657 results match your criteria: "Myasthenia Gravis and Pregnancy"

Nomogram for predicting pregnancy-related relapse of myasthenia gravis.

Orphanet J Rare Dis

December 2024

Huashan Rare Disease Centre and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Centre for Neurological Disorders, Fudan University, Shanghai, 200040, China.

Article Synopsis
  • Myasthenia gravis (MG) is an autoimmune condition affecting muscle control, and this study investigates its relapse risk during pregnancy to enhance clinical outcomes.
  • The study tracked 113 women with MG to identify factors influencing relapse and created a predictive model using data on relapse rates and treatments, revealing that a significant number of relapses occur particularly in the first trimester and postpartum.
  • Key findings indicate that younger age at delivery, less time with stable MG, presence of thymic hyperplasia, and inadequate treatment during pregnancy elevate the risk of relapse, highlighting crucial periods and factors for patient monitoring.
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Unlabelled: It is documented that maternal diseases or treatments influence a newborn's clinical status at birth. If a prenatal medical history is not available, or if signs or symptoms of a mother's disease are revealed for the first time during pregnancy or postpartum, their effects on the newborn may be misattributed.

Objective: The objective of this study is to emphasize the paramount importance of prenatal care, for both mothers and newborns, as a lack of maternal signs and symptoms during pregnancy does not exclude a potential severe neonatal condition.

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Neurologic disease in the obstetric patient.

Curr Opin Anaesthesiol

October 2024

Advocate Illinois Masonic Medical Center, Department of Anesthesiology, Chicago, Illinois, USA.

Article Synopsis
  • Neurologic problems can happen during pregnancy, but there aren’t many guidelines to help doctors, so this review shares new information about managing these issues.
  • Anesthesia methods are generally safe for pregnant women with certain neurological conditions, like multiple sclerosis, but doctors need to be careful because reactions can be unpredictable.
  • More research is needed, but existing studies are helping doctors understand how to best treat pregnant women with neurological disorders.
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Placental inflammatory injury induced by chlorinated polyfluorinated ether sulfonate (F-53B) through NLRP3 inflammasome activation.

Ecotoxicol Environ Saf

July 2024

Department of Reproductive Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address:

Article Synopsis
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Myasthenia gravis and pregnancy: Lessons learned from a complex a case report.

SAGE Open Med Case Rep

May 2024

Department of Gynecology-Obstetrics, Mohammed V Military University Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Article Synopsis
  • * The relationship between myasthenia gravis and pregnancy is complex, as pregnancy can influence the disease course, while the disease may impact the pregnancy and fetus.
  • * A case study of a 28-year-old woman with myasthenia gravis showed a disease relapse during her third trimester, highlighting the challenges of managing this condition in pregnant patients.
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Article Synopsis
  • * Rare instances of NMOSD co-existing with antiphospholipid syndrome have been reported, highlighting the necessity to consider multiple autoimmune disorders in a patient’s diagnosis due to the complexity of symptoms.
  • * In resource-limited settings, delayed diagnosis and treatment of NMOSD often worsen patient outcomes, as illustrated by a case study of an African woman who experienced significant neurological symptoms alongside antiphospholipid syndrome, emphasizing the need for personalized medical approaches
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Article Synopsis
  • - International guidelines for myasthenia gravis (MG) exist, but a group of Belgian experts provides tailored recommendations specifically for managing MG in Belgium, focusing on both generalized (gMG) and ocular myasthenia gravis (oMG).
  • - Treatment strategies are based on the efficacy of different therapies, their approval and reimbursement status in Belgium, everyday clinical practices, and the authors' personal experiences, reflecting the latest knowledge as of February 2024.
  • - The publication also covers important factors for MG management, including handling comorbidities, avoiding drugs that worsen symptoms, considerations for pregnant patients, vaccination, and a forward-looking perspective on potential new treatments in the future.
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Mycophenolate and methotrexate are better tolerated than azathioprine in myasthenia gravis.

Neuromuscul Disord

May 2024

Manchester Centre for Clinical Neuroscience, Northern Care Alliance NHS Foundation Trust, Salford Royal, Stott Lane, Salford, M6 8HD, UK; The University of Manchester, Manchester Academic Health Science Centre, Core Technology Facility, Manchester, M13 9WU, UK.

Article Synopsis
  • Azathioprine is the first choice medicine for treating myasthenia gravis, but many people also use mycophenolate and methotrexate as alternatives.
  • A survey of 235 people found that azathioprine caused liver problems in 23% of users, mycophenolate led to diarrhea in 14%, and methotrexate made 18% feel tired.
  • Women generally have more side effects from these medicines, and azathioprine is often stopped more often than the other two due to these side effects, showing there’s a need for better treatments.
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Myasthenia Gravis in Pregnancy and the Newborn.

Neoreviews

April 2024

Department of Obstetrics and Gynecology, University of Arizona Phoenix College of Medicine, Banner University Medical Center, Phoenix, AZ.

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Myasthenia Gravis in Pregnancy and the Newborn.

Neoreviews

April 2024

Department of Obstetrics and Gynecology, University of Arizona Phoenix College of Medicine, Banner University Medical Center, Phoenix, AZ.

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[Myasthenia gravis-Gender aspects and family planning].

