4 results match your criteria: "Musculoskeletal University Center Munich (MUM) University Hospital[Affiliation]"

Purpose: If surgery is indicated for elderly patients suffering a proximal humerus fracture, reverse fracture arthroplasty became the preferred type of treatment due to its good and reliable outcomes over the last decade. Surgeons could choose from a wide range of implants and up to now there was no evaluation, if a change of the manufacturer affects patients` outcome.

Methods: The last 100 patients before and the first 100 after manufacturer change in reverse fracture arthroplasty were evaluated at a level one trauma center, all treated by only 3 senior shoulder surgeons.

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Background: Fragility fractures of the pelvis (FFP) in elderly patients are an increasing concern due to their association with osteoporosis and the aging population. These fractures significantly affect patients' mobility and quality of life. This study evaluates different surgical techniques in patients suffering from FFP to provide standardized recommendations for treatment strategies.

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A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons.

Nat Commun

August 2024

Univ. Lille, INSERM, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, Lille, France.

Article Synopsis
  • The arcuate nucleus (ARH) in the hypothalamus is crucial for energy balance, as it detects metabolic hormones in the blood, but only a few neurons in this area can sense these signals due to a barrier involving the median eminence (ME).
  • The study found that the proteoglycan aggrecan, produced by certain ARH neurons, establishes a diffusion gradient that limits the entry of these metabolic signals into the ARH, particularly during fasting when more aggrecan is deposited.
  • Disrupting aggrecan deposits allows more blood-borne molecules to enter the ARH, leading to uncontrolled food intake, highlighting the importance of this diffusion barrier in the brain's metabolism regulation.
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Article Synopsis
  • Since their introduction in Germany in 2019, e-scooters have gained popularity, leading to a noticeable increase in associated injuries, prompting this study to evaluate injury patterns in e-scooter accidents.
  • The study analyzed 271 patients treated in the emergency department from May 2019 to October 2022, revealing that traumatic brain injuries were the most common (38%), with upper limb fractures also prevalent, and 40 patients required surgical intervention.
  • The findings suggest that implementing measures like mandatory helmet use, stricter alcohol regulations, and designated riding times could greatly enhance e-scooter safety.
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