1,112 results match your criteria: "Multiple Sclerosis Spine"
De-escalating and discontinuing disease-modifying therapies in multiple sclerosis.
Brain
December 2024
Department of Neurology, Multiple sclerosis center, Pitié-Salpêtrière Hospital, AP-HP, 47 bd de l'Hôpital, 75013 Paris, France.
The development of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS) has been highly successful in recent decades. It is now widely accepted that early initiation of DMTs after disease onset is associated with a better long-term prognosis. However, the question of when and how to de-escalate or discontinue DMTs remains open and critical.
View Article and Find Full Text PDFBeyond the Stroke: A Case Report of Multiple Sclerosis.
Cureus
November 2024
Department of Anaesthetics and Intensive Treatment Unit (ITU), Birmingham Heartlands Hospital, Birmingham, GBR.
Multiple sclerosis is an inflammatory, autoimmune demyelinating condition and poses diagnostic challenges due to varied presentations. This case report presents a divergence from typical clinical presentations of multiple sclerosis (MS), as the initial presentation resembled symptoms of a brain stem stroke. Conventionally, MS suspicion arises in the presence of previous neurological deficits or signs of optic neuritis.
View Article and Find Full Text PDFAssociation of the Cervical Canal Area With Disability and Progression in People With Multiple Sclerosis.
Neurology
January 2025
From the Multiple Sclerosis Centre of Catalonia (Cemcat) & Neurology Department (N.M.-O., P.C.-M., N.B., A.V.-J., M.T., X.M., J.S.-G.), and Section of Neuroradiology (D.P., M.A., C.A., À.R.), Department of Radiology (IDI), Vall Hebron University Hospital, Barcelona; Neuroimaging Research Unit (P.V., M.M., A.M., P.P., M.A.R., M.F.), Division of Neuroscience, Neurology Unit, and Neurorehabilitation Unit (M.M., M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Multiple Sclerosis Center (MSC) (C.G., C.Z.), Department of Neurology, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale; Faculty of Biomedical Sciences (C.G., C.Z.), Università della Svizzera Italiana (USI), Lugano, Switzerland; Faculty of Brain Sciences (F.B.), University College London Queen Square Institute of Neurology, University College London; National Institute for Health Research (F.B.), University College London Hospitals Biomedical Research Centre, United Kingdom; MS Center Amsterdam (F.B., M.M.S., E.M.M.S.), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Clinic of Neurology (A. Gallo, A.B.), and MRI Research Center SUN-FISM (A. Gallo, A.B.), Second University of Naples, Italy; Queen Square MS Centre (O.C., F.D.A., M.C.Y.), Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (O.C., F.D.A.), Biomedical Research Centre, University College London Hospitals; Nuffield Department of Clinical Neurosciences (J.P., L.M.), Oxford, United Kingdom; Department of Neurology (A. Gass, P.E.), Mannheim Center of Translational Neurosciences (MCTN), Medical Faculty Mannheim, Heidelberg University; Institute of Neuroradiology (C.L., B.B.), St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Vita-Salute San Raffaele University (P.P., M.A.R., M.F.); Neurology Unit (P.P., M.A.R., M.F.), and Neuropshysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background And Objectives: In multiple sclerosis (MS), brain reserve serves as a protective factor against cognitive impairment. Previous research has suggested a structural counterpart in the spine-spinal cord reserve-seemed to be associated with physical disability. This study aimed to investigate the potential of the cervical canal area (CCaA) as a proxy for spinal cord reserve in a multicentric cohort of people with MS (PwMS).
View Article and Find Full Text PDFStrength training attenuates neuropathic pain by Preventing dendritic Spine dysgenesis through Suppressing Rac1 and inflammation in experimental autoimmune encephalomyelitis.
Mult Scler Relat Disord
November 2024
Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
Article Synopsis
- Chronic pain is a significant issue for multiple sclerosis (MS) patients, greatly affecting their quality of life, and Rac1 plays a crucial role in the associated neuropathic pain.
