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Collagenous colitis appeared after 6-year administration of lansoprazole.

Clin J Gastroenterol

February 2010

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.

Collagenous colitis (CC) is one of the causes of undefined watery diarrhea, which is histologically accompanied by thickening of the subepithelial collagen layer. CC associated with lansoprazole normally occurs within several weeks after initial administration, but no case presenting after long-term administration of lansoprazole has yet been reported. A 77-year-old male with 6-year history of administration of lansoprazole complained of watery diarrhea and weight loss.

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