3,015 results match your criteria: "Muhimbili University of health and Allied Sciences[Affiliation]"
J Glob Antimicrob Resist
January 2025
Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Clinical Science, University of Bergen, Bergen, Norway. Electronic address:
Purpose: To understand the mechanisms of carbapenem-resistant Klebsiella pneumoniae (CRKP) from Tanzania and characterize the genomes carrying the carbapenemase genes.
Methods: Clinical CRKP isolates were selected from ongoing antimicrobial-resistant surveillance at Muhimbili National Hospital, Dar es Salaam, Tanzania. Whole-genome sequencing was performed utilizing Illumina and Nanopore platforms.
BMC Health Serv Res
January 2025
Department of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Background: Over the years, the processing of research proposals for ethical approvals have been done manually through a review of hard copies. Longer turn-around-time, increased financial costs to researchers and cumbersome submission processes are few of the challenges inherent to paper-based review of research proposals. This has necessitated the shift to electronic management of research proposals, Research Ethics Information Management Systems (REIMS).
View Article and Find Full Text PDFPLoS One
January 2025
School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Background: Adherence to HIV treatment regimens involves the consistent and correct intake of all prescribed medications. The implementation of antiretroviral therapy (ART) program has significantly reduced mortality among adolescents living with HIV. However, adherence to ART is lower among adolescents compared to other sub-populations and even lower in sub-Saharan Africa.
View Article and Find Full Text PDFAIDS Care
January 2025
Department of Internal Medicine, Center for Global Health, Weill Cornell Medical College, New York City, New York, USA.
Pediatric Health Med Ther
December 2024
Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.
Purpose: Tanzania is the fifth country with the highest sickle cell disease (SCD) prevalence globally. Although hydroxyurea (HU) is available, only 25% of persons with SCD are reported to use it in Tanzania. Perceived disease threat is associated with medication usage in patients with chronic diseases.
View Article and Find Full Text PDFBMC Public Health
December 2024
Muhimbili University of Health and Allied Sciences, Dar es salaam, United Republic of Tanzania.
Introduction: It is estimated that 1.3 billion people in the world have hypertension and a large proportion of them are unaware. Waist circumference has emerged as Potential predictor of Cardiovascular Diseases (CVD) risk; however, fewer studies in Tanzania have evaluated its role in screening for CVD risk.
View Article and Find Full Text PDFVaccine
December 2024
Access to Medicines Research Centre, Faculty of Economics and Business, KU Leuven, 3000 Leuven, Belgium.
Background: Immunization is pivotal for health-related sustainable development, necessitating resilient and sustainable immunization systems. This scoping review explores challenges and strategies for sustained vaccine uptake in the new Decade of Vaccines (2021-2030) within sub-Saharan Africa, encompassing routine and non-routine vaccines.
Methods: The review followed the Joanna Briggs Institute's methodology to examine English-language articles published from January 01, 2021, to May 29, 2023.
Front Immunol
December 2024
Division of Infectious Diseases, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Introduction: Malaria remains a significant burden, and a fully protective vaccine against is critical for reducing morbidity and mortality. Antibody responses against the blood-stage antigen Merozoite Surface Protein 2 (MSP2) are associated with protection from malaria, but its extensive polymorphism is a barrier to its development as a vaccine candidate. New tools, such as long-read sequencing and accurate protein structure modelling allow us to study the genetic diversity and immune responses towards antigens from clinical isolates with unprecedented detail.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Background: Prostate cancer is a common cancer among men globally and its treatment affects quality of life. Poor patients' perception of prostate cancer services may lead to their late presentation for care, often presenting with the advanced stage of the disease. This may vary from one region to another.
View Article and Find Full Text PDFBMC Res Notes
December 2024
Department of Otorhinolaryngology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Objective: Few studies characterizing clinical outcomes of head and neck cancer (HNC) patients in sub-Saharan Africa report the proportion of patients who initiate and complete treatment, information integral to contextualizing survival outcomes. This retrospective cohort study describes HNC patients who presented to Muhimbili National Hospital and Ocean Road Cancer Institute in 2018, the highest-volume oncology tertiary referral centers in Tanzania. Logistic regression was applied to assess predictors of treatment initiation and completion.
View Article and Find Full Text PDFSleep
December 2024
School of Health and Society, University of Wollongong, Australia.
Study Objectives: To examine 1) multidimensional sleep profiles in pre-schoolers (3-6 years) across geocultural regions and 2) differences in sleep characteristics and family practices between Majority World regions (Pacific Islands, Sub-Saharan Africa, Eastern Europe, Northeast Asia, Southeast Asia, South Asia, the Middle East and North Africa, Latin America) and the Minority World (the Western world).
Methods: Participants were 3507 pre-schoolers from 37 countries. Nighttime sleep characteristics and nap duration (accelerometer: n=1950) and family practices (parental questionnaire) were measured.
Intensive Care Med
December 2024
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Purpose: To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings.
Methods: An international multidisciplinary Steering Committee with expertise in sepsis management and including a Delphi methodologist was convened by the Asia Pacific Sepsis Alliance (APSA). The committee selected an international panel of clinicians and researchers with expertise in sepsis management.
Pan Afr Med J
December 2024
Faculté de Médecine et d'Odontostomatologie, Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali.
Since its inception in 2003, the African Society of Human Genetics (AfSHG) has been central to the promotion of genetics research on the continent, and facilitated the networking of African researchers within Africa and abroad, thereby significantly contributing to the career development of African geneticists. The continuation of these accomplishments was stimulated by the 12 international conference of AfSHG held jointly with the 1 Congress of the Malian Society of Human Genetics (MSHG) in Bamako, Mali from September 18 to 21 2019. The main theme of the conference was "Human Genetics and Genomics as a Unifying Factor for Harmony and Progress in Africa".