- A study showed that a 4-week strength training program reduced harmful markers (like Rac1, IL-1β, TNF-α, and MDA) in the spinal cord while improving beneficial ones (TGF-β1 and SOD activity).
- The results indicated that regular physical exercise can alleviate neuropathic pain and enhance motor function in MS by tackling inflammation and oxidative stress in the spinal cord.
Improved MR Detection of Optic Nerve Demyelination With MP2RAGE-FLAWS Compared With T2-Weighted Fat-Saturated Sequences.
Invest Radiol
November 2024
From the Department of Neuroradiology, AP-HP, Henri Mondor University Hospital, Créteil, France (R.A., T.E., I.M., B.B.); University Paris Est Créteil, INSERM, IMRB, Créteil, France (N.O.); Department of Public Health, AP-HP, Henri Mondor University Hospital, Créteil, France (N.O.); EA 4391, Université Paris Est Créteil, Créteil, France (A.C., B.B.); Department of Neurology, AP-HP, Henri Mondor University Hospital, Créteil, France (A.C.); Department of Neuroradiology, A. Rothschild Foundation Hospital, Paris, France (A.L.); Paris Cité University, Paris, France (A.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.K.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.K.); Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.K.); and Siemens Healthcare SAS, Courbevoie, France (A.M.).
Objectives: Nonenhanced T1-w sequences such as magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) and derived fluid and white matter suppression (FLAWS) have demonstrated high performance for detecting brain parenchymal and cervical spine demyelinating lesions in multiple sclerosis. However, their potential for identifying optic nerve (ON) demyelination remains unexplored. The aim of this study was to evaluate the performance of compressed sensing-accelerated (CS) MP2RAGE-FLAWS imaging for detection of ON demyelination lesions compared with T2-w fat-saturated (FS) TSE imaging in a clinical setting.
View Article and Find Full Text PDFAdult Onset Acute Disseminated Encephalomyelitis: A Case Report.
Cureus
October 2024
Internal Medicine, Centro Hospitalar Universitário Cova da Beira, Covilhã, PRT.
Article Synopsis
[Classic presentation of neuromyelitis optica: clinical case and review of the literature].
Rev Med Inst Mex Seguro Soc
September 2024
Hospital Star Médica, Área de Urgencias. San Luis Potosí, San Luis Potosí, México.
Background: Neuromyelitis optica (NMO or Devic's syndrome), characterized by acute attacks of optic neuritis and transverse myelitis, is associated with antiaquaporin 4 antibodies (anti-NMO-IgG) and it has a higher prevalence in non-Caucasian populations, where multiple sclerosis is less common.
Clinical Case: 41-year-old man, with no significant personal medical history, presented with clinical symptoms including paresthesias in the right hemibody and homonymous hemianopsia in the left eye. Three weeks later, he developed lumbalgia associated with paresthesias in both lower limbs up to the T7 sensory level, as well as acute urinary retention, followed by paraplegia.
Factors associated with low health-related quality of life in persons with multiple sclerosis: A quantile-based segmentation approach.
PLoS One
November 2024
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Article Synopsis
Introduction: Real-world studies in the USA report that 41-56% of patients with multiple sclerosis (MS) are ≥ 50 years old, yet data on their response to disease-modifying therapies (DMTs) is limited. Dimethyl fumarate (DMF) is an oral DMT approved for treating relapsing MS. This analysis evaluated the safety, efficacy, and immunophenotype changes of DMF in patients ≥ 50 years compared with patients < 50 years.
View Article and Find Full Text PDFRising Prevalence of Multiple Sclerosis in Switzerland: Results from the Swiss Multiple Sclerosis Registry.
