657 results match your criteria: "Myasthenia Gravis and Pregnancy"

Introduction: The course of double-seronegative myasthenia gravis (DSNMG) during and after pregnancy has not been well described.

Objective: To assess the course of DSNMG during pregnancy and within 6 months postpartum.

Methods: A retrospective cohort study of women with DSNMG seen in the Duke Myasthenia gravis (MG) Clinic after 2003.

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Prenatal diagnosis of isolated bilateral clubfoot: Is amniocentesis indicated?

Acta Obstet Gynecol Scand

January 2024

Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Paris, France.

Article Synopsis
  • This study evaluates the effectiveness of cytogenetic testing through amniocentesis in fetuses diagnosed with isolated bilateral talipes equinovarus after an ultrasound.
  • It involved a retrospective analysis of 214 cases, where various prenatal data and outcomes were tracked from five fetal medicine centers between 2012 and 2021.
  • The results indicated that the majority of cases had normal genetic outcomes, with a high live birth rate, but three medical terminations occurred due to significant genetic disorders detected through testing.
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Article Synopsis
  • FARAD is a rare condition affecting newborns of mothers with myasthenia gravis, caused by maternal antibodies targeting fetal AChRs, with only two documented cases from asymptomatic mothers.
  • A case study reports an asymptomatic mother with two FARAD children; the first child required significant medical intervention for severe symptoms, while the second child benefitted from preventive IVIG therapy during pregnancy and had a better outcome.
  • Findings suggest FARAD should be considered when diagnosing congenital neuromuscular disorders, and that prenatal IVIG treatment may improve health results for affected newborns.
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Background And Purpose: Few large-scale studies examine whether maternal myasthenia gravis (MG) is a risk factor for complications during pregnancy and childbirth. This study evaluated whether maternal MG is associated with an increased risk of adverse pregnancy, delivery, and neonatal outcomes.

Methods: We conducted a nationwide Swedish register-based cohort study of women who gave birth to singleton infants (≥22 gestational weeks) during 1987-2019.

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This review aimed to evaluate the mechanism of premature cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients, particularly in the female population, and emphasize the need for early management interventions; explore the association between SLE and two autoimmune diseases, myasthenia gravis (MG) and antiphospholipid antibody syndrome (APS), and their management strategies; and evaluate the effectiveness of pharmacological and non-pharmacological interventions in managing SLE, focusing on premenopausal females, females of childbearing age, and pregnant patients. We conducted a comprehensive literature review to achieve these objectives using various databases, including PubMed, Google Scholar, and Cochrane. The collected data were analyzed and synthesized to provide an evidence-based overview of SLE, its management strategies as an independent disease, and some disease associations.

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Myasthenia gravis (MG) is an autoimmune disease affecting young women in their second and third decades, coinciding with their reproductive years. We aim to explore the choices and challenges in the treatment of MG in pregnancy. Cochrane, PubMed, Google Scholar, and Embase were the four databases systematically searched for studies with patients reporting pregnancy outcomes for women with MG during pregnancy using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) technique.

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Transient Neonatal Myasthenia Gravis: A Case Report.

Pril (Makedon Akad Nauk Umet Odd Med Nauki)

July 2023

1PJU University Clinic for Gynecology and Obstetrics, Faculty of Medicine, University "St. Cyril and Methodius", Skopje.

Transient neonatal myasthenia gravis (TNMG) is a neuromuscular disorder that occurs in infants born from mothers with myasthenia gravis (MG) due to transplacental transfer of antibodies against the acetylcholine receptor. TNMG is a rare form occurring in 10-15% of infants born from mothers with MG. We present a case of a newborn with TNMG with generalized hypotonia and respiratory distress.

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Article Synopsis
  • In utero exposure to maternal antibodies against fetal acetylcholine receptors can cause severe conditions like arthrogryposis multiplex congenita (AMC) and the milder fetal acetylcholine receptor inactivation syndrome (FARIS), but the full impact remains unclear.
  • A study of 46 cases reveals that many affected mothers did not have prior diagnoses of myasthenia gravis, suggesting underreporting and missed preventative measures.
  • Among the findings, significant long-term effects in surviving infants included various physical weaknesses, respiratory issues, and unexpected conditions like hearing loss; treatment with oral salbutamol showed promising improvement in symptoms for many children.
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Introduction/aims: Myasthenia gravis (MG) with muscle-specific tyrosine kinase (MuSK) antibodies (MMG) is predominantly seen in women of childbearing age. Our objective in this study was to describe the course of MMG during pregnancy and within 6 months postpartum, and to document any effect on fetal health.

Methods: A retrospective review was performed of medical records of patients with MMG seen in the Duke Myasthenia Gravis Clinic from 2003 to 2022.

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Myasthenia gravis (MG) is an acquired autoimmune disorder of the neuromuscular junction with an annual incidence rate of 2 to 21 per million. A 25-year-old primiparous woman with no significant medical history presented for a routine antenatal appointment at 37 weeks of gestation. She reported a two-week history of transient diplopia and a five-month history of fluctuating weakness in her proximal limbs.

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Treatment considerations in myasthenia gravis for the pregnant patient.

Expert Rev Neurother

February 2023

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Introduction: Myasthenia gravis (MG) is an autoimmune disease where muscle antibodies form against the acetylcholine receptor (AChR), MuSK, or LRP4 at the neuromuscular junction leading to weakness. Patients worry about consequences for pregnancy, giving birth, nursing, and child outcome.