View Article and Find Full Text PDFReprod Health
December 2024
Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Background: Tanzania, like most low- and middle-income countries, is facing an increasing prevalence of obesity in the general population, including among women of reproductive age. Excess weight pre-pregnancy is a risk factor for the onset of gestational diabetes mellitus (GDM), which is associated with several poor pregnancy outcomes. Screening for GDM, as a primary preventive measure, is not systematically done in Tanzania.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Thematic Studies: Environmental Change, Centre for Climate Science and Policy Research (CSPR), Linköping University, SE-58183, Linköping, Sweden.
Soils require the application of biochar to improve degradation. The objective of this study was to evaluate the long-term effects of a field experiment on soil organic matter (SOM), soil organic carbon (SOC), and soil moisture content in Karagwe, Tanzania. Seven years ago, a field experiment was conducted using a Latin rectangle design with four replications.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
December 2024
Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudia Arabia.
Background: Marburg virus disease (MVD) is categorized among viral hemorrhagic fevers. MVD is associated with high rates of morbidity and mortality. This study aimed to identify factors affecting MVD knowledge, attitudes and practices in sub-Saharan African countries.
View Article and Find Full Text PDFEpilepsia
December 2024
Global Health Institute, University of Antwerp, Antwerp, Belgium.
Objective: In onchocerciasis-endemic areas, limited access to antiseizure medications (ASMs) contributes to a high epilepsy burden. This study evaluated the impact of a community-based epilepsy care program in Mahenge, Tanzania, an onchocerciasis-endemic area with high epilepsy prevalence.
Methods: A baseline survey (2017-2018) identified persons with epilepsy (PWE) in four rural villages.
Trop Med Health
December 2024
Department of Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Malaria rapid diagnostic tests (RDTs) targeting the Plasmodium falciparum histidine-rich protein 2 (PfHRP2) are widely used to diagnose P. falciparum infection. However, reports of P.
View Article and Find Full Text PDFBackground: Undernutrition in children is predominantly linked to lack of a balanced diet resulting from inadequate nutrition intake. This form of malnutrition remains a leading cause of morbidity and mortality under-five children, especially prevalent in low-income countries. Understanding the specific factors contributing to undernutrition among this group, particularly those associated with caregivers, is vital yet insufficiently explored.
View Article and Find Full Text PDFBMC Nutr
December 2024
General Practice Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Background: Feeding practices during infancy have a significant impact on a child's cognitive development and long-term health outcomes. Dietary diversity guidelines from the WHO and UNICEF recommend a diverse range of foods for children aged below 24 months for their optimal growth and development. However, in sub-Saharan Africa (SSA), little is known about the extent to which dietary diversity behaviour in children aged 6 to 24 months aligns with the recommendations and the factors associated with the differentials in dietary behaviour.
View Article and Find Full Text PDFOncol Rev
December 2024
Department of Obstetrics and Gynecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Survivin belongs to the inhibitor of apoptosis protein (IAP) family and is encoded by the baculoviral inhibitor of apoptosis repeat-containing, or BIRC5, gene. It is preferentially expressed in cancers with functional complexity in cell signaling cascades such as extracellular signal-regulated kinases (ERK), mitogen-activated protein kinases (MAPK), heat shock protein-90 (HSP90), epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase (PI3K), signal transducer and activator of transcription (STAT), hypoxia-inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF), and others. Survivin plays a role in cell division and cell death, properties that have attracted a large body of research to decipher its therapeutic and prognostic significance in cancer.
View Article and Find Full Text PDFAnesth Analg
January 2025
Department of Anaesthesia, Kamenge University Hospital, Bujumbura, Burundi.
Background: By 2015, 4 East African countries (Kenya, Uganda, Rwanda, and Burundi) had identified a deficit in the number of anesthesiologists, with a mean density of 0.30 physician anesthesia providers (PAP) per 100,000 population, which was significantly lower than the World Federation of Societies of Anaesthesiologists (WFSA) recommended minimum of 5.0/100,000 population.
View Article and Find Full Text PDFPan Afr Med J
December 2024
Department of Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Introduction: diuretic therapy is among the cornerstones of the management of heart failure in children with acquired or congenital heart diseases (CHD). Electrolyte derangements have been reported by various studies to be among the most common side effects following diuretic therapy. Despite that, there is limited documentation on the magnitude of this problem in our setting.
View Article and Find Full Text PDFInt Health
December 2024
Department of Global Health Entrepreneurship, Division of Public Health, Institute of Science Tokyo (formerly, Tokyo Medical and Dental University), Tokyo, Japan.
Background: The rise of hypertension (HTN) and diabetes mellitus (DM) in Tanzania underscores the importance of self-care practices (SCP) for disease management. Despite the proven effectiveness of SCP, financial barriers in resource-limited rural areas hinder continuous care. Health insurance (HI) emerges as a critical solution to alleviate financial constraints and support SCP.
View Article and Find Full Text PDFmedRxiv
November 2024
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: High-grade resistance to sulfadoxine-pyrimethamine in East and Southern Africa has prompted numerous trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine.
Methods: We conducted individual participant data meta-analyses of randomised trials comparing IPTp with dihydroartemisinin-piperaquine to sulfadoxine-pyrimethamine on maternal, birth, and infant outcomes. We searched the WHO International Clinical Trials Registry Platform, ClinicalTrials.