PREVALENCE AND DETERMINANTS OF DEPRESSION AMONG AMPUTEES IN QUETTA REGION.

Background: Depression is increasingly diagnosed in the general population today. The loss of a limb through amputation, which can result in disfigurement, may also contribute to the development of depression despite pre-operative counselling. Understanding the factors associated with depression in individuals with limb amputation is important to effectively identify and manage this psychological condition.

CORRELATION BETWEEN FACIOLINGUAL INCLINATION OF MAXILLARY CENTRAL INCISORS AND MOLARS WITH MAXILLARY AND MANDIBULAR MORPHOLOGY.

Background: The torque of maxillary incisors and molars forms an important component of smile esthetics. The inclination of these teeth may be affected by maxillary and mandibular dimensions. The study aimed to evaluate the correlation between the faciolingual inclinations of maxillary incisors and first molars with palatal width (PW), palatal depth (PD), maxillomandibular angle (MMA) and mandibular width (MW) using cone beam computed tomography scans.

Evaluating Risk Factors and the Burden of Silent Myocardial Ischemia Among Diabetic Patients.

Introduction: Silent myocardial ischemia (SMI) is a significant concern for diabetic patients, often remaining undetected until severe complications arise. Prolonged hyperglycemia, poor glycemic control, and lifestyle factors contribute to its risk, with older adults and those with long-standing diabetes particularly vulnerable.

Objective: To assess the prevalence and predictors of SMI in adults with diabetes, emphasizing long-term management and monitoring.

The role of surface modification in the interactions between CdTe quantum dots and ABC transporters in lung cancer cells.

This paper aimed to investigate the role of surface modification on the potential interaction between CdTe quantum dots (QDs) and ABC transporters in doxorubicin-resistant lung cancer (A549/DOX) cells. For this purpose, CdTe QDs modified with -glutathione (GSH), -carboxy (COOH), and -amino (NH) were applied, with the former two QDs exhibiting negative potentials and the latter ones being positive. All the three QDs reduced cell viability in a concentration-dependent manner, with NH-CdTe QDs being more toxic.

Understanding childhood obesity in Pakistan: exploring the knowledge, attitudes, practices of mothers, and influential factors. A cross-sectional study.

Background: Childhood obesity is a significant public health issue with far-reaching implications. The World Health Organization reported that in 2020, around 38 million children under five were overweight or obese globally, and in 2016, 340 million children and adolescents aged 5-19 were affected. In Pakistan, the situation is alarming; 66.

Clinical pharmacist-led antifungal drug utilization reviews in cancer care hospital: a prospective audit and feedback.

Background And Objective: The global rise in systemic fungal infections and increased antifungal use underscores the need for pharmacist-led antifungal stewardship in oncology but data on such interventions are scarce. This study aimed to evaluate the clinical pharmacist-led antifungal drug utilization reviews for optimizing antifungal therapy in a specialized cancer care hospital.

Patients And Method: This pharmacist-led prospective audit and feedback study evaluated 350 admitted patients with cancer who were prescribed systemic antifungals.

Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach.

a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits.

The protective roles of Oryza glumaepatula and phytohormone in enhancing rice tolerance to cadmium stress by regulating gene expression, morphological, physiological, and antioxidant defense system.

The heavy metal cadmium (Cd) is highly poisonous and has received significant attention from environmental scientists due to its harmful impacts on plants. Oryza glumaepatula is a wild rice that contains useful genes against biotic and abiotic stresses. Therefore, the current study used SG007, a single-segment substitution line (SSSL), generated by crossing O.

Evaluating the Effectiveness of Neuroprotective Strategies in Enhancing Post-stroke Recovery: A Systematic Review of Meta-Analyses and Clinical Trials.

This systematic review evaluates the effectiveness of various neuroprotective strategies in enhancing recovery following acute ischemic stroke, focusing on interventions such as normobaric oxygen (NBO), lithium, selective serotonin reuptake inhibitors (SSRIs), and Cerebrolysin. Drawing upon data from six primary studies, including randomized controlled trials (RCTs) and meta-analyses, we assessed these therapies' impact on functional outcomes, motor recovery, and neurological improvement. Normobaric oxygen, across 12 RCTs, demonstrated limited efficacy in improving recovery outcomes or reducing mortality.