Neuroepidemiology
November 2024
Department of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Introduction: Understanding the prevalence of multiple sclerosis (MS) provides information for healthcare planning and helps identify trends and patterns of disease occurrence. For Switzerland, the number of persons with MS (pwMS) was last estimated at approximately 15,000 in 2016. The study's objectives were to update estimates of MS prevalence and characterise the change in MS prevalence in Switzerland between 2016 and 2021, the last year with complete administrative data.
View Article and Find Full Text PDFFirst case of progressive solitary sclerosis with relapsing attacks: A 49-year-old woman.
Clin Case Rep
November 2024
Multiple Sclerosis Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran Iran.
Article Synopsis
- * The patient, a 49-year-old woman, experienced several relapses of right-sided weakness, responding initially well to treatment but later facing some residual symptoms and worsening condition.
- * Despite normal MRI results and comprehensive laboratory testing, the diagnosis of relapsing solitary sclerosis was confirmed, leading to treatment with rituximab to manage her condition.
Self-reports by persons with multiple sclerosis are an adequate surrogate for healthcare provider data on disease-modifying therapy and multiple sclerosis type.
Mult Scler Relat Disord
October 2023
Epidemiology, Biostatistics and Prevention Institute, University of Zurich (UZH), Zurich, Switzerland; Institute for Implementation Science in Health Care, University of Zurich (UZH), Zurich, Switzerland. Electronic address:
Article Synopsis
Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women- a case-control study.
Rheumatology (Oxford)
October 2024
Department of Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Lund University, Sweden.
Article Synopsis
- The study aimed to compare bone mineral density (BMD) and osteoporosis rates in systemic sclerosis (SSc) patients to those in a general population, highlighting specific SSc-related factors influencing BMD.
- It involved 211 SSc patients (majority women) and 505 control participants, measuring BMD at the hip and lumbar spine using X-ray technology, with specific criteria for osteopenia and osteoporosis.
- Results showed significantly lower BMD in SSc patients, particularly women, with factors like age, BMI, menopause, and certain SSc symptoms (like finger ulcers) contributing to decreased BMD, highlighting the need for bone health evaluations in all SSc patients.
Prevalence of presumed endplate junction failure at the lumbosacral intervertebral junction in dogs on computed tomography.
Vet Radiol Ultrasound
September 2024
Division of Diagnostic Imaging, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Article Synopsis
- * A retrospective CT scan study on 324 dogs found that 21% had presumed EPJF and another 21% had annulus fibrosus rupture (AFF), which were often located at the last lumbar vertebra’s caudal endplate.
- * The study indicates that EPJF is linked to more severe IVDH grades and factors like age and certain spinal conditions, suggesting a need for further research to clarify its clinical significance and relationship to other spinal issues.
Evaluation relationship between VDR gene and clinical and inflammatory factors in patients with RRMS.
Eur J Transl Myol
October 2024
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran.
Article Synopsis
- The study investigates the link between vitamin D receptor (VDR) gene changes and clinical factors in relapsing-remitting multiple sclerosis (RRMS) patients, as well as their association with obesity and other adipocyte-related factors.
- It finds that the FokI polymorphism in the VDR gene greatly increases the risk of developing RRMS, especially for individuals with the FF genotype, compared to healthy individuals.
- However, it concludes that none of the other examined polymorphisms show significant risk differences between obese patients and healthy controls, suggesting the need for more extensive research to validate these findings.
Fueling Recovery: The Therapeutic Role of Ketogenic Diet in Neurological Pathologies.
Cureus
September 2024
General Surgery, Shaikh Zayed Medical Complex, Lahore, PAK.
The ketogenic diet (KD) has gained a lot of attraction in the management of neurological disorders. KD therapies are high-fat, low-carbohydrate diets intended to shift energy consumption and metabolism from carbohydrates to fat in ketogenesis. The oxidative phosphorylation of ketone bodies generates energy packets for body cells, especially the central nervous system, replacing the role of glucose.
