PCR-based characterization of nasal and ocular surface flora and functional analysis of bacterial metabolic pathways in congenital nasolacrimal duct obstruction.

Purpose: To evaluate the role of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Serratia marcescens, and Moraxella catarrhalis in the nasal and ocular surface flora, along with their metabolic activities in children with unilateral congenital nasolacrimal duct obstruction (CNLDO).

Methods: Swabs were taken from the bilateral inferior meatus and ocular surface of 26 children with unilateral CNLDO before probing. Nasal and ocular surface swabs from non-operated eyes of children who underwent unilateral blepharoptosis or strabismus surgery formed the control group.

Exploring the GSTP1 inhibition potential of photosensitizer compounds for enhanced cancer treatment in photodynamic therapy.

Photodynamic therapy (PDT) has gained considerable attention in cancer treatment due to its non-invasive nature and the ability of photosensitizers to generate reactive oxygen species upon light activation, leading to tumor destruction. Glutathione S-transferase P1 (GSTP1) is a key enzyme in chemotherapy resistance, often overexpressed in various cancers, and its inhibition of GSTP1 presents a promising strategy to enhance cancer treatment. This study is aimed at assessing the potential of prominent photosensitizers as GSTP1 inhibitors through molecular docking analysis to strengthen the efficacy of PDT.

Relationship between serum levels of ANGPTL8, Apo C2, and human placental lactogen (hPL) in patients with gestational diabetes mellitus: Interaction of LPL regulators with hPL, a possible contributing factor to insulin resistance.

Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance during pregnancy. We aimed to investigate the potential effects of betatrophin and ApoC2 in GDM, focusing on their roles in LPL (lipoprotein lipase) regulation and their relationship with hPL to elucidate the possible impact of hPL on lipid metabolism and its potential contribution to the development of GDM.

Methods: Thirty pregnant women with normal glucose tolerance and 29 with gestational diabetes mellitus (diagnosed by 75g OGTT between 24 and 28 weeks) were included in the study.

The Effect of Reflexology Socks in the Management of Opioid-Induced Constipation: A Randomized Controlled Trial.

Background: Constipation is an important symptom that is common in patients using opioids and leads to major health problems among patients. Reflexology is one of the approaches utilized to manage constipation.

Objective: To examine the effect of reflexology socks on constipation in patients with opioid-induced constipation.

Reliability and Validity of the Turkish Version of Work-Related Questionnaire for Upper Extremity Disorders (WORQ-UP).

Background: The Work-Related Questionnaire for Upper Extremity Disorders (WORQ-UP) serves as a patient-reported outcome measure to identify work-related limitations in individuals with upper extremity musculoskeletal disorders. This study aims to adapt the WORQ-UP into Turkish and subsequently evaluate its validity and reliability.

Methods: The Turkish WORQ-UP, along with the previously validated Turkish Quick DASH, were administered to 136 patients.

Functional Brain Network Disruptions in Parkinson's Disease: Insights from Information Theory and Machine Learning.

This study investigates disruptions in functional brain networks in Parkinson's Disease (PD), using advanced modeling and machine learning. Functional networks were constructed using the Nonlinear Autoregressive Distributed Lag (NARDL) model, which captures nonlinear and asymmetric dependencies between regions of interest (ROIs). Key network metrics and information-theoretic measures were extracted to classify PD patients and healthy controls (HC), using deep learning models, with explainability methods employed to identify influential features.

Effect of Epidermos Barrier Cream on Postoperative Parotidectomy Incision Scar.

The modified Blair incision is commonly used for superficial and deep lobe lesions of the parotid gland. The most common complication of the parotidectomy procedure is the postoperative surgical scar. Epidermos barrier cream is a type of cream that helps in wound healing by covering the wound.

Downregulation of MGLL and microRNAs (miR-302b-5p, miR-190a-3p, miR-450a-2-3p) in non-small cell lung cancer: potential roles in pathogenesis.

Genes involved in lipid metabolism have been considered potential therapeutic targets in lung cancer because lipid metabolism is severely disrupted in this cancer. Monoglyceride lipase (MGLL) is a lipolytic enzyme that converts monoacylglycerides to fatty acids and glycerol. MicroRNAs (miRNA), one of the most important epigenetic regulators of gene expression, are also considered potential biomarkers in diagnosing, treating, and prognosis lung cancer.

Investigating the P53-dependent anti-cancer effect of ibutamoren in human cancer cell lines.

The MDM2-p53 pathway plays a pivotal role in regulating cell cycle and apoptosis, with its dysfunction contributing to approximately 50% of human malignancies. MDM2, an E3 ubiquitin ligase, targets the tumour suppressor p53 for degradation, thereby promoting uncontrolled cell growth in cancers. Inhibiting the MDM2-p53 interaction represents a promising therapeutic strategy for reactivating p53's tumour-suppressive functions.

Comparison of time perception in individuals between focal and generalized epilepsy.

Background: Numerous cognitive impairments have been documented in patients with epilepsy, particularly in relation to memory and executive functions. However, research on time perception is relatively limited and primarily focuses on temporal lobe epilepsy. The current study seeks to compare time perception performance between patients with focal epilepsy and those with generalized epilepsy.