Long-Term Efficacy and Safety of Adhesion Prevention Agents in Abdominal and Pelvic Surgeries: A Systematic Review.

This systematic review evaluates the long-term efficacy and safety of adhesion prevention agents in abdominal and pelvic surgeries, synthesizing data from randomized controlled trials and meta-analyses. Adhesions, common postoperative complications, can lead to significant morbidity, including chronic pain, infertility, and bowel obstruction. Various agents, including hyaluronic acid-carboxymethylcellulose films and icodextrin solutions, have been developed to mitigate these risks.

Cultural Competency in Dental Practice: Navigating the Experiences and Perspectives of Dentists in South Punjab, Pakistan.

Introduction Cultural competence in healthcare embraces the principles of equal access and nondiscriminatory services in healthcare delivery. Dentists as significant healthcare professionals should definitely have the skills needed to diagnose and treat patients' conditions, but it is crucial to also address nontechnical skills such as cross-cultural communication, the ability to empathize, and inclusive-mindedness. Globally, cultural competency training has been included in healthcare educational programs; however, national practices reportedly have revolved around patients' clinical competencies and thus entailed overlooking the cultural dimensions of dental education that include diverse sociocultural factors that influence how dental practices are taught, learned, and delivered.

Pulmonary metastasis of giant cell tumour of tibia.

Giant cell tumour of the tibia with pulmonary metastasis is very rare and the malignancy usually appears several years after the initial lesion. Imaging at the earliest instance is highly beneficial since surgical resection to remove the metastases raises survival rates; therefore, relentless follow-up in GCT is vital.

Spirulina Unleashed: A Pancreatic Symphony to Restore Glycemic Balance and Improve Hyperlipidemia and Antioxidant Properties by Transcriptional Modulation of Genes in a Rat Model.

Hyperlipidemia is the root cause of numerous chronic conditions, leading to high mortality rates around the globe. Spirulina () microalgae serve as a promising reservoir of bioactive compounds with diverse pharmacological properties. The current study examined the nutritional profile of spirulina powder in relation to strict glycemic control, specifically focusing on its potential to lower lipid levels.

Rice and heavy metals: A review of cadmium impact and potential remediation techniques.

In recent decades, the menace of heavy metals to food security and human health has become a serious concern. Given its status as the primary provider of food globally, significant research has been done to ensure the safe cultivation of rice, particularly concerning the mitigation of heavy metal contamination. Therefore, this article focuses on the effects and poisoning mechanism of heavy metals, primarily cadmium, on rice.

Biochemical investigation of FOXP3 genetic polymorphism and its association with biochemical parameters in pre-eclampsia patients.

This study addresses the pivotal question of the association between FOXP3 gene polymorphism and pre-eclampsia (PE), employing the Tetra ARMS PCR method for analysis. PE, a multifaceted disorder marked by hypertension and organ dysfunction during pregnancy, led to an exploration of FOXP3 due to its integral role in immune regulation and its implication in various autoimmune and inflammatory disorders. The primary objective was to discern the relationship between FOXP3 gene polymorphism (rs2232365) and the risk of PE.

Inherited Spinocerebellar Ataxia Segregates with Intra-Familial Genetic Heterogeneity in a Consanguineous Pakistani Family: A Report of a Potential Novel Candidate Gene.

Hereditary spinocerebellar ataxia (SCA) is a group of genetic neurodegenerative disorders caused by a variety of gene variants. At least 44 types of SCAs have been identified to date, and more than 35 genes and hundreds of variants have been reported that are associated with SCAs. We have investigated a Pakistani consanguineous six-generation family with SCA by using whole-exome sequencing analysis.

Evaluation of wound healing activity of hydromethanolic extract of Jacobaea maritima leaves in rabbits.

The study investigated the wound healing efficacy of Jacobaea maritima leaf extract in rabbits through various wound models. A methanol-based extract was prepared from air-dried J. maritima leaves and used to formulate ointments at concentrations of 5%, 10% and 20%.