1,624 results match your criteria: "Mycobacterium Chelonae"

Meagre () is one of the fast-growing species considered for sustainable aquaculture development along the Mediterranean and Eastern Atlantic coasts. The emergence of Systemic Granulomatosis (SG), a disease marked by multiple granulomas in various tissues, poses a significant challenge in meagre aquaculture. In the current study, we investigate the association of spp.

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Mycobacterium chelonae cutaneous infections unrelated to invasive procedures: A multicentre retrospective case series.

J Eur Acad Dermatol Venereol

December 2024

Gridist, Groupe Infectiologie Dermatologique - Infections Sexuellement Transmissibles, Société Française, de Dermatologie, Paris, France.

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Background: Non-tuberculous mycobacterial (NTM) pulmonary disease (PD) is a significant concern in China, compounding the existing burden of TB. This review aims to summarise the treatment outcomes for NTM-PD in China.

Methods: We reviewed the evidence on NTM-PD, including treatment regimens and clinical outcomes, from 17 studies identified through screening of three Chinese biomedical databases.

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Background: Infective endocarditis (IE) due to nontuberculous mycobacteria (NTM) is a rare infection, and several outbreaks have been reported in the last 2 decades. However, the clinical spectrum is still poorly understood. This systematic review aimed to evaluate the clinical characteristics and outcomes in NTM IE.

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Background: Driveline infections (DLI) caused by nontuberculous mycobacteria (NTM) in patients with implantable left ventricular assist devices (iLVAD) are rare but fatal, requiring early diagnosis and appropriate treatment. Herein, we present a rare case of DLI caused by Mycobacterium chelonae, which was promptly diagnosed using Gram stain and Ziehl-Neelsen stain and followed a favorable clinical course.

Case Presentation: A 51-year-old man with an iLVAD complicated by DLI was admitted to our center.

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Hand infection caused by atypical mycobacteria is an uncommon condition. We present a case of hand infection caused by in a patient who had undergone acupuncture. The clinical features, treatment, and outcome are described.

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Article Synopsis
  • * A systematic review of 335 cases revealed that Mycobacterium abscessus was the most frequently identified pathogen, with many patients receiving treatment using multiple antibiotics.
  • * Early diagnosis using acid-fast bacilli staining and culture is crucial, and catheter removal may be necessary for effective management of these NTM infections.
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  • A 36-year-old woman with a history of congenital hydrocephalus experienced complications from her VP shunt, including an infected abdominal incision with no recent infection risks other than a minor gynecological procedure.
  • Cultures revealed unusual bacteria, leading to the externalization and eventual removal of her shunt, alongside a course of intravenous and oral antibiotics, which successfully healed the infection.
  • The case highlights the need for thorough investigation of infections in shunt patients, even when they present atypically or outside the standard timeframe for infections.
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Endocarditis associated with contamination of cardiovascular bioprostheses with Mycobacterium chelonae: a collaborative microbiological study.

Lancet Microbe

December 2024

Institute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany; MoKi Analytics, Berlin, Germany; Moter Diagnostics, Berlin, Germany. Electronic address:

Background: Mycobacterium chelonae is a rare cause of infective endocarditis that is difficult to diagnose and treat. After we found M chelonae in a series of patients, we aimed to investigate its role in cardiovascular prosthesis dysfunction and contamination of bioprostheses as a possible cause of infection.

Methods: In this collaborative microbiological study, we report on nine patients treated in three cardiovascular surgical departments in Germany, who were found to have M chelonae infection after receiving BioIntegral bioprostheses.

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Introduction: With a projected mortality toll of 1.4 million in 2019, tuberculosis (TB) continues to be a significant public health concern around the world. Studies of novel treatments are required due to decreased bioavailability, increased toxicity, increased side effects, and resistance of several first- and second-line TB therapies, including isoniazid and ethionamide.

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Duplex recombinase aided amplification-lateral flow dipstick assay for rapid distinction of and .

Front Cell Infect Microbiol

October 2024

Department of Medical Microbiology, School of Basic Medicine, Shandong Second Medical University, Weifang, Shandong, China.

Objectives: This study aims to develop a novel diagnostic approach using the recombinase aided amplification-lateral flow dipstick(RAA-LFD) assay for the distinction of (MTB) and (MAC), enabling rapid and convenient as well as accurate identification of them in clinical samples.

Methods: Our study established a duplex RAA-LFD assay capable of discriminating between MTB and MAC. Based on the principles of RAA primer and probe design, specific primers and probes were developed targeting the MTB and the MAC separately.

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Article Synopsis
  • The study monitored 29 Maquet heater-cooler units (HCUs) over a 63-month period to track the presence of non-tuberculous mycobacteria (NTM) in response to the replacement of LivaNova devices due to contamination concerns.
  • Results showed a significant increase in NTM positivity, particularly after three years, with 100% of HCU40 and 62% of HU35 devices colonized, primarily by Mycobacterium gordonae.
  • The findings indicate that current disinfection methods using chloramine-T are insufficient, highlighting the need for improved device safety designs and new disinfection protocols.
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Non-tuberculous mycobacterium (NTM) infection can cause a broad range of pathology, especially in an immunocompromised patient. We report a case of ascending lower extremity nodules in a renal transplant patient that were found to be caused by , an NTM. We discuss the clinical evaluation and workup of this patient and why NTM infections may require a high degree of clinical suspicion to properly diagnose and treat.