Nervenarzt

April 2024

Department of Neurology, Neuroscience Clinical Research Center (NCRC) and Integrated Myasthenia Gravis Center, Charité - Universitätsmedizin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Article Synopsis
  • Gender differences can affect the diagnosis, treatment, and long-term outcomes of myasthenia gravis (MG), particularly since women are often diagnosed during childbearing years.
  • A literature review highlights that these differences include clinical factors and antibody status, with pregnancy generally being safe for MG patients and good outcomes expected for mothers and infants.
  • Close monitoring during pregnancy is crucial to quickly address any potential issues caused by maternal antibodies, emphasizing the need for thorough medical advice and teamwork among healthcare providers for patients planning to have children.
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Pregnancy in myasthenia gravis: a retrospective analysis of maternal and neonatal outcome from a large tertiary care centre in Germany.

Arch Gynecol Obstet

July 2024

Department of Neurology, Neuroscience Clinical Research Center (NCRC) and Integrated Myasthenia Gravis Center, Charité - Universitätsmedizin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Article Synopsis
  • Myasthenia gravis (MG) is an autoimmune disease that causes fluctuating muscle weakness, significantly impacting pregnant women and potentially affecting their newborns with conditions like transient neonatal myasthenia gravis (TNMG) and arthrogryposis multiplex congenita (AMC).
  • A study analyzed 66 pregnancies among women with MG, finding that 63% experienced worsening symptoms during pregnancy, but no patients had a myasthenic crisis and the need for acute treatment was low.
  • Overall, maternal and neonatal outcomes were positive, with normal rates of cesarean and slightly higher rates of operative vaginal delivery, providing valuable insights for healthcare providers advising MG patients who wish to have children.
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Article Synopsis
  • Myasthenic crisis (MC) causes severe muscle weakness, particularly affecting breathing, while Takotsubo cardiomyopathy (TC) is a rare heart condition often seen in postmenopausal women; this case involves a premenopausal woman experiencing both conditions.
  • A 31-year-old woman with hypothyroidism showed severe respiratory distress and an abnormal heart function, which improved significantly after treatment with IVIG.
  • The link between TC and MC is uncommon, but stressors like illness or surgery can trigger both conditions, highlighting the need for careful heart monitoring in MC patients to improve their outcomes.
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Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report.

Degener Neurol Neuromuscul Dis

March 2024

Department of Neonatology, Shenzhen Third People's Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, People's Republic of China.

Myasthenia gravis (MG) is an autoimmune disease which can impact pregnancy. We describe a transient neonatal myasthenia gravis (TNMG) born to an asymptomatic mother aged 26. The newborn presented cyanosis and generalized muscular weakness quickly after birth.

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Article Synopsis
  • * Symptoms of TNMG vary from minor feeding issues to severe respiratory problems, but most cases resolve naturally within weeks, with treatment options available if necessary.
  • * Awareness among healthcare professionals is crucial as TNMG can be unpredictable and may recur in siblings; certain preventive measures, like thymectomy and immunoglobulins, may help reduce risks.
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Article Synopsis
  • * A working group of MG experts from five Nordic countries created treatment guidance based on thorough literature reviews and discussions, identifying first-line and second-line therapies, including medications and surgical options.
  • * Treatment for MG often requires a combination of therapies, ongoing specialized care, and consideration of lifestyle adaptations, with recent developments in novel treatments and the importance of pregnancy planning for affected women.
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Article Synopsis
  • Myasthenia gravis (MG) is a rare autoimmune disease that significantly affects family planning, with many patients opting against parenthood due to the impact of their symptoms.
  • The study analyzed data from 1,660 MG patients, highlighting challenges related to pregnancy and raising children, along with the perceived need for social support, particularly in negotiations with health insurers and transportation to appointments.
  • Results indicated that a notable percentage of patients reported lower levels of social support, especially among those with moderate disease severity or medium incomes, emphasizing the importance of supportive networks for MG patients.
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Pregnancy planning may impact maternal and neonatal outcomes in people with myasthenia gravis.

Muscle Nerve

March 2024

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Accessible Care Pregnancy Clinic, Sunnybrook Health Sciences Centre, Toronto, Canada.

Article Synopsis
  • Myasthenia Gravis (MG) is an autoimmune disorder affecting young adults, and its management during pregnancy can influence both the mother and baby's health; this study aims to evaluate if planning a pregnancy can improve outcomes.
  • An online survey collected data from 156 participants with MG, revealing that a higher percentage of planned pregnancies resulted in fewer complications such as MG flare-ups and hospitalizations compared to unplanned pregnancies.
  • Results suggest that planning pregnancies might lower risks of exacerbation and hospital stays for mothers with MG, but more extensive studies are needed for confirmation and to identify other influencing factors.
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Safety and efficacy of immune checkpoint inhibitor cancer therapy in patients with preexisting type 1 diabetes mellitus.

Front Endocrinol (Lausanne)

December 2023

Division of Endocrinology, Department of Medicine, University of California, Los Angeles (UCLA) Geffen School of Medicine, Los Angeles, CA, United States.

Article Synopsis
  • Immune checkpoint inhibitors (ICI) are effective for many cancers but can cause serious side effects, particularly in patients with autoimmune diseases like type 1 diabetes mellitus (T1DM), who are often excluded from clinical trials.
  • A study analyzed the safety and outcomes of ICI in 11 cancer patients with preexisting T1DM, noting that most received anti-PD1 therapy and experienced some immune-related adverse events (IRAEs).
  • The findings indicated that while some patients had severe IRAEs requiring treatment interruptions, the overall risk of IRAEs in T1DM patients was similar to that in matched patients without T1DM.
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