284 results match your criteria: "Murcia University.[Affiliation]"

Article Synopsis
  • Previous models for predicting weight gain haven't been very effective, leading researchers to explore both traditional environmental factors and genetic markers to enhance accuracy.* -
  • A study involving nearly 246,000 participants found that environmental factors provided good predictive ability for weight gain, while genetic models performed poorly, especially at mid-late adulthood.* -
  • The research suggests that environmental factors should be incorporated into prevention strategies, and that genetic factors may be more relevant in predicting weight gain earlier in life.*
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There is a gap in the literature on relationships between temperament, family functioning, and psychological well-being from a eudamonic perspective in emerging adulthood. To shed light on this issue, the aim of our study was to analyze the effect of temperament and family functioning profiles on psychological well-being in a sample of Spanish university students ( = 332). Results showed a positive association between the resilient temperament profile and psychological well-being, while the inverse relationship was observed for the non-desirable temperament profile.

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  • In 2023, Europe raised concerns about rising severe neonatal infections due to a new lineage of echovirus 11 (E11), prompting an analysis of E11 cases in Spain from 2019 to 2023.
  • Out of 1,288 samples, 103 were found to be E11-positive, but the detection rates and severity of infections among neonates did not significantly change after the new lineage appeared in June 2022.
  • The findings suggest that the new lineage 1 is not responsible for increased neonatal infections, but the discovery of novel E11 recombinants linked to severe cases highlights the need for better monitoring and surveillance.
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Landscape Heterogeneity Drives Genetic Diversity in the Highly Dispersive Moss Hedw.

Plants (Basel)

October 2024

Department of Plant Biology, Faculty of Biology, Murcia University, 30100 Murcia, Spain.

, a cosmopolitan moss species known for its remarkable dispersal capacity, was selected as the focal organism to investigate the relationship between landscape features and genetic diversity. Our study encompassed samples collected from two distinct regions: the Spanish Sierra Nevada Mountains (SN), characterized by a diverse landscape with an altitudinal difference of nearly 3500 m within a short distance, and the Murcia Region (MU) in Southeast Spain, characterized by a uniform landscape akin to the lowlands of Sierra Nevada. Genotyping analysis targeted three genetic regions: the nuclear ribosomal internal transcribed spacer (nrITS), the chloroplast 3-16 region, and the mitochondrial 5-16 spacer.

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Article Synopsis
  • * No significant associations were found between individual metabolites or patterns and overall prostate cancer risk after adjusting for multiple tests, except for six specific phosphatidylcholines linked to advanced cases diagnosed within 10 years.
  • * Two metabolite patterns (1 and 2) showed inverse associations with advanced prostate cancer, while pattern 3 was related to prostate cancer death, indicating that metabolite profiles may change several years before advanced disease is detected.
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Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study.

Br J Cancer

November 2024

Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Article Synopsis
  • Inflammation plays a significant role in breast cancer progression and prognosis, particularly through pre-diagnostic plasma biomarkers in women.
  • A study involving 1,538 women showed that elevated levels of the inflammatory marker IL-6 were linked to increased risks of all-cause and breast cancer-specific mortality, especially in postmenopausal women.
  • Higher levels of IL-10 and TNFα were also associated with all-cause mortality, and an inflammatory score could indicate poorer long-term survival, particularly in postmenopausal breast cancer survivors.
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: Previous studies have shown that meal timing, poor sleep quality, and chronotype may play a relevant role in the development of type 2 diabetes mellitus (T2DM). However, its relationship with macronutrients by eating occasions has not been explored deeply. : Our aim was to estimate the association between chrono-nutrition, sleep quality, chronotype, and the prevalence of T2DM.

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Article Synopsis
  • * A study conducted on 27 P. nobilis individuals from both natural populations and captivity revealed differences in their immune competence, showing that hemolymph from captive animals had a significantly lower Total Hemocyte Count (THC) compared to those from the wild.
  • * Flow cytometry and ultrastructure analysis indicated that captive pen shells exhibited impaired phagocytosis abilities against pathogens, likely caused by PnPV infection disrupting the hemocyte cyt
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Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study.

BMC Med

June 2024

Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), 25 Avenue Tony Garnier, Lyon, 69007, France.

Article Synopsis
  • Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are linked to higher overall and cause-specific mortality risks, particularly cancer and cardiovascular disease (CVD).
  • A study involving 15,784 participants found that a higher Fatty Liver Index (FLI), indicating more severe liver fat accumulation, correlated with increased mortality rates, especially for CVD.
  • Individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic syndrome show heightened mortality risks, suggesting the need for greater awareness and management of these conditions.
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Objective: The objective of this study is to conduct a systematic review regarding the relationship between positive psychological factors, such as psychological well-being and pleasant emotions, and sports performance.