The comparison of hand grip strength between healthy volunteers and individuals diagnosed with temporal lobe epilepsy.

Purpose: Hand grip strength (HGS) is crucial for the performance of daily activities and has been linked to various clinical parameters, including morbidity, mortality, and both physical and cognitive functions. While HGS has been shown to decline in numerous diseases, it has not been previously examined in patients diagnosed with temporal lobe epilepsy. This study aims to investigate the differences in hand grip strength between individuals with temporal lobe epilepsy and healthy volunteers.

The Effect of Music on Preoperative Fear and Anxiety in Patients Undergoing Thyroid Surgery: A Randomized Controlled Trial.

Purpose: This study aimed to investigate the impact of music on preoperative fear and anxiety in patients undergoing thyroid surgery.

Design: This was a randomized controlled prospective study.

Methods: This study was conducted at the general surgery clinic of a training and research hospital from April 10, 2021 to April 1, 2022.

The experience of parents of children with intellectual disabilities/autism who experienced the Kahramanmaraş earthquake in Türkiye.

In the Kahramanmaraş earthquake on February 6, 2023, which was described as the most severe earthquake on land worldwide and the disaster of century, the loss of life and material losses reached serious levels. In this study, it was aimed to examine the experiences of 21 individuals diagnosed with autism spectrum disorder and intellectual disabilities affected by the Kahramanmaraş earthquake by interviewing their families regarding this process. Fifteen parents of one/more children diagnosed with intellectual disability/autism spectrum disorder participated in this study, which was conducted with a phenomenological design, one of the qualitative research designs.

Adipocyte-derived fatty acid uptake induces obesity-related breast cancer progression: a review.

Obesity is a metabolic disorder that occurs when excess energy taken into the body is stored as fat. It is known that this metabolic imbalance affects the development of other diseases such as cancer, cardiovascular diseases, insulin resistance, and diabetes. The main cellular component of adipose tissue is adipocytes, and the environmental interactions of adipocytes are important to study the mechanism of disorder formation.

The Effect of Foot Reflexology and Knee Massage With Black Cumin Seed Oil on Knee Osteoarthritis Symptoms.

This study aimed to examine the effect of foot reflexology and knee massage with black cumin seed oil on pain and fatigue symptoms in elderly individuals with knee osteoarthritis and assess which of these 2 applications is more effective. Our randomized controlled trial was conducted with 150 participants. Study data were collected from participants over 65 years who received outpatient treatment in a university hospital's physical therapy and rehabilitation unit and were determined to have no perception problems based on the Mini-Mental Test.

Can leisure education effect on screen time and perceived leisure benefits for college students?

Background: Since children and adolescents usually spend their theoretical course time at schools, they experience many negative effects of inactivity and physical inactivity. They are disadvantaged in terms of facing many health and social problems due to lack of physical activity. This sedentary life increases their exposure to screens and the time they spend sitting.

Does physical performance demonstrate patient-reported outcomes after lumbar spine surgery?

Background: Due to time and setting constraints in clinical practice, performing a comprehensive assessment with both questionnaires and physical performance tests may not be possible. This study aimed to demonstrate the relationship between physical performance and patient-reported outcomes in patients after Lumbar Spine Surgery (LSS).

Methods: A cross-sectional study was conducted with 50 participants who were followed up at least six months after LSS.

Examination of the relationship between health promotion behavior and game addiction in adolescents.

Objectives: Adolescence is defined as the transition period from childhood to adulthood. The present study aimed to examine the relationship between health promotion behavior and game addiction in a sample of Turkish adolescents.

Methods: The sample consisted of 340 adolescents aged 10-14 years (50.

Efficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: A randomized control trial.

Objective: To evaluate the efficacy of topical chitosan powder in reducing postoperative vaginal bleeding following a loop electrosurgical excision procedure (LEEP).

Methods: In this randomized controlled trial, patients who underwent LEEP were randomly assigned (1:1) to the chitosan group, in which the wound area was sprayed with chitosan powder using a spray pump, or the control group. The primary outcome was the median quantity of vaginal blood lost in the early postoperative period (defined as within 6 h of the procedure).

Effect of transcranial direct current stimulation with cognitive training on executive functions in healthy older adults: a secondary analysis from the ACT trial.

Cognitive aging has become a public health concern as the mean age of the population is ever-increasing. It is a naturalistic and common process of degenerative and compensatory changes that may result in neurocognitive disorders. While heterogeneous, cognitive aging mostly affects executive functions that may be associated with functional losses during activities of daily living.

Effects of Different Packaging Types and Storage Periods on Physicochemical and Antioxidant Properties of Honeys.

Preserving the nutritional value of honey without compromising its properties until consumption is crucial. However, different types of honey may respond differently to packaging and storage conditions. This study aimed to assess the effects of different packaging materials (tin cans, light-colored glass jars, and dark-colored glass jars) and storage durations (initial, 6 months, and 12 months) on the physicochemical and antioxidant properties of pine, flower, and thyme honey.