Stopped?

Unlabelled: is a non-tuberculous mycobacterium that can cause skin infections in immunocompetent individuals. We report a case of skin infection by this agent in a woman with dyslipidaemia, that culminated in statin-induced rhabdomyolysis due to the combination of clarithromycin, ciprofloxacin and simvastatin.

Learning Points: Skin infection with is an increasing global problem among immunocompetent individuals.

Invasive Outbreak at a Pediatric Dental Clinic.

Background: species, specifically and (MABs), are known to contaminate water systems and are uncommon causes of health care-associated infection, but morbidity can be significant and treatment complex.

Methods: Odontogenic MAB infections occurred in patients following pulpotomy procedures at dental clinic A from 1 January to 6 September 2016. We identified confirmed and probable cases using culture data, imaging, pathology results, and surgical findings.

Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages.

Background: The global rise in the incidence of non-tuberculosis mycobacterial infections is of increasing concern due their high levels of intrinsic antibiotic resistance. Although integrated viral genomes, called prophage, are linked to increased antibiotic resistance in some bacterial species, we know little of their role in mycobacterial drug resistance.

Results: We present here for the first time, evidence of increased antibiotic resistance and expression of intrinsic antibiotic resistance genes in a strain of Mycobacterium chelonae carrying prophage.

Endogenous Endophthalmitis in a Person Addicted to Intravenous Drugs Presenting as an Intraretinal Peripapillary Granuloma With Tractional Retinal Detachment.

Purpose: To report a case of endogenous endophthalmitis in a 28-year-old man with recent intravenous drug use that presented as an intraretinal peripapillary granuloma extending from the optic nerve head with an associated macular tractional retinal detachment.

Methods: Case report.

Results: Anterior chamber tap yielded aqueous cultures positive for .

Combining comparative genomic analysis with machine learning reveals some promising diagnostic markers to identify five common pathogenic non-tuberculous mycobacteria.

Non-tuberculous mycobacteria (NTM) can cause various respiratory diseases and even death in severe cases, and its incidence has increased rapidly worldwide. To date, it's difficult to use routine diagnostic methods and strain identification to precisely diagnose various types of NTM infections. We combined systematic comparative genomics with machine learning to select new diagnostic markers for precisely identifying five common pathogenic NTMs (Mycobacterium kansasii, Mycobacterium avium, Mycobacterium intracellular, Mycobacterium chelonae, Mycobacterium abscessus).

Investigation of two cases of Mycobacterium chelonae infection in haemato-oncology patients using whole-genome sequencing and a potential link to the hospital water supply.

Background: Haemato-oncology patients are at increased risk of infection from atypical mycobacteria such as Mycobacterium chelonae which are commonly found in both domestic and hospital water systems.

Aims: To describe the investigation and control measures following two patient cases of M. chelonae and positive water samples in the study hospital.

Non-tuberculous mycobacteria: a disease beyond TB and preparedness in India.

Background And Methods: Fifty-six Indian studies on NTM diseases were selected between 1981 and 2020 from various electronic databases (PubMed, EMBASE, Medline, BIOSIS preview, and Scopus) for systematic review.

Results: NTM isolation rates increased from 0.9% between 2001 and 2010 to 1.

Heater-Cooler Devices and Risk of Contamination during Cardiac Surgery.

Background:  Heater-cooler devices (HCD) have been implicated in a cardiosurgical contamination scenario causing prosthetic valve endocarditis.

Aim:  We characterized contamination of new HCDs and assessed the risk of intraoperative microorganism transmission from the HCD to the operating field.

Methods:  We initially acquired four new FlexTherm and then four new Maquet HCU40 HCDs and assessed occurrence and speed of microbial contamination (including mycobacteria) assessing swab and water samples from the device.

A case of infantile exogenous lipoid pneumonia with an unusual complication managed by modified whole lung lavage.

Exogenous lipoid pneumonia (ELP) is a known complication of lipid administration through either the nasal or oral route. ELP in paediatric patients is usually managed by discontinuing lipid administration and supportive care, including respiratory support and the use of antibiotics for secondary bacterial infection. The other modalities that remain controversial include the use of corticosteroids and clearing lipids by whole lung lavage.

General characteristics, features of cultivation and antibiotic resistance representatives of mycobacterium fortuitum group representatives (review of literature).

Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M.