Method: This study, carried out through a systematic review using PRISMA guidelines considering the Web of Science, PsycINFO, PubMed and SPORT Discus databases, seeks to highlight the relationship between other more 'positive' factors, such as well-being, positive emotions and sports performance.

Settings: The keywords will be decided by a Delphi Method in two rounds with sport psychology experts.

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Background: HIV-1-associated neurocognitive disorders (HAND) in stable patients undergoing antiretroviral therapy (ART) may result from ongoing immune dysregulation and chronic inflammation. A contributing factor may result from the unstable HLA class I allele, HLA-C*07.

Objective: To assess the genetic profile of killer-cell immunoglobulin-like receptors (KIR), human leukocyte antigens (HLA), and immune activation or senescence markers and their association with HAND in stable HIV-1 patients receiving ART.

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Article Synopsis
  • Enterovirus D68 (EV-D68) infections can cause severe respiratory issues and acute flaccid myelitis, with a significant rise reported during the fall-winter season of 2021-2022 across Europe.
  • The study by the European Non-Polio Enterovirus Network (ENPEN) analyzed over 10,481 samples from 19 countries, identifying 1,004 as EV-D68, predominantly affecting young children, where 37.9% required hospitalization.
  • Additionally, genetic analyses uncovered two new B3-derived lineages without regional patterns, indicating a notable impact of the infections and the emergence of new virus strains.
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Nitrosyl-heme and Heme Iron Intake from Processed Meats and Risk of Colorectal Cancer in the EPIC-Spain Cohort.

Cancer Epidemiol Biomarkers Prev

June 2024

Unit of Nutrition and Cancer, Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The International Agency for Research on Cancer classified processed meats (PM) as "carcinogenic" and red meat as "probably carcinogenic" for humans. The possible relationship between colorectal cancer risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds.

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Background: The consumption of processed meats (PMs) and red meats are linked to the likelihood of developing colorectal cancer. Various theories have been proposed to explain this connection, focusing on nitrosyl-heme and heme iron intake. We hypothesized that differences in nitrosyl-heme and heme iron intakes will be associated with various sociodemographic and lifestyle factors.

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Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC).

EBioMedicine

March 2024

International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, 69007, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Article Synopsis
  • - The study investigates the relationship between specific lipid metabolites and colorectal cancer risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), comparing 1,591 colorectal cancer cases with matched controls.
  • - Out of 97 lipid metabolites analyzed, 24 showed an inverse association with colon cancer risk, notably hydroxysphingomyelin (SM (OH)) C22:2 and acylakyl-phosphatidylcholine (PC ae) C34:3, which remained significant even after adjustments.
  • - The findings suggest that higher pre-diagnostic levels of certain lipids may be linked to a lower risk of developing colorectal cancer, warranting further research to confirm these associations.
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Background: Artificial intelligence (AI) is becoming more useful as a decision-making and outcomes predictor tool. We have developed AI models to predict surgical complexity and the postoperative course in laparoscopic liver surgery for segments 7 and 8.

Methods: We included patients with lesions located in segments 7 and 8 operated by minimally invasive liver surgery from an international multi-institutional database.

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In 2019, ACWY meningococcal vaccination for people born between 2001 and 2007 was recommended. In Murcia, during the first 9 months, the coverage was 52.89%.

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Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort.

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Article Synopsis
  • There has been significant mass mortality of noble pen shell in various Mediterranean regions over the past seven years linked to a picornavirus that affects immune cells.
  • A study analyzed specimens from Spain and Italy using electron microscopy and sequencing to identify the virus and understand its impact on the immune cells.
  • Results showed the virus's presence in 100% of the samples, leading to lower total hemocyte counts and indicating severe immune dysfunction and viral replication in affected animals.
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The etiology of prostate cancer is not fully elucidated. Among environmental risk factors, endocrine-disrupting chemicals (EDCs) deserve special mention, as they alter metabolic pathways involved in hormone-dependent cancers. Epidemiological evidence assessing the carcinogenicity of EDCs is scarce.

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Background: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited.

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Breast cancer risk for the joint exposure to metals and metalloids in women: Results from the EPIC-Spain cohort.

Sci Total Environ

February 2024

Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Legal Medicine and Toxicology, University of Granada, 18016 Granada, Spain.

Environmental factors play a role in breast cancer development. While metals and metalloids (MMs) include some carcinogens, their association with breast cancer depends on the element studied. Most studies focus on individual MMs, but the combined effects of metal mixtures remain unclear.

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Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies.

BMC Med

November 2023

Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), 25 Avenue Tony Garnier, CS 90627, 69366, Lyon, CEDEX 07, France.

Background: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.

Methods: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment.

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