View Article and Find Full Text PDFIntegrated Rehabilitation of Longitudinal Extensive Transverse Myelitis: Study of a Complex Case.
Cureus
September 2024
Department of Neuro Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Longitudinal extensive transverse myelitis (LETM) is a rare neurological condition characterized by inflammation in the spinal cord affecting three or more vertebrae, leading to severe symptoms like weakness and sensory issues.
- LETM can be either idiopathic or linked to autoimmune diseases such as Multiple Sclerosis and Neuromyelitis Optica, and its diagnosis involves MRI imaging of the spine.
- A case study of a 62-year-old male showed improvements in mobility and functional independence after a combination of corticosteroids, IVIG, plasma exchange, and physical therapy following his diagnosis of LETM.
Evaluating the impact of multiple sclerosis on 2 year postoperative outcomes following long fusion for adult spinal deformity: a propensity score-matched analysis.
Spine Deform
September 2024
Department of Orthopaedic Surgery and Rehabilitation Medicine, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY, USA.
Article Synopsis
Preliminary findings of a 'test bundle' to accelerate the diagnosis of MS and NMOSD following optic neuritis.
Mult Scler Relat Disord
November 2024
Department of Neurology, University of Kentucky Medical Center, 740 S Limestone, Lexington, KY 40536, United States.
No study has investigated the length of time it takes to diagnose multiple sclerosis (MS) or neuromyelitis optic spectrum disorder (NMOSD, aquaporin 4 antibody disease or myelin oligodendrocyte glycoprotein antibody disease, MOGAD) following the onset of de novo optic neuritis (ON). Minimizing the time between ON and downstream diagnoses needs urgency since early diagnosis equals early treatment. The time elapsed from ON to a subsequent diagnosis of MS/NMOSD was estimated through analysis of retrospective data collected from the Axon Registry (AR) of the American Academy of Neurology (AAN) and from the University of Kentucky (UK), Lexington.
View Article and Find Full Text PDFSafety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials.
Lancet Neurol
November 2024
Ares Trading, an affiliate of Merck KGaA, Eysins, Switzerland.
Article Synopsis
- Evobrutinib, a BTK inhibitor, was evaluated for safety and efficacy against teriflunomide in treating relapsing multiple sclerosis in two phase 3 trials involving nearly 2,300 participants across 52 countries.
- Participants aged 18-55 with specific disability scores were randomly assigned to receive either evobrutinib or teriflunomide, with both studies designed as double-blind to avoid bias among participants and researchers.
- The primary endpoint was the annualized relapse rate over 156 weeks, with data collected from June 2020 to October 2023, showing that 66-67% of the participants were female across the trials.
Article Synopsis
- Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
- In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
- There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids.
Gut Microbes
September 2024
The MOE Key Laboratory for Standardization of Chinese Medicines and the MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Article Synopsis
Cementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations.
JBJS Essent Surg Tech
September 2024
Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland.
Article Synopsis
- Total knee arthroplasty (TKA) is a common surgical procedure for patients with severe knee osteoarthritis, especially when non-surgical treatments fail, leading to significant improvements in pain, function, and quality of life.
- The procedure can use various components (cemented, cementless, or a hybrid) and is generally performed with a focus on mechanical alignment, although newer alignment strategies like gap and kinematic balancing are showing promising results in early studies.
- The preferred surgical technique for cementless TKA involves a specific patient positioning and incision approach, starting with the application of a thigh tourniquet and a parapatellar incision, ensuring proper alignment and access during the surgery.*
Cerebrospinal fluid soluble CD27 is a sensitive biomarker of inflammation in autoimmune encephalitis.
J Neurol Sci
November 2024
Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark. Electronic address:
Article Synopsis
Traumatic spinal cord injury and its correlation to risk of autoimmune/-inflammatory disease.
Spinal Cord
November 2024
Cense Spine, Department of Neurosurgery, Aarhus University Hospital, Aarhus N, Denmark.