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Background: Tuberculosis in cattle is caused by Mycobacterium tuberculosis complex (MTBC) species. Apart from MTBC, different Nontuberculous Mycobacteria (NTM) species have also been isolated from cattle. The presence of NTM infection in bovines makes the diagnosis of bovine tuberculosis (bTB) a cumbersome task.

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Article Synopsis
  • - This study focuses on the genomic analysis of six isolates of rapidly growing non-tuberculous mycobacteria from Siamese fighting fish, which were previously characterized through other methods like antibiotic susceptibility and virulence testing.
  • - Initial identification using 16S rRNA sequencing suggested they belonged to five species, but further whole genome sequencing and genomic comparisons led to reclassification, revealing a potential new species for one isolate.
  • - The study highlights the presence of common virulence genes in all isolates and notes the horizontal gene transfer of specific traits from environmental bacteria, emphasizing the importance of whole genome sequencing for accurate mycobacterial classification.
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The Intriguing Pattern of Nontuberculous Mycobacteria in Bulgaria and Description of sp. nov.

Int J Mol Sci

September 2024

National Reference Laboratory of Tuberculosis, Department of Microbiology, National Center of Infectious and Parasitic Diseases, 44A General Nikolai Stoletov Boulevard, 1233 Sofia, Bulgaria.

We investigated the rise of nontuberculous mycobacteria (NTM) infections in Bulgaria, focusing on species identification and distribution from 2018 to 2022. Utilizing advanced diagnostic tools, including the Hain Mycobacterium CM/AS method, Myco-biochip assay, and whole-genome sequencing, the study identifies and characterizes a diverse range of species from clinical samples. While , , , and were dominating, a number of rare species were also found.

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Successful treatment of Keratitis caused by Mycobacterium chelonae and an overview of previous cases in Europe.

Ann Clin Microbiol Antimicrob

October 2024

Institute of Clinical Microbiology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Article Synopsis
  • A case study reports a 70-year-old woman developed keratitis caused by Mycobacterium chelonae after cataract surgery, showcasing the challenges in diagnosing nontuberculous mycobacterial infections.
  • Initial tests failed to identify a pathogen, but repeated testing revealed M. chelonae, leading to a change in treatment to a combination of antibiotics.
  • Successful combination therapy stabilized the infection, but corneal transplantation was ultimately necessary for visual rehabilitation due to scarring.
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Background: Tuberculous pleurisy (TP) is one of the most common types of extrapulmonary tuberculosis, often secondary to tuberculosis (TB). Clinical and imaging manifestations of non-tuberculous mycobacterial pulmonary diseases (NTM-PD) are usually similar to those of tuberculosis. Because of their similarity and the high incidence of tuberculosis, non-tuberculous mycobacterial infections are often overlooked for a long time.

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Article Synopsis
  • - The study focuses on the molecular characteristics of non-tuberculous mycobacteria (NTM) that can cause infections outside of the lungs, detailing a collection of 45 extrapulmonary isolates over a span of six months from various sites.
  • - Key findings revealed that the most frequently isolated species were Mycobacterium avium, Mycobacterium chelonae, and Mycobacterium fortuitum, with significant variations in sequence types and the presence of antimicrobial resistance genes in some isolates.
  • - The research emphasizes the need for ongoing surveillance to monitor the prevalence and resistance patterns of NTM, helping to identify emerging strains and improve understanding of their virulence factors.
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Cutaneous infections caused by Mycobacterium chelonae can present with a variety of clinical symptoms, depending on the patient's immune status. Here, we report a case involving a 46-year-old woman with multiple sclerosis who developed a cutaneous infection caused by M. chelonae.

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Distribution of nontuberculous mycobacteria in dental unit waterlines: A potential health hazard in the dental office.

Microb Pathog

November 2024

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: It is essential to control the microbiology of dental unit water lines (DUWs) to prevent the spread of nontuberculous mycobacteria (NTM) and associated oral diseases. Therefore, the objective of this study was to quantify the presence of NTM in the water of 112 DUWs from dental centers and 57 DUWs from individual dental offices in Tehran, Iran.

Methods: A total of 169 water samples were collected from DUWs.

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Article Synopsis
  • A recent study focused on two kidney transplant patients who developed infections caused by a rapidly growing non-tuberous mycobacteria, leading to skin lesions and disseminated infections.
  • Both patients were on immunosuppressive medications post-transplant and exhibited different treatment regimens, including varying doses of prednisolone and other drugs.
  • Successful treatment involved prompt antibiotic therapy with a combination of clarithromycin, azithromycin, linezolid, and tigecycline, highlighting the effectiveness of long-term use of clarithromycin and azithromycin in such cases.
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  • This study investigates the characteristics and treatment outcomes of patients with non-tuberculous mycobacteria (NTM) diseases at a hospital in Catania, Italy, focusing on demographics and treatment effectiveness.
  • The research involved a retrospective analysis of 10 diagnosed patients from 2019 to 2021, collecting data on their demographics, comorbidities, treatment methods, and outcomes using descriptive statistics.
  • Results showed that all patients were female with a median age of 55.44 years, predominantly affected by pulmonary diseases; despite all achieving microbiological cures, 60% showed clinical improvement, highlighting the need for tailored treatment strategies and further research on NTM management.
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Increasing trends of non-tuberculous mycobacteria clinical isolates in Guangzhou, China.

Acta Trop

December 2024

State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Department of Tuberculosis, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, Guangdong 510095, PR China. Electronic address:

Non-tuberculous mycobacteria (NTM) are one of major public health concern. The current study aimed to find the prevalence trends of NTM in Guangzhou, China from January 2018 to December 2023. A total of 26,716 positive mycobacterial cultures were collected.

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