Areas Covered: This review lists the pharmacological treatments for MG in the reproductive age and gives recommendations.

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Incidence of Facial Nerve Palsy in Pregnancy.

Cureus

November 2022

Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.

The facial nerve is cranial nerve number seven. A facial nerve palsy is a form of severe weakness of muscles of the face or paralysis due to swelling or any other kind of injury to the seventh nerve. Bell's palsy is the most common reason for facial nerve palsy in both pregnant and non-pregnant women, as well as in men and children.

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Problem: Myasthenia gravis (MG), an autoimmune neuromuscular disease affecting women of childbearing age, exerts an impact on pregnancy, and vice versa. The purposes of the study were to evaluate adverse pregnancy outcomes and postpartum exacerbation in a cohort of Asian MG women, and to explore the predictors for these outcomes.

Methods Of Study: Thirty-seven MG pregnancies of 33 women followed in Xiangya and the second Xiangya hospitals between January 2012 and January 2022, were included in this study.

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Introduction: Myasthenia gravis is characterized by skeletal muscle weakness, the most common initial presentation includes ocular weakness with asymmetric ptosis and binocular diplopia. Around 19-50% of pregnant women with myasthenia gravis will experience a worsening of the disease. The objective of this article was to review the current information regarding the interrelation between MG and pregnancy; as well as its approach.

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Myasthenia gravis in pregnancy: Systematic review and case series.

Obstet Med

June 2022

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Canada.

Background: Myasthenia gravis is an autoimmune disease which can impact pregnancy.

Methods: Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included studies.

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What is in the Neuromuscular Junction Literature?

J Clin Neuromuscul Dis

June 2022

Departments of Neurology and.

Article Synopsis
  • This update discusses recent advancements in treatments for myasthenia gravis, including the FDA approval of the Fc receptor inhibitor efgartigimod.
  • It highlights risks and considerations related to corticosteroid use, such as treatment initiation and tapering, along with the implications of antibody overshoot after plasmapheresis.
  • Additionally, the update reviews the role of acetylcholine receptor antibodies in diagnosing ocular myasthenia, addresses concerns regarding myasthenia gravis during pregnancy, and examines case reports involving Lambert-Eaton myasthenic syndrome and its related conditions.
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Introduction: Neurological disorders in pregnancy may be observed in patients with a pre-existing neurological disorder; patients developing a primary neurological disorder during the course of pregnancy or puerperium; and in patients with primary medical disorders presenting with neurological manifestations.

Objectives: The objectives of the study were to find out the magnitude of neurological disorders in pregnancy in a tertiary care hospital along with assessment of proportion of women with particular disorders among total number of neurological disorders during the course of pregnancy or puerperium (6 weeks after child birth) and also to elicit the effect of neurological disorders on pregnancy outcome, if any.

Methods: A prospective observational longitudinal study was carried out in a tertiary care centre of Eastern India from July 2018 to June 2020 including all pregnant women attending the department of Obstetrics and Gynaecology.

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An Interesting Case of Fatal Myasthenic Crisis Probably Induced by the COVID-19 Vaccine.

Cureus

March 2022

Department of Oral and Maxillofacial Surgery, Oral Pathology and Oral Medicine, University of Nairobi, Nairobi, KEN.

A myasthenic crisis is a severe, life-threatening exacerbation of myasthenia gravis that causes a rapid onset of muscle weakness and fatigue that may result in tetraparesis, dyspnea, respiratory insufficiency, aspiration, and death. Bulbar muscle functions are markedly affected resulting in depressed cough reflex, swallowing, and speech. Thus, mechanical ventilation, supportive feeding, and critical care are essential for the survival of patients in a myasthenic crisis.

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Background: The loss of one or more pregnancies before viability (i.e. pregnancy loss or miscarriage), has been linked to an increased risk of diseases later in life such as myocardial infarction and stroke.

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Myasthenia gravis (MG) is an autoimmune disease that is characterised by the formation of antibodies against acetylcholine receptors in the postsynaptic membrane of the neuromuscular junction. The course of the disease cannot be predicted during pregnancy. A subtype of MG with positive muscle-specific receptor tyrosine kinase (anti-MuSK) antibodies exhibits more localised clinical characteristics and a poor response to treatment compared with the disease subtype that involves positivity for acetylcholine receptor antibodies.

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A 16-year-old primigravida was diagnosed with COVID-19 in her second trimester. She decompensated quickly and had to be admitted to hospital and intubated. She was diagnosed with a fetal demise after being intubated and neurology suspected myasthenia gravis due to neurologic symptoms.

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Risk factors for pregnancy-related clinical outcome in myasthenia gravis: a systemic review and meta-analysis.

Orphanet J Rare Dis

February 2022

Huashan Rare Disease Center, Department of Neurology, Huashan Hospital, Fudan University, 200040, Shanghai, China.

Objective: Myasthenia gravis (MG) is an autoimmune disorder that frequently affects females at reproductive age. Herein, we aimed to assess the associations of clinical factors with pregnancy-related outcome in MG.

Methods: We searched PubMed and EMBASE for case-control and cohort studies that reported the MG status during or after pregnancy and relevant clinical variables.

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