1 results match your criteria: "Multidisciplinary Institute of Cell Biology (Argentine Research Council and Scientific Research Commission[Affiliation]"
Endocrinology
July 2015
Departamento de Genética del Desarrollo y Fisiología Molecular (I.L., R.M.U., L.J.-H., P.J.-B., J.-L.C.), Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, México; Laboratory of Neurophysiology (A.C., M.P.), Multidisciplinary Institute of Cell Biology (Argentine Research Council and Scientific Research Commission, Province of Buenos Aires), La Plata, Buenos Aires 1900, Argentina; and Dirección de Investigaciones en Neurociencias (E.S.-J.), Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México D.F. 14370, México.
Fasting down-regulates the hypothalamus-pituitary-thyroid (HPT) axis activity through a reduction of TRH synthesis in neurons of the parvocellular paraventricular nucleus of the hypothalamus (PVN). These TRH neurons project to the median eminence (ME), where TRH terminals are close to the cytoplasmic extensions of β2 tanycytes. Tanycytes express pyroglutamyl peptidase II (PPII), the TRH-degrading ectoenzyme that controls the amount of TRH that reaches the anterior pituitary.
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